Navigation Links
Small study shows association between medication and reduction in brain amyloid levels related to AD
Date:10/10/2011

CHICAGO -- Although it is a small study and more clinical trials are needed, treatment with the medication gantenerumab appeared to result in a reduction in brain amyloid levels in patients with Alzheimer disease, according to a report published Online First by Archives of Neurology, one of the JAMA/Archives journals.

"Genetic and neuropathological evidence suggests that the accumulation of amyloid-β (Aβ) peptides in the brain is a key event in the pathophysiology of Alzheimer disease (AD)," the authors provide as background information. They note that there are several therapeutic approaches currently being investigated to lower the levels of Aβ amyloid in the brain. "We previously reported the development of gantenerumab, a potent and fully human anti-Aβ antibody that binds specifically to Aβ plaques."

Susanne Ostrowitzki, M.D., from F. Hoffmann-La Roche Ltd., Neuroscience, Basel, Switzerland, and colleagues investigated whether treatment with gantenerumab leads to a measureable reduction in the level of Aβ amyloid in the brain and to try to figure out the mechanism of amyloid reduction. The study included patients with mild-to-moderate AD and was conducted at three university medical centers. Two consecutive groups of patients were randomized to receive two to seven infusions of intravenous gantenerumab (60 or 200 mg) or placebo every four weeks. Additionally, brain tissue from two patients who had AD (tissue obtained during tumor surgery) was coincubated with gantenerumab as an ex vivo study.

"Sixteen patients with end-of-treatment positron emission tomographic scans were included in the analysis," the authors report. "The mean [average] percent change from baseline difference relative to placebo (n = 4) in cortical brain amyloid level was -15.6 percent for the 60-mg group (n = 6) and -35.7 percent for the 200-mg group (n = 6)." The authors note that "Gantenerumab induced phagocytosis [a
'/>"/>

Contact: Luca Santarelli, M.D.
luca.santarelli@roche.com
JAMA and Archives Journals
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Genes Play Role in Prognosis With Non-Small Cell Lung Cancers
2. Certain genetic profiles associated with recurrence-free survival for non-small cell lung cancer
3. Small Increase in Diabetes Risk Noted in Statin Patients
4. Small to Mid-Sized Hospitals Turn to Orion Health to Implement Health IT Solutions for Improved Patient Care and Outcomes
5. Media, small businesses invited to ACS Webinar on ways to take advantage of Chinas dynamic growth
6. Small Time Company Rolls into the Big League: Trigger Point Performance Therapy Selected to Attend Athletes' Performance NFL Combine Preparation Program
7. Visual Cues that Improve Walking for People with Movement Disorders - Study Shows Small Change in Arrangement Can Make a Big Difference in Improvement Gained
8. Small Dogs Traced Back to Middle Eastern Wolf
9. Landrieu Comments on Presidents Small Business Health Care Report
10. Small molecule with high impact
11. A Small Grass-roots Non-profit, Announces That They Haven't Gone Away and are Still Alive with Helping the Disadvantaged Children in Ukraine
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/23/2015)... 23, 2015 Hastings and Hastings, a law ... a record number of legal representation client review requests for ... been a steady rise in the number of slip and ... home throughout the Valley. With that said, a large number ... by an experienced law firm. Hastings and Hastings is a ...
(Date:1/22/2015)... 23, 2015 The U.S. Pharmacopeial Convention ... Director of Clinical Pharmacy Services at North Carolina State’s ... of the 2015 Beal Award for Distinguished Volunteer Service—the ... relied on the contributions of volunteer experts to direct ...
(Date:1/22/2015)... (PRWEB) January 23, 2015 LunaDress, with its ... the fashion industry. Now, the business is showing its latest ... women’s dresses. , According to the company’s CEO, all the ... now offered with big discounts, up to 80% off. All ...
(Date:1/22/2015)... Woodloch Pines, an all-inclusive family resort located in ... number one best large hotel for families in the United ... annual Travelers’ Choice Awards. , TripAdvisor represents the world’s ... to millions of unbiased and honest traveler reviews. The best ...
(Date:1/22/2015)... January 22, 2015 Padre Murphy's and Owner ... of Pro Player Health Alliance (PPHA). The PPHA's ... in getting everyone, including NFL greats, treated for obstructive sleep ... leading groups supporting the cause in the valley. The most ...
Breaking Medicine News(10 mins):Health News:Hastings and Hastings Reports a Record Number of Client Review Requests for Slip and Fall Accidents in 2014 2Health News:Gigi Davidson, Pioneer in Veterinary Pharmacy and Leader in Pharmacy Compounding, honored with USP’s Beal Award for Dedication to Public Health 2Health News:Gigi Davidson, Pioneer in Veterinary Pharmacy and Leader in Pharmacy Compounding, honored with USP’s Beal Award for Dedication to Public Health 3Health News:Gigi Davidson, Pioneer in Veterinary Pharmacy and Leader in Pharmacy Compounding, honored with USP’s Beal Award for Dedication to Public Health 4Health News:LunaDress Shows The Latest Styles Of Wedding Dresses In 2015 2Health News:TripAdvisor Names Woodloch Pines Best Hotel for Families in America 2Health News:TripAdvisor Names Woodloch Pines Best Hotel for Families in America 3Health News:Padre Murphy's Holds NFL Retired Players Association Party Star Studded Event With Bud Light and Pro Player Health Alliance Sponsoring 2Health News:Padre Murphy's Holds NFL Retired Players Association Party Star Studded Event With Bud Light and Pro Player Health Alliance Sponsoring 3
... Stroke patients are more likely to die if they,re admitted ... regardless of the severity of the stroke, a new study ... patients admitted to 11 stroke centers in the province of ... the study. Seven days after a stroke, patients admitted ...
... Autism Consortium, an innovative Boston area collaboration of researchers, ... enhancing clinical care for autism spectrum disorders (ASDs), announced ... Medicine and Autism Therapeutics. The new focus was ... 26th, 2010, at Harvard Medical School in Boston. ...
... -- The plenary presentations at Neuroprosthetics 2010, an international ... limbs, will be available via a live webcast from ... Time) on Nov. 3, 2010. No registration is required ... and the full program for the symposium are available ...
... ROCHESTER, Minn. -- Statistics from the Centers for ... rank mortality related to chronic liver disease and ... death in adults in the U.S. Using a ... hepatitis, liver cancer ( http://www.mayoclinic.org/liver-cancer/ ) and obesity-related ...
... (November 1, 2010) According to a report published ... the American College of Surgeons , a grant-funded program ... young, underrepresented minority surgeons, is helping address shortages of ... The report states that the Diverse Surgeons Initiative (DSI) ...
... likely to have a recurrence of uterine cancer despite ... radiation therapy, according to researchers at Henry Ford Hospital ... study had similar surgeries and radiation therapy as the ... certainly wasn,t a factor in race being identified as ...
Cached Medicine News:Health News:Weekend Admissions Worse for Stroke Victims: Study 2Health News:Autism Consortium 2010 Symposium: New therapeutics focus, family resource guide announced 2Health News:Autism Consortium 2010 Symposium: New therapeutics focus, family resource guide announced 3Health News:Autism Consortium 2010 Symposium: New therapeutics focus, family resource guide announced 4Health News:Neuroprosthetics symposium to be webcast live from Worcester Polytechnic Institute Nov. 3 2Health News:Mayo researchers find mortality rates from liver diseases underestimated 2Health News:Diverse surgeons initiative effectively increases underrepresented minorities in academic surgery 2Health News:Race may influence uterine cancer recurrence, despite treatment 2
(Date:1/23/2015)... Markets ( http://www.researchandmarkets.com/research/5dh22x/urinary_catheters ) has announced the ... Foley Catheters, Intermittent Catheters and Male External or Condom ... and Forecast 2014 - 2020" report to their ... market for urinary catheters is experiencing a healthy growth ...
(Date:1/23/2015)... , Jan. 23, 2015 More than a third ... quarter of those with private insurance, filled a prescription for ... a report in this week,s Morbidity and Mortality Weekly Report ... care providers to treat moderate to severe pain.  They are ...
(Date:1/23/2015)... , Jan. 23, 2015  Now available for sale, The ... support that prevents ankle sprains by cushioning the ankle ... fits securely around the outside of any shoe type ... comfort while still offering protection against sprains. With customers ...
Breaking Medicine Technology:Urinary Catheters Market (Indwelling or Foley Catheters, Intermittent Catheters and Male External or Condom Catheters) - Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 2Urinary Catheters Market (Indwelling or Foley Catheters, Intermittent Catheters and Male External or Condom Catheters) - Global Industry Analysis, Size, Share, Growth, Trends and Forecast 2014 - 2020 3Opioid painkillers widely prescribed among reproductive age women 2Opioid painkillers widely prescribed among reproductive age women 3The Armor1 Ankle Roll Guard is the New Breakthrough Solution for Ankle Sprain Prevention! 2
... Nov. 14, 2011 Regado Biosciences, Inc., a privately ... with active control agents, announces one poster presentation ... Association (AHA) Scientific Sessions meeting on November 14, ... EST session.  All three presentations highlight results from ...
... Corporation ("the Company"), a leading international manufacturer, marketer, and ... today announced its 2011 third quarter financial results. ... For the third quarter of 2011, the ... of 7.8% versus net sales of $223.7 million in ...
Cached Medicine Technology:Regado Biosciences, Inc. Presents Three Abstracts Pertaining to its Pipeline of Reversible Antithrombotic Agents, Including the Substudy Analyses of its Phase 2b RADAR Trial for REG1, its Lead Product Candidate, at the American Heart Association (AH 2Regado Biosciences, Inc. Presents Three Abstracts Pertaining to its Pipeline of Reversible Antithrombotic Agents, Including the Substudy Analyses of its Phase 2b RADAR Trial for REG1, its Lead Product Candidate, at the American Heart Association (AH 3Regado Biosciences, Inc. Presents Three Abstracts Pertaining to its Pipeline of Reversible Antithrombotic Agents, Including the Substudy Analyses of its Phase 2b RADAR Trial for REG1, its Lead Product Candidate, at the American Heart Association (AH 4Pregis Announces Third Quarter 2011 Financial Results 2Pregis Announces Third Quarter 2011 Financial Results 3Pregis Announces Third Quarter 2011 Financial Results 4Pregis Announces Third Quarter 2011 Financial Results 5Pregis Announces Third Quarter 2011 Financial Results 6Pregis Announces Third Quarter 2011 Financial Results 7Pregis Announces Third Quarter 2011 Financial Results 8Pregis Announces Third Quarter 2011 Financial Results 9Pregis Announces Third Quarter 2011 Financial Results 10Pregis Announces Third Quarter 2011 Financial Results 11Pregis Announces Third Quarter 2011 Financial Results 12
... Bio-Dot SF (slot format) microfiltration units provide ... nucleic acid in solution onto nitrocellulose or ... accommodated by using interchangeable templates to form ... format Bio-Dot SF apparatus. Each is available ...
... Disposable, clear, APET plastic tray. Small ... includes stickers to identify those trays used ... facilitate pouring off liquid. A marker or ... is designed for stacking trays on rockers ...
... porous vacuum plate, reservoir seal O-ring, sealing frame, ... 785 vacuum blotter quickly and efficiently transfers DNA ... nylon membrane. Because it generally requires only 90 ... be separated on a gel, transferred to a ...
... Includes vacuum pump, vacuum regulator. The ... transfers DNA or RNA from an agarose ... generally requires only 90 min for transfer, ... on a gel, transferred to a membrane, ...
Medicine Products: