Navigation Links
Small molecule inhibitor shows promise in trastuzumab-resistant metastatic breast cancer
Date:5/28/2009

ORLANDO (June 1, 2009)Fox Chase Cancer Center researchers report that a combination of trastuzumab and neratinib (HKI-272) a novel small molecule inhibitor of the HER2 receptor (ErbB2) appears active in women with HER2-positive metastatic breast cancer who have progressed on previous trastuzumab based therapies. More than one-quarter of the women in a phase I/II trial had their tumors shrink on the combination therapy.

"I think this is very promising. Neratinib induces clinically meaningful responses," says Ramona Swaby, M.D., a medical oncologist and attending physician at Fox Chase. Swaby will present the study results on Monday, June 1, at the annual meeting of the American Society of Clinical Oncology.

Trastuzumab is standard therapy for women with HER2-positive metastatic breast cancer and the majority of women respond to the treatment. However, over time some women will develop resistance to the drug and their tumors will start to grow again. For these women, alternative therapies are needed.

Both trastuzumab and neratinib inhibit the HER2 receptor expressed on the surface of HER2-positive breast cancer cells. Trastuzumab blocks the extracellular portion of the receptor, while neratinib blocks the intracellular portion. Researchers think that the combination may provide the one-two punch necessary to knock out the tumor cells.

Forty-five women with trastuzumab-resistant breast cancer enrolled in the trial. In the phase I portion of the trial, women received either 160 mg or 240 mg neratinib daily plus trastuzumab 4 mg/kg IV loading dose followed by 2 mg/kg weekly. None of the patients experienced dose limiting toxicities. The most common grade 3/4 adverse events included diarrhea (13%), nausea (4%) and vomiting (4%). The researchers saw no evidence of cardiac toxicity with the combination.

Of the 33 patients in the phase II portion of the trial who are evaluable for response, nine (27%) had an objective resp
'/>"/>

Contact: Frank Hoke
Franklin.Hoke@fccc.edu
215-475-2888
Fox Chase Cancer Center
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Lingraphica introduces the SmallTalk mobile accessory for aphasia
2. National Small Business Week Update: Sam's Club Announces Simplified Small Business Membership; Partnership With U.S. Chamber of Commerce, Plus Free One-Day Pass
3. Indias Non-Small-Cell Lung Cancer Drug Market Will Almost Double by 2013
4. Scientists discover how smallpox may derail human immune system
5. Make No Small Plans: M. D. Anderson Cancer Center Endeavors to Make Cancer History
6. Veterans Administration Awards Small Business' $13 Million Contract to Digitize Veterans Health Records
7. Cardinal Health to Offer Allscripts Electronic Health Record to Solo and Small Physician Groups
8. Chinese Non-Small-Cell Lung Cancer Drug Market Will More Than Double by 2013
9. BlueChoice HealthPlan Adds Coverage for Young Adults and New Plans for Small Businesses
10. Exercise programs may improve symptoms in non-small cell lung cancer patients
11. Scope of Swine Flu Outbreak in Mexico Might Be Smaller Than Thought
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... (PRWEB) July 11, 2014 Global enterprises ... services to outsource day-to-day management activities. Managed services offer ... additional expenses. The economic slowdown resulted into rising operational ... and expenses is considered to be the global market ... future. , The global managed services market is estimated ...
(Date:7/11/2014)... HOUSTON (July 10, 2014) Obese and ... from their health care providers, according to new ... Center at Houston (UTHealth). , National guidelines state ... on the importance of maintaining a healthy weight. ... events are the leading cause of line-of-duty deaths ...
(Date:7/11/2014)... (HealthDay News) -- Prostate cancer patients are more likely ... treatment and die sooner if they also have depression, ... more than 41,200 American men who were diagnosed with ... them through 2009. Nearly 1,900 of the patients had ... their prostate cancer was discovered. "Men with intermediate- ...
(Date:7/11/2014)... Europe is one of the largest ... hence, irrigated land area. The agricultural sector is a ... around 30.0% of the total water use. The scale ... southern region, but far from negligible in most northern ... over 60.0% of the water use in most countries, ...
(Date:7/11/2014)... a history of hazardous or binge drinking reduced their ... mobile phone text messages following a visit to the ... in Annals of Emergency Medicine (" A ... Patients: A Randomized Clinical Trial "). , "Each day ... to 24 visit ERs and up to half have ...
Breaking Medicine News(10 mins):Health News:North America Managed Services Market Worth $68.65 Billion by 2018 - New Report by MicroMarket Monitor 2Health News:North America Managed Services Market Worth $68.65 Billion by 2018 - New Report by MicroMarket Monitor 3Health News:North America Managed Services Market Worth $68.65 Billion by 2018 - New Report by MicroMarket Monitor 4Health News:Depression May Make It Harder to Beat Prostate Cancer 2Health News:Europe Micro Irrigation System Market Driven by Growing Environmental Concerns and Decreasing Water Availability - New Report by MicroMarket Monitor 2Health News:Europe Micro Irrigation System Market Driven by Growing Environmental Concerns and Decreasing Water Availability - New Report by MicroMarket Monitor 3Health News:Text message medicine: Texts from the ER can reduce binge drinking 2
... men who smoke had less risk of undergoing total joint ... that men who were overweight, or who engaged in vigorous ... this study are now available in Arthritis & Rheumatism ... College of Rheumatology (ACR). Research has shown that ...
... , THURSDAY, July 7 (HealthDay News) -- Suicide ... financial crisis, while road deaths decreased, according to researchers. ... percent relative increase) between 2007 and 2009. At the same ... in suicide rates seen in EU countries before 2007. ...
... belief, so-called hypoallergenic dogs do not have lower household allergen ... study by Henry Ford Hospital researchers who sought to evaluate ... home than other dogs. Hypoallergenic dogs are believed to produce ... findings are to be published online this month in the ...
... and treatment of pediatric leukemia at St. Jude Children,s Research ... M. Stratton Medal from the American Society of Hematology (ASH). ... fight against this blood cancer during the past three decades. ... of Grune and Stratton, the medical publishing house that first ...
... be reached in time to avert an unprecedented suspension of ... Medicaid and other federal health programs," Virginia Hood, MBBS, ... told the president, vice president and Congressional leaders today. ... legislation to increase the debt ceiling linked to an agreement ...
... Kathleen Doheny HealthDay Reporter , THURSDAY, July ... dignity therapy helped terminally ill patients improve their quality ... changing how their family sees and appreciates them, according ... however, ease those distressed by dying, as the researchers ...
Cached Medicine News:Health News:Male smokers less likely to need joint replacement surgery of hip or knee 2Health News:Europe's Suicides Up, Road Deaths Down After Economy Tanked 2Health News:Study: Hypoallergenic dogs not less allergic than other dogs 2Health News:Ching-Hon Pui, M.D., honored by the American Society of Hematology for work in childhood cancer 2Health News:Debt ceiling agreement 'essential' to prevent disruption of care for Medicare & Medicaid patients 2Health News:Debt ceiling agreement 'essential' to prevent disruption of care for Medicare & Medicaid patients 3Health News:Special Talk Therapy Seems to Help Dying Patients 2Health News:Special Talk Therapy Seems to Help Dying Patients 3
(Date:7/11/2014)... 2014 According to a new ... Market (Endoscopes, Endoscopic Operative Devices, and Visualization Systems) - ... 2013-2019" the global endoscopy devices market was valued at ... grow at a CAGR of 6.8% from 2013 to ... billion in 2019. Browse the full Endoscopy ...
(Date:7/10/2014)... India , July 11, 2014  Major ... treatment of cancer are being highlighted in a ... Mumbai from 10-12 July, 2014.  Renowned national ... to share best practices and exchange knowledge on ... precise, accurate and efficient. The ...
(Date:7/10/2014)...  RESMED INC. (NYSE: RMD ) today announced ... ended June 30, 2014 results on Thursday, July 31, 2014, ... release with ResMed,s results will be issued after 1:00 p.m. ... to discuss operating results and future outlook. The ... Pacific Time and the live webcast of the call can ...
Breaking Medicine Technology:Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 2Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 3Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 4Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 5Global Endoscopy Devices Market is Expected to Reach USD 36.9 Billion by 2019: Transparency Market Research 6Improving quality and access to advanced cancer care in India and South Asia 2Improving quality and access to advanced cancer care in India and South Asia 3Improving quality and access to advanced cancer care in India and South Asia 4Improving quality and access to advanced cancer care in India and South Asia 5ResMed To Announce Fourth Quarter And Fiscal Year-End 2014 Results 2
... Soligenix, Inc. (OTC Bulletin Board: SNGX ) ... today that it has appointed Kevin Horgan, MD, as ... Horgan is a board-certified gastroenterologist with a research background ... patients with inflammatory bowel disease, including graft-versus-host disease (GVHD). ...
... JOLLA, Calif., Feb. 1, 2011 Transdel Pharmaceuticals, ... a specialty pharmaceutical company focused on developing topically ... announced that the Company has been exploring strategic alternatives ... American MedTech Advisors and ESC Advisors, a division ...
Cached Medicine Technology:Soligenix Appoints Kevin Horgan, MD, as Chief Medical Officer 2Soligenix Appoints Kevin Horgan, MD, as Chief Medical Officer 3Soligenix Appoints Kevin Horgan, MD, as Chief Medical Officer 4Transdel Pharmaceuticals Announces Exploration of Strategic Alternatives 2Transdel Pharmaceuticals Announces Exploration of Strategic Alternatives 3
... 10.1 kg, Interior Dimensions (WxDxH): 31.1 x ... (WxDxH): 44.6 x 22.4 x 20.5 cm, ... 2 - 300 x 35 mm bottles, ... or 1 - 240 x 80 mm ...
... four basic components: sample well plate, filter support ... diagram). The sample well plate is available in ... (see below). All three plates are interchangeable and ... conjunction with a complete system. The tension on ...
... SF (slot format) microfiltration units provide a ... acid in solution onto nitrocellulose or Zeta-Probe ... by using interchangeable templates to form the ... Bio-Dot SF apparatus. Each is available as ...
Dot Blotter - 96-Well Dot Blot...
Medicine Products: