Navigation Links
Slimming aid from the cell laboratory?
Date:5/7/2010

Love handles, muffin tops and stomach tires white fat tissue forms the typical curves in the notorious problem areas to store energy. Exactly the opposite happens in brown fat tissue: Instead of being stored, energy gets transformed into heat. To the dismay of many people, adults have only small amounts of this energy burner. By contrast, babies and animals in hibernation have lots of it in their bodies where it serves for heat regulation.

Researchers know that external influences can stimulate the production of brown fat tissue in animals. If rodents are kept at low temperatures, clusters of brown fat cells form amid the white fat tissue. A DKFZ research team headed by Dr. Stephan Herzig, jointly with colleagues from Munich, Marburg, Frankfurt and Lausanne, has investigated the molecular causes of this phenomenon. They discovered that the production of the COX-2 inflammation enzyme is increased in white fat tissue of mice after exposure to cold temperatures. COX-2 is well known to scientists: It regulates the key step in the biosynthesis of prostaglandins inflammation-promoting hormones which are also responsible for activating pain.

"Our recent results prove that COX-2 and prostaglandins are crucial for the formation of new brown fat tissue and, thus, also for regulating body weight," said Stephan Herzig summarizing his data. Parallel to the increase in COX-2 production in white fat tissue, there is also a rising level of the protein which biochemically transforms energy into heat and is therefore considered the most important biomarker for brown fat cells. When the investigators switched off COX-2 in the white fat tissue, however, the typical appearance of brown fat cells could no longer be stimulated by the cold.

Even without using cold temperatures the scientists were able to stimulate the formation of brown fat cell clusters in white fat tissue by boosting the COX-2 production in mice using a molecular-biological trick. The body weight of these animals was 20 percent lower than that of normal animals. Even on a calorie-rich diet they did not put on weight.

Previous studies by researchers from Finland suggest that in humans, too, the activity, i.e. heat production of brown fat tissue can be stimulated by regular stays in the cold. Stephan Herzig now plans to investigate whether COX-2 also plays the biochemical key role here. Since the formation of brown fat cells can also be stimulated in the culture dish, Herzig sees a possibility for practical use of his results. His vision is to take white fat tissue from severely obese individuals, to stimulate the formation of brown fat cells using prostaglandins in the culture dish, and then transplant them back to the patient. Thus it would be possible to help people by boosting their energy metabolism and thus making weight loss easier. Scientists estimate that a small amount of about 50 grams of brown fat tissue would be sufficient to increase a person's energy metabolism by 20 percent. This would be equal to a reduction of body weight by 20 kilograms over a period of one year.

Clinical trials with cancer patients have already indirectly revealed that COX-2 has an influence on body weight. Thus, the body weight of patients suffering from severe cancer-related wasting stabilized due to COX-2 inhibiting drugs. But a number of common pain relievers also act by inhibiting COX-2. Does that mean that users have to accept weight gain as a side effect? Herzig has good news: "So far, we have found no evidence suggesting that one has to fear gaining weight from taking these drugs."


'/>"/>

Contact: Dr. Sibylle Kohlstdt
s.kohlstaedt@dkfz.de
Helmholtz Association of German Research Centres
Source:Eurekalert

Related medicine news :

1. Slimming Solutions Celebrates 10 Years in Business with the Launch of a New Weight Loss Website
2. U of I scientist says slimming soybeans are on the horizon
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... Dickinson Insurance and Financial Services, ... preparation services, is providing an update on a charitable event that began earlier ... is a locally recognized nonprofit that provides shelter and care for animals seeking ...
(Date:10/13/2017)... ... October 13, 2017 , ... ... process to promote standards of excellence for the field of eating disorders, announces ... 22 – 25, 2018 in Orlando, Florida at the Omni Resort at ChampionsGate. ...
(Date:10/13/2017)... ... October 13, 2017 , ... Apple Rehab Shelton Lakes ... a mock evacuation of the facility as part of a disaster drill on October ... Hose EMS and Shelton City Emergency Manager, as well as the Connecticut Long ...
(Date:10/13/2017)... ... October 13, 2017 , ... Global Healthcare Management’s 4th Annual ... in Milford, NJ. This free event, sponsored by Global Healthcare Management’s CEO, Jon ... fun run is geared towards children of all ages; it is a non-competitive, non-timed ...
(Date:10/13/2017)... ... ... Journey: From the Mountains to the Mission Field”: the story of a missionary couple ... From the Mountains to the Mission Field” is the creation of published author, Carole ... and currently teaches a class of ladies at her church, which she has taught ...
Breaking Medicine News(10 mins):
(Date:9/18/2017)... 18, 2017 EpiVax, Inc. ("EpiVax") ... and immune engineering, today announced a new ... (H7N9) vaccine. ... influenza and presents a challenge for traditional ... to be effective. Using state-of-the-art bioinformatics and molecular ...
(Date:9/12/2017)... , Sept. 12, 2017   EcoVadis , the leading platform for ... the first annual edition of its Global CSR Risk and Performance Index. ... by EcoVadis, based on Scorecard Ratings that analyzed nearly 800,000 data points ... ... ...
(Date:9/12/2017)... , Sept. 12, 2017  ValGenesis Inc., the ... (VLMS), is pleased to announce the appointment of ... of its Board of Directors and Chairman of ... enables life science companies to manage their entire ... of paper in this process. Furthermore, ValGenesis VLMS ...
Breaking Medicine Technology: