Navigation Links
Smac-ing lung cancer to death
Date:11/12/2007

Howard Hughes Medical Institute researchers have developed a small molecule that can turn the survival signal for a variety of cancer cells into a death signal. The molecule mimics the activity of Smac, a protein that triggers the suicide of some types of cancer cells.

The researchers say their findings suggest that Smac-mimetic compounds could be useful as targeted cancer treatments for lung and other cancers. Such therapy may be less toxic to healthy cells than current compounds used in cancer chemotherapy.

The researchers, led by Howard Hughes Medical Institute investigator Xiaodong Wang, published their findings in the November, 2007, issue of the journal Cancer Cell. Wang is at the University of Texas Southwestern Medical Center.

Cells that are defective or that become unnecessary during growth and development are induced to commit suicide through a finely balanced process known as apoptosis, or programmed cell death. A protein called Smac, which is a shortened version of second mitochondria-derived activator of apoptosis, is a part of the cells programmed cell death machinery. When that machinery is switched on, Smac is released from the mitochondria and triggers the pathway that kills damaged or abnormal cells. Cancer cells, however, can survive Smacs death signal by switching off the apoptotic machinery.

To see if they could get around this problem, Wang and other researchers have developed small-molecule mimetics of Smac that can enter the cell and trigger apoptosis. These mimetic molecules do their damage without the need for the Smac signal from the mitochondria. In earlier studies, Wang and his colleagues found that a Smac mimetic that they developed in the lab could kill cancer cells in culture. But they found that the cancer cells are only killed when the mimetic molecule is introduced in conjunction with another component of the apoptotic machinery known as TNF.

In the new studies published in Cancer Cell, Wang an
'/>"/>

Contact: Jennifer Michalowski
michalow@hhmi.org
301-215-8576
Howard Hughes Medical Institute
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Conventional prognostic factors fail to explain better prostate cancer survival in most Asian men
2. Survival differences by race most apparent in advanced stages of breast cancer
3. MRI finds breast cancer before it becomes dangerous
4. Investigators uncover intriguing clues to why persistent acid reflux sometimes turns into cancer
5. Pathway links inflammation, angiogenesis and breast cancer
6. Radiologists encouraged to look beyond cancer for clinically unseen diseases
7. Diet high in meat, fat and refined grains linked to risk for colon cancer recurrence, death
8. Immune deficiency linked to a type of eye cancer
9. Drop in breast cancer incidence linked to hormone use, not mammograms
10. Breast cancer prevention practices vary across Canada
11. First biomarker discovered that predicts prostate cancer outcome
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/22/2014)... 22, 2014 Luxury Linen purveyor Peacock ... of Dallas to provide logistics and support for one ... Alley has a long history of giving back to the ... of this year's Toy Drive were Whataburger® and 99.5 The ... than the holidays. Providing gifts to children who would otherwise ...
(Date:12/22/2014)... NAPW honors Cheryl A. ... Year. She is recognized with this prestigious distinction for ... organization of professional women in the country, spanning virtually ... Women is a vibrant networking community with over 600,000 ... is passionate and committed to best practices that support ...
(Date:12/22/2014)... Washington, DC (PRWEB) December 22, 2014 ... Nursing Leadership Conference, next month in San ... strategies to address dynamics that often stand in ... authority, and competition. , This premier faculty ... Center for Transformational Leadership, whose mission is to ...
(Date:12/21/2014)... (PRWEB) December 22, 2014 Recently, BambooFlooringChina.com, ... durable strand woven bamboo flooring collection , and launched ... 25%. The promotion is valid until Jan. 30, 2015. ... woven bamboo is the hardest bamboo flooring available today; ... resembling that of traditional teak hardwoods. Strand woven bamboo ...
(Date:12/21/2014)... Khanna Vision Institute is pleased to announce ... Helicopters holiday event for underprivileged kids. The highlight was ... by an aspen helicopter pilot. In the cover of ... was visible.(please see accompanying video). Helicopter pilots require great ... many pilots with Pi in eye vision correction. ...
Breaking Medicine News(10 mins):Health News:Peacock Alley and Community Partners of Dallas Fulfill an Estimated 12,000 Holiday Wishes for Deserving Children 2Health News:National Association of Professional Women Announces Cheryl A. Kreider, President / CEO of Kreider Health Solutions, LLC, a 2014 Professional Woman of the Year 2Health News:2015 NLN Leadership Conference February 5-7 San Antonio 2Health News:2015 NLN Leadership Conference February 5-7 San Antonio 3Health News:BambooFlooringChina.com Announced Its Durable Strand Woven Bamboo Flooring Collection 2
... for many with low risk disease, researchers find , ... prostate cancer that has a low risk of progression, ... a suitable treatment option, according to a large-scale study ... to treat localized prostate cancer is controversial because, especially ...
... ... Ridgway, MD is now performing a new procedure at Baptist Medical Center in Jackson, ... is referred to as a myomectomy, or fibroidectomy. , ... Jackson, MS (Vocus) June 18, 2010 -- Baptist ...
... families need extra support, study says , FRIDAY, June ... are at increased risk for falling behind in reading ... the American Speech-Language-Hearing Association. , Parents should provide these ... ASHA, which offers the following tips: , Talk ...
... 18 June 2010: There is significant disparity between ,richer, ... to biological treatments for rheumatoid arthritis (RA), according to ... today at EULAR 2010, the Annual Congress of the ... from a separate study show that RA patients report ...
... ... environment, many Adult Learners contact a “For Profit” Online University or ... about returning to school to earn their online degree. What most ... certificates, licenses earned and college level exams successfully completed can all ...
... cost increased, consumption dropped, study found , FRIDAY, June ... soft drinks may reduce consumption and help lower levels ... new study suggests. , Researchers examined what happened during ... Women,s Hospital in Boston increased the price of regular ...
Cached Medicine News:Health News:'Watchful Waiting' Often Best Strategy for Slow-Moving Prostate Cancer 2Health News:GYN Oncologist Uses da Vinci Surgical Robot to Preserve Fertility 2Health News:Country economy is a stronger predictor of therapy initiation 2Health News:College Equalizer Takes College Counseling Beyond the Status Quo to Help Adult Learners Find the Best School 2Health News:College Equalizer Takes College Counseling Beyond the Status Quo to Help Adult Learners Find the Best School 3Health News:People May Skip Soft Drinks Rather Than Pay More 2
(Date:12/22/2014)... NxStage Medical, Inc. (NASDAQ: NXTM ... announced today that the U.S. Food and Drug ... perform hemodialysis overnight while the patient is at ... System One is the first and only hemodialysis ... Home nocturnal hemodialysis is an ...
(Date:12/22/2014)... Tenn. , Dec. 22, 2014   TRU-D ... automated, no-touch UV disinfection robot, announced today that the ... Schedule contract through November 2019.   This ... rapidly engage all levels of government purchasers, including Department ... as well as Homeland Security contacts purchasing solutions for ...
(Date:12/22/2014)... Cyberonics, Inc. (NASDAQ: CYBX ), a global leader ... today announced it will participate in the 33 rd ... in San Francisco . ... speak at 11:00 AM Pacific Time.  A live audio webcast ... Investor Relations link on the Cyberonics home page at ...
Breaking Medicine Technology:NxStage Receives FDA Clearance for Home Nocturnal Hemodialysis 2NxStage Receives FDA Clearance for Home Nocturnal Hemodialysis 3TRU-D SmartUVC LLC Awarded General Services Administration Contract to Expand Government Customer Base 2
... BELLEVILLE, Ontario, Feb. 17, 2011 Endo Pharmaceuticals (Nasdaq: ... (TSX and ASX: BNC) today announced plans for peer-reviewed ... first Phase III trial of the intravesical formulation of ... or EN3348. The results to be presented have ...
... RED BANK, N.J., Feb. 17, 2011 The U.S. Food ... week about metal-on-metal hip components to notify the public of ... used in total hip arthroplasty (THA).   ... symptoms which include "hip/groin pain, local swelling, numbness or changes ...
Cached Medicine Technology:Urocidin™ Phase III Clinical Trial Results to be Presented at EAU and AUA Conferences 2Urocidin™ Phase III Clinical Trial Results to be Presented at EAU and AUA Conferences 3Urocidin™ Phase III Clinical Trial Results to be Presented at EAU and AUA Conferences 4Urocidin™ Phase III Clinical Trial Results to be Presented at EAU and AUA Conferences 5Urocidin™ Phase III Clinical Trial Results to be Presented at EAU and AUA Conferences 6The FDA Releases a Public Health Statement on Metal-on-Metal Hip Implants 2
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: