Navigation Links
Small Doses of Carbon Monoxide Might Help Stroke Victims
Date:12/16/2008

Mouse study showed it reduced brain damage after attack

TUESDAY, Dec. 16 (HealthDay News) -- It's a potentially lethal gas, but small amounts of carbon monoxide (CO) may help prevent brain damage after a stroke, Johns Hopkins researchers report.

CO, a colorless, odorless gas that can cause organ damage and death, is found in combustion fumes, such as those made by heating systems, vehicles and gas ranges. In enclosed or semi-enclosed places with poor ventilation, CO can build up and pose a serious threat.

The Hopkins team found that low amounts of inhaled carbon monoxide reduced brain damage by as much as 62.2 percent in mice with strokes induced by briefly blocking an artery to one side of the brain. The researchers believe that CO can protect nerve cells from damage.

"CO is made naturally by the body and can serve a protective function under various circumstances. The idea for our experiment was to see if external CO could have a similar effect," study author Sylvain Dor, an associate professor in the department of anesthesiology and critical care medicine, said in a Hopkins news release.

After strokes were induced in the mice, they were exposed to either 125 parts per million (ppm), 250 ppm of CO, or air. Each group of mice was tested for post-stroke brain damage and function, mainly by observing their running patterns and reactions to certain stimuli.

Brain damage in the side of the brain where blood supply was cut off was 49.9 percent in mice exposed only to air, 33.9 percent in mice exposed to 125 ppm of CO, and 18.8 percent in mice exposed to 250 ppm of CO. Compared to those exposed only to air, the mice exposed to CO had significantly better neurological function test scores.

The protective effect was evident in mice treated at both one and three hours after stroke. This is an important point, because "many stroke victims will not receive immediate treatment," Dor said.

The researchers said CO's protective effect may be due to:

  • Its ability to dilate blood vessels, which increases blood flow.
  • Its anti-inflammatory properties, which prevent cell death by inflammation.
  • Its capacity to reduce water in the brain. Excessive water in the brain increases intracranial pressure, which kills brain cells.

The study was published in the Dec. 15 online issue of Neurotoxicity Research.

Each year in the United States, about 700,000 people have a stroke. Of those, 87 percent suffer an ischemic stroke, caused by a blocked artery.

More information

The U.S. Environmental Protection Agency has more about carbon monoxide.



-- Robert Preidt



SOURCE: JAMA/Archives journals, news release, Dec. 15, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Prophylactic cranial irradiation in small cell lung cancer significantly increases survival
2. Governor Rendell Announces $2.1 Million Investment in Small Transit Vehicles
3. Karen Vigil Named Senior Vice President and Chief Executive Officer, Blue Shield of Californias Individual, Small Group, and Government Business Unit
4. Small Incisions Make Heart Valve Surgery Safer
5. American Red Cross and FedEx Announce Collaboration to Help Small Businesses Get Prepared for Disaster
6. Smaller breast reduction surgeries provide health benefits and should be reimbursed
7. Exponent to Present at the Upcoming Sidoti & Company Investor Forum and William Blair Small-Cap Growth Stock Conference
8. Activate America(R) Brings Together YMCAs Nationwide to Promote Small Steps Toward a Healthier Lifestyle During America on the Move Week With the YMCA, September 22-29, 2007
9. Small Bone Innovations Introduces the Artelon(R) STT Spacer to Increase Treatment Options for Thumb Arthritis
10. Small Army Takes on Cure for Diabetes and New Approach to Ending World Poverty with Addition of Non-Profit Accounts
11. Small Town Doctor Takes on Giants in Consumer Healthcare
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Small Doses of Carbon Monoxide Might Help Stroke Victims
(Date:5/3/2016)... ... May 03, 2016 , ... Calvary Hospital recently hosted a ... Hospice (DGH), a 10-bed unit located at Mary, Manning Walsh Home (MMW) in Manhattan. ... performs at DGH for half an hour, once a week. The music brings a ...
(Date:5/3/2016)... ... May 03, 2016 , ... Sandbox, one of ... to serve in the newly created position of executive vice president, chief creative ... efforts in the Chicago and LA offices. He reports to Nancy Finigan, president ...
(Date:5/3/2016)... ... May 03, 2016 , ... ... has announced today the launch of its Associates and Bachelor's degrees in Health ... of The Rockefeller University, Dr. Torsten N. Wiesel; Chairman and CEO of Fortune ...
(Date:5/3/2016)... , ... May 03, 2016 , ... Each year, about ... cause of death across the United States and account for one death every four ... impairments or are permanently disabled. HCR ManorCare is launching a video series called “Your ...
(Date:5/3/2016)... ON (PRWEB) , ... May 03, 2016 , ... ... recognized as one of Canada’s top Information and Communication Technology (ICT) companies in ... Canadian and Multinational ICT companies operating in Canada, as ranked by revenue. ...
Breaking Medicine News(10 mins):
(Date:5/3/2016)... from Sino-German High-Tech Fund to further expand product development, strengthen its disease modeling capabilities and increase market presence. ... ... ... ... Sino-German High-Tech ...
(Date:5/3/2016)... , May 3, 2016   BIOTRONIK , ... today announced Food and Drug Administration (FDA) approval ... that provides heart failure patients with access to ... also have remote monitoring with daily automatic transmission ... heart rate in response to physiological demands. ...
(Date:5/3/2016)... , May 3, 2016   Diplomat Pharmacy, Inc. (NYSE: DPLO) announced today that it is ... a video of two patients who tell their personal story and encourage those at risk ... Meet Jacque: Hepatitis C ... ... Diplomat Specialty Pharmacy (PRNewsFoto/Diplomat Pharmacy, Inc.) ...
Breaking Medicine Technology: