Navigation Links
Slowing the allergic march
Date:8/14/2011

PHILADELPHIA - A pandemic of ailments called the "allergic march" -- the gradual acquisition of overlapping allergic diseases that commonly begins in early childhood -- has frustrated both parents and physicians. For the last three decades, an explosion of eczema, food allergies, hay fever, and asthma have afflicted children in the United States, the European Union, and many other countries.

What causes the march and how to derail it has remained elusive. Now, in this week's Nature, David Artis, PhD, an associate professor of Microbiology at the Perelman School of Medicine at the University of Pennsylvania, and a team of collaborating international scientists, identified that expression of the protein TSLP may influence susceptibility to multiple allergic diseases by regulating the maturation of basophils, an uncommon type of white blood cell. Specifically, TSLP elicits the maturation of a population of distinct basophils that promotes allergic inflammation.

"A fundamental question regarding the allergic march is if a child has eczema, for example, which is associated with TSLP production in skin cells, why would some of those children subsequently be more susceptible to other allergic diseases at different sites of the body such as the gut or the lung?" asks Artis. "Although we have known that TSLP is associated with allergic diseases for many years, how this biological messenger might influence multiple allergic diseases has been a puzzle."

The origins of the present study lie in previous reports that showed that different versions of the gene encoding TSLP, an inflammation-producing cytokine, are associated with increased susceptibility to multiple allergic disorders, and that exaggerated TSLP production is associated with asthma, eczema, and food allergies in children. Together, these studies indicate that TSLP could be a critical regulator of multiple cytokine-associated allergic inflammatory diseases.

In thi
'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Slowing the spread of drug-resistant diseases is goal of new research area
2. Smoking, Obesity Slowing U.S. Life Expectancy Gains: Report
3. Pharmaceutical conservation key to slowing rise of antibiotic-resistant infections
4. Study: Hypoallergenic dogs not less allergic than other dogs
5. Kids Eczema, Hay Fever Linked to Allergic Asthma Later
6. Childhood eczema and hay fever leads to adult allergic asthma
7. Protein associated with allergic response causes airway changes in asthma patients
8. Vaccinated children not at higher risk of infections or allergic diseases
9. Vitamin D may treat and prevent allergic reaction to mold in cystic fibrosis patients
10. Those with allergic asthma face double trouble during flu season, UT Southwestern findings suggest
11. Nuvo Research enrolls first patient in Phase 2 WF10 allergic rhinitis trial
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Slowing the allergic march
(Date:8/1/2014)... DC (PRWEB) August 01, 2014 ... Thompson (D-CA), Gregg Harper (R-MS), and Peter Welch ... 5380, the Medicare Telehealth Parity Act of 2014, ... fully support this effort to improve healthcare access ... chief executive officer of ATA. "These cost-saving provisions ...
(Date:8/1/2014)... 2014 Market Publishers Ltd announces ... been added to its catalogue. , ... (APIs), Contract Research and Manufacturing Services (CRAMS), Biosimilars, ... drivers include, among others, increasing ageing population, rising ... 2015, the pharma market in India is anticipated ...
(Date:8/1/2014)... August 01, 2014 On Monday, June ... NextGen User Symposium in San Francisco, CA. Now in ... the JW Marriott Union Square hotel. , “We are ... up to speed with ACA compliance issues,” Quirk Healthcare ... The symposium provides attendees guidance with NextGen implementation and ...
(Date:8/1/2014)... Patients with the progressive, deadly respiratory ailment known as ... to battle the disease, the U.S. Food and Drug ... new treatment, an inhaled spray called Striverdi Respimat (olodaterol) ... which is often linked to smoking, involves multiple lung ... Patients with COPD may experience a number of symptoms, ...
(Date:8/1/2014)... parents worry about their children choking on small objects or ... Such was the case for 15-month-old Landon Jones who started ... "At the time, Landon had a cold so it ... illness or choking," recalled his mother, Ula Jones. But, ... his windpipe and had to be removed via surgery. Landon ...
Breaking Medicine News(10 mins):Health News:ATA Applauds Bill on Medicare Telemedicine Improvements 2Health News:In-demand Markets Research Reports by Kelly Scientific Publications Now Available at MarketPublishers.com 2Health News:In-demand Markets Research Reports by Kelly Scientific Publications Now Available at MarketPublishers.com 3Health News:Quirk Healthcare Foundation Hosts Fifth Annual California NextGen User Symposium and Launches First Annual Florida NextGen User Symposium 2Health News:FDA Approves New Treatment for People With COPD 2Health News:Food Is a Common Choking Hazard for Kids, Doctor Says 2
... the National Academy of Sciences (IOM) in the US released ... calcium across all ages. The report is based on available ... role of these nutrients on bone health. Vitamin D deficiency ... been linked to the pathogenesis of osteoporosis and hip fractures ...
... (HealthDay News) -- A U.S. Food and Drug Administration advisory ... drugs for the prevention of prostate cancer, the third highest ... GlaxoSmithKline and Merck, respectively, are already approved to treat enlarged ... also lower the risk of prostate cancer by more than ...
... effect on our understanding of genetic biology and could usher ... review individual genome sequences to fully personalise medical treatment. ... for its $10m prize for the first privately funded company ... less than $10,000 per genome, the science writer Philip Ball ...
... Dec. 1 (HealthDay News) -- A test that measures the ... at an early stage and help doctors evaluate the effectiveness ... as early as possible -- before it destroys the optic ... the researchers, from the Bascom Palmer Eye Institute at the ...
... Reporter , TUESDAY, Nov. 30 (HealthDay News) -- Autistic children ... structure called the mitochondria, which is responsible for producing the ... defects may help to explain the onset or the severity ... the Dec. 1 issue of the Journal of the ...
... Academy of Otolaryngology Head and Neck Surgery (AAO-HNS), ... surgeons, has partnered with SAGE to publish its official ... in January 2011. A leading journal in the ... recent developments in treatment of the ear, nose, throat, ...
Cached Medicine News:Health News:IOF statement on new IOM dietary reference intakes for calcium and vitamin D 2Health News:FDA Panel to Vote on Drugs Said to Prevent Prostate Cancer 2Health News:Physicists use graphene to decode DNA 2Health News:Cell Dysfunction May Play Part in Autism 2Health News:Cell Dysfunction May Play Part in Autism 3Health News:AAO-HNSF partners with SAGE to publish Otolaryngology-Head and Neck Surgery 2
(Date:8/1/2014)... 2014  VanDeMark Chemical Inc., Lockport, ... phosgene and phosgene derivatives in North ... acquired Framochem Kft, a leading European-based manufacturer of ... . The purchase unites two companies ... the world,s largest, independent manufacturers of products based ...
(Date:8/1/2014)... PALO ALTO, Calif. , Aug. 1, ... (CFRI) today announced a partnership to expand awareness of ... through the CFChef Shares program. CFChef Shares will run ... of AbbVie,s CFChef program – an online resource for ... maintain a healthy diet by submitting recipes to the ...
(Date:8/1/2014)... India , Aug. 1, 2014  Neuland ... providing active pharmaceutical ingredients (APIs), complex ... customers located in 85 countries, today announced financial ... (FY) 2015, ended June 30, 2014. ... by work flow re-prioritization to accommodate certain customer ...
Breaking Medicine Technology:VanDeMark Chemical Inc. Acquires Framochem 2VanDeMark Chemical Inc. Acquires Framochem 3VanDeMark Chemical Inc. Acquires Framochem 4AbbVie and Cystic Fibrosis Research, Inc. (CFRI) Team Up to Raise Awareness of the Nutritional Needs of CF Patients through the CFChef Shares Program 2AbbVie and Cystic Fibrosis Research, Inc. (CFRI) Team Up to Raise Awareness of the Nutritional Needs of CF Patients through the CFChef Shares Program 3Neuland Labs Reports First Quarter Fiscal Year 2015 Financial Results 2Neuland Labs Reports First Quarter Fiscal Year 2015 Financial Results 3
... This remarkable anti-reflux valve ... plastic housing which prevents the ... closed when in sitting or ... virtually self-cleaning and interference free ...
... valve is enclosed in a ... the valve from being accidentally ... or reclining positions. The valve ... free ensuring uninterrupted flow and ...
... The VerifyNow (Ultegra) System is ... which measures platelet induced aggregation as ... system consists of an instrument, a ... assay device contains reagents based on ...
The Multiple Perfusion set provides simultaneous perfusion of the aortic root and up to three or more vein grafts. The set features an inlet port with female luer and clamp attached to an adapter whi...
Medicine Products: