Navigation Links
Sleeping sickness drug may provide long-term protection against skin cancer
Date:10/23/2011

BOSTON An antiparasitic agent used to treat African sleeping sickness might someday be used to prevent nonmelanoma skin cancers. Researchers found that DFMO, or α-difluoromethylornithine, still appeared to protect against nonmelanoma skin cancers years after people stopped taking the drug, according to a poster presented at the 10th AACR International Conference on Frontiers in Cancer Prevention Research, held Oct. 22-25, 2011.

In this follow-up study, researchers evaluated prolonged evidence of a protective effect of DFMO among 209 people who had participated in an earlier study. The researchers also wanted to ensure there were no obvious deleterious effects associated with the drug, according to Howard H. Bailey, M.D., professor of medicine, and study presenter Sarah Lamont, a medical student, both from the University of Wisconsin School of Medicine and Public Health.

The original study was a phase III, randomized, double-blind, prospective study of 291 men and women with a history of nonmelanoma skin cancer. They were assigned to either DFMO or a placebo for four to five years. At the end of the study period, researchers found a reduced skin cancer incidence among those assigned to DFMO.

"We showed a significant protective effect against basal cell carcinoma, but not a significant amount of protection against squamous cell carcinoma of the skin," Bailey said.

The main side effect was a slight ototoxicity that was found on testing, but this was not associated with a noticeable reduction in hearing by the subjects.

In the current retrospective study, researchers reviewed the electronic medical records of 209 of the original participants to establish cancer rates and to see if any other illnesses they might have developed could be attributed to DFMO.

"We found there is still evidence that the men and women assigned to DFMO for five years continued to have a lower incidence of nonmelanoma skin cancers compared with people assigned to placebo," Bailey said. "What we saw was that the presumed benefit that people got in taking DFMO appeared to persist for years after stopping it."

Study limitations include that participants may have been followed differently or changed their behaviors to limit sun exposure because of being in the original study, Bailey said.

"Our data suggest that the protective event that we saw in our prospective study appears to continue and there was no evidence of any rebound effect," he said. "We did not find any evidence that the people who received DFMO were harmed [other than the original ototoxicity]."

However, Bailey cautioned, more studies are needed before DFMO can be recommended as a prophylaxis against nonmelanoma skin cancers.

He added that such prophylaxis measures are needed because public health efforts to teach people about limiting sun exposure have not resulted in fewer cases of skin cancer, with more than 2 million cases of nonmelanoma skin cancer diagnosed each year. "The incidence continues to rise despite public health efforts to get people to lessen their sun exposure," Bailey said.


'/>"/>

Contact: Jeremy Moore
Jeremy.Moore@aacr.org
267-646-0557
American Association for Cancer Research
Source:Eurekalert

Related medicine news :

1. Sometimes Sleeping on the Job May Be a Good Thing
2. Cautionary tale for people with diabetes: Dog consumed part of a sleeping patients toe
3. Could Sleeping on Left Side Help Prevent Stillbirth?
4. Sleeping through danger: the dormouse approach to survival
5. Scientists seek urgent treatment for fatal sleeping sickness
6. Most Babies Start Sleeping Through Night at 2 to 4 Months
7. Our children arent sleeping and were medicating them
8. Sleeping well at 100 years of age: Study searches for the secrets to healthy longevity
9. National Sleep Awareness Week(R) (March 7-13): How Are You Sleeping?
10. Bed Bug Insecticides Causing Sickness, Officials Warn
11. Going Full-Tilt Into Turns May Ease Motion Sickness on Trains
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/17/2017)... MD (PRWEB) , ... January 17, 2017 , ... SC&H ... the firm as a Principal in its IT Advisory Services practice . Rossi ... recent months as market demand for strategic IT guidance grows, and the practice continues ...
(Date:1/17/2017)... ... January 17, 2017 , ... Seceon , the ... in real-time, today announced a strategic partnership with TechLab Security, a ... Seceon partners, TechLab Security has become a strategic partner and a value added ...
(Date:1/17/2017)... ... January 17, 2017 , ... The Sharie Withers Agency, a ... the latest beneficiary of their thriving community involvement program. The current campaign fundraises ... the dreams of terminally ill patients. Donations to this worthy cause may now ...
(Date:1/17/2017)... ... ... people make New Year’s resolutions or renew their commitment to better health with the start ... who want to kick off 2017 with better smiles. Dr. Mondavi is offering several promotions ... include: , , A new patient package for just $49, which ...
(Date:1/17/2017)... ... January 17, 2017 , ... Twelve ... State University’s Athletic Training Education program forged a relationship built upon the foundation ... Program, which is consists of both student members and certified members of the ...
Breaking Medicine News(10 mins):
(Date:1/17/2017)... , Jan. 17, 2017  OrthoAccel ® Technologies, ... (JCO) has published "The Effect of Vibration on ... Conducted by Dr. S. Jay Bowman , this ... II malocclusions, AcceleDent,s SoftPulse Technology ® speeds up ... also reducing the number of days to move the ...
(Date:1/17/2017)... , Jan 17, 2017 Research and Markets ... Healthcare Industry 2016-2020" report to their offering. ... The global fluoropolymer market in ... the period 2016-2020. Global Fluoropolymer Market in the ... analysis with inputs from industry experts. The report covers the market ...
(Date:1/17/2017)... 2017 Following an initial analysis, the ... Food and Drug Administration,s (FDA,s) final regulatory guidance ... by Pharmacies and Outsourcing Facilities." In its final ... pre-packaging -- which would have put patients at ... term care (LTC) pharmacies.  The ...
Breaking Medicine Technology: