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Sleeping sickness drug may provide long-term protection against skin cancer
Date:10/23/2011

s compared with people assigned to placebo," Bailey said. "What we saw was that the presumed benefit that people got in taking DFMO appeared to persist for years after stopping it."

Study limitations include that participants may have been followed differently or changed their behaviors to limit sun exposure because of being in the original study, Bailey said.

"Our data suggest that the protective event that we saw in our prospective study appears to continue and there was no evidence of any rebound effect," he said. "We did not find any evidence that the people who received DFMO were harmed [other than the original ototoxicity]."

However, Bailey cautioned, more studies are needed before DFMO can be recommended as a prophylaxis against nonmelanoma skin cancers.

He added that such prophylaxis measures are needed because public health efforts to teach people about limiting sun exposure have not resulted in fewer cases of skin cancer, with more than 2 million cases of nonmelanoma skin cancer diagnosed each year. "The incidence continues to rise despite public health efforts to get people to lessen their sun exposure," Bailey said.


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Contact: Jeremy Moore
Jeremy.Moore@aacr.org
267-646-0557
American Association for Cancer Research
Source:Eurekalert

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