Navigation Links
Sleep researchers at SRI International identify promising new treatment for narcolepsy
Date:5/7/2014

w DTA model and the Ataxin model to compare R-baclofen against gamma-hydroxybutyrate (GHB). Sodium oxybate, the sodium salt of GHB, was approved by the FDA in 2002 as the only therapeutic for narcolepsy that simultaneously alleviates cataplexy, excessive daytime sleepiness and nocturnal sleep disruption. However, it remains unclear how this drug exerts its beneficial effects.

It was suspected that GHB works by affecting brain cells that respond to a neurotransmitter known as gamma-aminobutyric acid (GABA), which primarily functions to inhibit excitability and regulate muscle tone. To study the mechanism of action of GHB, SRI Biosciences' researchers tested R-baclofen, which blocks the GABA receptors suspected to be the target of GHB.

The research team found that R-baclofen promoted sleep time and longer bouts of wakefulness during the appropriate times for mice and also suppressed cataplexy. GHB modestly reduced cataplexy and increased sleep intensity, but did not improve other symptoms of narcolepsy to the extent that R-baclofen did. "The improvement in wakefulness that we observed after R-baclofen was a particularly unexpected and important finding," said Black.

"R-Baclofen works better than GHB in these two mouse models, but it remains to be determined whether it will work better in humans," cautioned Kilduff. "Although baclofen is already known to be safe for use in humans, the dose that is effective for spasticity may be different than the dose of R-baclofen that has the potential to treat narcolepsy."


'/>"/>

Contact: Dina Basin
dina.basin@sri.com
650-859-3845
SRI International
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Exploding head syndrome -- a real but overlooked sleep disorder
2. Despite recommendations for safer sleeping, infant deaths persist
3. Many parents dont follow safe infant sleep practices
4. Many infants still not placed on their backs to sleep
5. Better sleep predicts longer survival time for women with advanced breast cancer
6. Study shows link between sleep apnea and hospital maternal deaths
7. Extreme sleep durations may affect brain health in later life
8. Sleep disorder linked to brain disease
9. Penn researchers find link between sleep and immune function in fruit flies
10. Study links severe sleep apnea to increased risk of stroke, cancer and death
11. Fruitfly study: Epilepsy drug target implications for sleep disruption in brain disorders
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2014)... Texas (PRWEB) August 23, 2014 ... Industry” is a professional and in-depth research report ... basic Glucose Meter information, including Glucose Meter definition, ... as industry overview. This research covers the international ... global industry analysis covering macroeconomic environment & economic ...
(Date:8/22/2014)... (PRWEB) August 22, 2014 Today, Zane ... new guide on Account-Based Health Plans. , According to ... as a strategy to lower the cost of healthcare ... of medical spending accounts, however, can be confusing. , ... to learn the four main types of ABHPs. It ...
(Date:8/22/2014)... (PRWEB) August 22, 2014 MyWriters.com ... is written by marketing experts for marketers to help ... has caught the attention of Shane Michaels, prompting an ... Internet marketing in any way knows that content is ... the industry,” reports Michaels. “But even though content is ...
(Date:8/22/2014)... CA (PRWEB) August 22, 2014 Buying a ... an adult who is unsure about available coverage types by ... providing principal life insurance policy pricing to the public using ... use of this tool is free and is expected to ... available to the public throughout the U.S. The system is ...
(Date:8/22/2014)... (PRWEB) August 22, 2014 Millennium Treatment Group ... resulting in a high level of drug use among teenagers. ... fight against drug addiction and work to minimize drug abuse. ... of alcohol and drug addiction in history. According to the ... estimated 23.9 million Americans aged 12 or older—or 9.2 percent ...
Breaking Medicine News(10 mins):Health News:Glucose Meter Industry Global (Europe, Asia, NA, ROW) Analysis Now Available at ReportsnReports.com 2Health News:Glucose Meter Industry Global (Europe, Asia, NA, ROW) Analysis Now Available at ReportsnReports.com 3Health News:My Writers: Review Exposes Online Source for Quality Marketing Content 2Health News:Principal Life Insurance Policies Now Quoted for Adults at Insurance Website Online 2Health News:Millennium Treatment Group Sees Increase in Marijuana Use Among Youth 2
... pulmonary fibrosis often do not get referred to a tertiary ... a higher death rate. Better methods of early ... (NEW YORK, NY, July 1, 2011) Idiopathic pulmonary ... the predominant condition leading to lung transplantation nationwide. Columbia University ...
... have discovered the first of an entirely new class ... development of blood vessels. In a report in ... the investigators describe how a compound derived from a ... to interfere with blood vessel formation in animal models ...
... the American College of Radiology suggests that self-referral ... diagnostic imaging growth. Self-referred imaging is identified as ... to their own on-site imaging services or the referral of ... financial interest. In the current political and ...
... Reporter , THURSDAY, June 30 (HealthDay News) -- Annual low-dose ... 20 percent in heavy smokers and formerly heavy smokers, compared ... results of a major National Cancer Institute study released on ... major advance in efforts to combat lung cancer deaths. By ...
... up and down the court aspiring to NBA stardom. Now, ... to achieving their hoop dreams: sleep. In a study ... Mah, a researcher in the Stanford Sleep Disorders Clinic and ... college level were able to improve their on-the-court performance by ...
... Samuel Waxman Cancer Research Foundation have partnered to establish a ... the two Foundations are proud to announce the award of ... School of Medicine in Atlanta. Van Meir,s research aims to ... the Ewing sarcoma family of tumors (ESFT) oncoprotein. Ewing ...
Cached Medicine News:Health News:Delayed access to tertiary care associated with higher death rate from type of pulmonary fibrosis 2Health News:Mass. General team identifies new class of antiangiogenesis drugs 2Health News:Self-referral: A significant factor in imaging growth 2Health News:Who Should Get a CT Scan to Screen for Lung Cancer? 2Health News:Who Should Get a CT Scan to Screen for Lung Cancer? 3Health News:Who Should Get a CT Scan to Screen for Lung Cancer? 4Health News:Who Should Get a CT Scan to Screen for Lung Cancer? 5Health News:Snooze you win? It's true for achieving hoop dreams, says Stanford study 2Health News:Snooze you win? It's true for achieving hoop dreams, says Stanford study 3Health News:Targeting the Ewing sarcoma family of tumors 2
(Date:8/21/2014)... , N.Y. and HAMBURG, Germany , ... announced it is collaborating with Deutsches Elektronen-Synchrotron ( DESY ... Germany , to speed up management and storage ... Big Data and Analytics architecture based on IBM ... per second of data at peak performance and help ...
(Date:8/21/2014)... 21, 2014  Zacks.com announces the list of stocks featured ... analysts discuss the latest news and events impacting stocks and ... Hewlett-Packard (NYSE: HPQ - Free Report ), IBM (NYSE: ... SB - Free Report ), GlaxoSmithKline plc (NYSE: ... FI - Free Report ). Today, Zacks ...
(Date:8/21/2014)... , Aug. 21, 2014  Henry Schein, Inc. (NASDAQ: ... care products and services to office-based dental, animal health and ... two investor conferences in September: , September 4, ... York , NY at 12:50 p.m. ET , September ... in New York , NY at 1:25 p.m. ...
Breaking Medicine Technology:DESY and IBM Develop Big Data Architecture for Science 2DESY and IBM Develop Big Data Architecture for Science 3The Zacks Analyst Blog Highlights: Hewlett-Packard, IBM, Safe Bulkers, GlaxoSmithKline and Frank's International 2The Zacks Analyst Blog Highlights: Hewlett-Packard, IBM, Safe Bulkers, GlaxoSmithKline and Frank's International 3The Zacks Analyst Blog Highlights: Hewlett-Packard, IBM, Safe Bulkers, GlaxoSmithKline and Frank's International 4The Zacks Analyst Blog Highlights: Hewlett-Packard, IBM, Safe Bulkers, GlaxoSmithKline and Frank's International 5The Zacks Analyst Blog Highlights: Hewlett-Packard, IBM, Safe Bulkers, GlaxoSmithKline and Frank's International 6The Zacks Analyst Blog Highlights: Hewlett-Packard, IBM, Safe Bulkers, GlaxoSmithKline and Frank's International 7The Zacks Analyst Blog Highlights: Hewlett-Packard, IBM, Safe Bulkers, GlaxoSmithKline and Frank's International 8The Zacks Analyst Blog Highlights: Hewlett-Packard, IBM, Safe Bulkers, GlaxoSmithKline and Frank's International 9The Zacks Analyst Blog Highlights: Hewlett-Packard, IBM, Safe Bulkers, GlaxoSmithKline and Frank's International 10The Zacks Analyst Blog Highlights: Hewlett-Packard, IBM, Safe Bulkers, GlaxoSmithKline and Frank's International 11Henry Schein To Present At Two Investor Conferences In September 2
... a minimum results in less emotional trauma ... the clinician. The innovative motor plus saw ... lighter package. In addition, the unique design ... more user comfort. Plus automated multi-speed controls ...
The True/Fix Cannulated Bone Screw System contains 7.0mm large cannulated bone screws and 3.5mm cortical and 4.0mm cannulated cancellous bone screws....
LEMAIRE stapes are stainless steel staples indicated for ligament fixation....
... Osteotomies and ligament ... a small number of ... Arthrodesis is the most ... of suitable staples allow ...
Medicine Products: