Navigation Links
Sleep switch found in fruit flies
Date:6/23/2011

Rather than count sheep, drink warm milk or listen to soothing music, many insomniacs probably wish for a switch they could flick to put themselves to sleep.

Scientists at Washington University School of Medicine in St. Louis have discovered such a switch in the brains of fruit flies. In a study appearing June 24 in Science, the researchers show that a group of approximately 20 cells in the brains of fruit flies controls when and how long the flies sleep. Slumber induced through this sleep switch was essential to the creation of long-term memory, directly proving a connection between memory and sleep that scientists have long suspected.

"This is exciting because this induced sleep state so far appears to be very similar to spontaneous sleep," says Paul Shaw, PhD, associate professor of neurobiology. "That means we can manipulate these cells to explore a whole new realm of questions about the purposes of sleep. Such studies might one day lead us to more natural ways of inducing sleep in humans."

The key cells are found in an area of the fly brain known as the dorsal fan-shaped body. Scientists in Shaw's lab genetically modified the cells to increase their activity. One effect of making these cells more active was that adult flies slept for an additional seven hours a day.

When scientists added a gene that increases the cells' activity only at warmer temperatures, they could determine when and how long flies would sleep by simply adjusting the temperature in the flies' habitats.

To analyze the similarity of induced sleep to spontaneous sleep, scientists tested whether induced slumber was essential to the formation of long-term memories. In a process called courtship conditioning, male flies were exposed to other males genetically modified to make female sex pheromones.

"The subject fly will initiate courtship because of the female pheromones, but the modified male making those pheromones inevitably rejects him," says first author Jeff Donlea, PhD, now a postdoctoral research assistant at Oxford University. "This is an ecologically relevant way to test memory because a male fly in the wild needs to quickly assess whether a particular female is interested in mating so that he doesn't waste time making unproductive advances."

The researchers used a training protocol that normally only creates a memory that lasts a few hours in fruit flies. After being "rejected" multiple times over three hours, the fly learns not to make advances when he encounters the altered male again at a later time. But when scientists used the cells in the dorsal fan-shaped body to put the fly to sleep immediately after training, the fly formed a long-term memory of his experience that lasted for at least several days.

To rule out the possibility that the increased excitability of the cells could be directly responsible for the long-term memory, scientists activated the sleep-regulating cells following training but prevented the flies from sleeping. The flies did not remember the training, indicating that sleep itself was important for the consolidation of memory.

Scientists have yet to determine whether a counterpart for the dorsal fan-shaped body exists in human brains. Shaw's lab is currently working to see if the cells they singled out can be matched to other brain cell types based on the chemical messengers they produce.


'/>"/>

Contact: Michael C. Purdy
purdym@wustl.edu
314-286-0122
Washington University School of Medicine
Source:Eurekalert

Related medicine news :

1. Obstructive Sleep Apnea in Kids May Have Genetic Cause
2. Sleep HealthCenters to Sponsor North East Sleep Society 2010
3. America's Hidden Pandemic: 100 Million Suffer From Sleep Problems
4. Solutions for Sleep Problems: Harvard's Improving Sleep Special Health Report and New Sleep Apnea Video
5. Behavioral therapy improves sleep and lives of patients with pain
6. Sleep problems and sleepiness increase the risk of motor vehicle accidents in adolescents
7. Severe sleep apnea decreases frequency of nightmare recall
8. Severe Sleep Apnea Has Silver Lining
9. The role of sleep in brain development
10. Sleep More, Lose Weight – Sleeplessness Linked to Obesity
11. National Sleep Awareness Week(R) (March 7-13): How Are You Sleeping?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/12/2016)... ... 2016 , ... Each year, the American Physical Therapy Association (APTA) offers a ... Anaheim Convention Center. Almost 10,000 physical therapists across the country are expected to attend ... about their chosen field and network with their colleagues. As in years past, ...
(Date:2/12/2016)... ... ... Coco Libre, the maker of coconut water beverages with a purpose, is ... Coco Libre will offer musicians and celebrities the company’s signature Organic Coconut Water, a ... suite, held this year at the W Hollywood Hotel, has become a pre-show “must” ...
(Date:2/12/2016)... ... 2016 , ... The ThedaCare Center for Healthcare Value is ... April 5-7. The series is a multi-day, multi-workshop event designed to teach leaders ... broad range of topics, including coaching skills, the scientific method of problem solving ...
(Date:2/12/2016)... (PRWEB) , ... February 12, 2016 , ... Every winter, ... , This winter the West Penn Burn Center, part of the Allegheny ... #1, to bring you the “Space Heaters Need Space” campaign. , ...
(Date:2/12/2016)... , ... February 12, 2016 , ... AssureVest Insurance Group, ... is initiating a charity drive that will raise funds earmarked to purchase computers and ... Tayloe Elementary School. , “My school is in a low-income area and has more ...
Breaking Medicine News(10 mins):
(Date:2/12/2016)... BUDAPEST , Ungarn, February 12, 2016 ... ein Medizintechnikunternehmen, das sich auf den ungedeckten ... gab heute positive Ergebnisse seines klinischen Forschungsprogramms ... und Asthma-Patienten beschäftigt, ergab Verbesserungen ihrer respiratorischen ... Indiso ltd , ein Medizintechnikunternehmen, das ...
(Date:2/11/2016)... NEW YORK , Feb. 11, 2016 ... - Companion Diagnostics in Personalized Medicine and Cancer ... Markets. - High-Growth Diagnostic Testing Markets. - ... Cancer Testing. - Molecular Diagnostics in Genetic Testing. ... - Molecular Diagnostics Markets. - Over-the-Counter Diagnostic Products ...
(Date:2/11/2016)... Feb. 11, 2016 Stem cells are primitive ... by self-renewal and the capacity to differentiate into mature ... discovery, as the first mouse embryonic stem cells were ... until 1995 that the first culturing of embryonic stem ... were not produced until 2006 As a result of ...
Breaking Medicine Technology: