Navigation Links
Small Increase in Diabetes Risk Noted in Statin Patients
Date:2/16/2010

For many, benefits of lowering cholesterol outweigh drugs' downsides, researchers say

TUESDAY, Feb. 16 (HealthDay News) -- The use of cholesterol-lowering statin drugs increases the chance of developing diabetes by 9 percent, but the absolute risk is low, especially when compared with how much statins reduce the threat of heart disease and heart attack, new research shows.

The researchers analyzed data from 13 clinical trials of statins conducted between 1994 and 2009. The trials included a total of 91,140 people. Of those, 2,226 participants taking statins and 2,052 people in control groups developed diabetes over an average of four years.

Overall, statin therapy was associated with a 9 percent increased risk of developing diabetes, but the risk was higher in older patients. Neither body mass index nor changes in LDL (bad) cholesterol levels appeared to affect the statin-associated risk of developing diabetes.

There's no evidence that statin therapy raises diabetes risk through a direct molecular mechanism, but this may be a possibility, said study authors Naveed Satar and David Preiss, of the University of Glasgow's Cardiovascular Research Center, and colleagues.

The researchers noted that slightly improved survival among patients taking statins doesn't explain the increased risk of developing diabetes. They added that while it's highly unlikely, the increased risk of diabetes among people taking statins could be a chance finding.

To put their findings in context, the study authors pointed out that if 255 patients took statins for four years, there would be only one extra case of diabetes. However, for each millimole per liter reduction in LDL cholesterol achieved by taking statins, the same 255 patients would experience five fewer major coronary events, such as coronary heart disease death or non-fatal heart attack.

"In view of the overwhelming benefit of statins for reduction of cardiovascular events, the small absolute risk for development of diabetes is outweighed by cardiovascular benefit in the short and medium term in individuals for whom statin therapy is recommended," the researchers wrote in a news release.

"We therefore suggest that clinical practice for statin therapy does not need to change for patients with moderate or high cardiovascular risk or existing cardiovascular disease. However, the potentially raised diabetes risk should be taken into account if statin therapy is considered for patients at low cardiovascular risk or patient groups in which cardiovascular benefit has not been proven," they concluded.

The study authors also recommended monitoring of older people taking statins, since they have a higher risk of developing diabetes.

The findings were published online Feb. 16 and will appear in an upcoming print issue of The Lancet.

The benefit of taking statins to reduce cardiovascular risk greatly outweighs the risk of developing diabetes by a ratio of about 9:1, Dr. Christopher P. Cannon, of the cardiovascular division at Brigham and Women's Hospital and Harvard Medical School in Boston, wrote in an accompanying comment article.

"Nonetheless, this newly identified risk does warrant monitoring, and as such, in addition to periodic monitoring of liver-function tests and creatine kinase, it seems reasonable to add glucose to the list of tests to monitor in older patients on statins," Cannon said.

More information

The U.S. Food and Drug Administration has more about statins.



-- Robert Preidt



SOURCE: The Lancet, news release, Feb. 16, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Certain genetic profiles associated with recurrence-free survival for non-small cell lung cancer
2. Genes Play Role in Prognosis With Non-Small Cell Lung Cancers
3. IPC The Hospitalist Company, Inc. to Present at Deutsche Bank 2010 Small and Mid Cap Conference
4. Omnetics Nano-to-Flex Connectors Solve Big Problems in Small Spaces
5. Even a Small Dietary Reduction in Salt Could Mean Fewer Heart Attacks, Strokes and Deaths
6. Small Cuts in Salt Intake Spur Big Drops in Heart Trouble
7. NSBA 2009 Year-End Economic Report: Small Businesses Still Struggling
8. Union Tax Deal a Slap in the Face to Small Business
9. NSBA Unveils Small Business Health Care Reform Checklist
10. Small Businesses In Singapore Outmarkets & Outperforms Bigger Players in Tough Economy With Online Marketing
11. 83 Percent of Small Businesses Say No to Health Care Public Option, 89 Percent Say Government Cannot Provide Adequate Health Care
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/9/2016)... ... December 09, 2016 , ... Flottman ... and outserts. As a means of expanding capabilities Flottman has added a ... to individually code professional inserts (PIs) and patient package inserts (PPIs) that will ...
(Date:12/9/2016)... ... December 09, 2016 , ... Mediaplanet today announces distribution of ... while encouraging readers to sign up as an organ donor for the 123,000 people ... , An organ donor can save up to 8 saves through organ donation and ...
(Date:12/8/2016)... ... December 08, 2016 , ... The West ... January 1, 2017. The name change aligns the entire company with its ... health care quality. , “We are very proud of the achievements associated with ...
(Date:12/8/2016)... JENNERSVILLE, Pa. (PRWEB) , ... December 08, 2016 ... ... Penn Medicine Southern Chester County, a Property owned by an affiliate of Seavest, ... 72,000 square foot Penn Medicine Southern Chester County ambulatory care center (ACC) was ...
(Date:12/8/2016)... ... December 08, 2016 , ... Premier Fitness Camp (PFC) ... , the ultimate weight loss and wellness program, at their world headquarters of Omni ... provide immediate and long-term results to anyone seeking weight loss, personal development, a healthy ...
Breaking Medicine News(10 mins):
(Date:12/8/2016)... NEW YORK , Dec. 8, 2016 ... ... such as reducing loss of blood during surgeries, lowering the ... surgeries, and decreasing risks of SSIs. The patient warming systems ... and intravascular warming systems.These benefits in turn reduce the stay ...
(Date:12/8/2016)... -- KEY FINDINGS North America ... in 2016 and is expected to continue in the ... large number of surgical procedures that are taking place ... the patient temperature management market.) Patient warming and cooling ... blood during surgeries, lowering the risks of neurological disorders ...
(Date:12/8/2016)... Research and Markets has announced the addition of the "Endodontic Supplies - ... ... worldwide markets for Endodontic Supplies in US$ Thousand. The report provides separate comprehensive ... , Europe , Asia-Pacific , ... forecasts are provided for the period 2015 through 2022. Also, a six-year historic ...
Breaking Medicine Technology: