Navigation Links
Sleep researchers at SRI International identify promising new treatment for narcolepsy
Date:5/7/2014

rugs that only address the symptoms, rather than the underlying causes, of narcolepsy.

In the first of the two papers, "Conditional Ablation of Orexin/Hypocretin Neurons: A New Mouse Model for the Study of Narcolepsy and Orexin System Function," Kilduff and Black teamed with colleagues at five institutions in Japan to generate a model of narcolepsy that better mimics the human disorder. The existing model, called "Ataxin mice," has been available for over 10 years. Although Ataxin mice have enabled researchers to study narcolepsy, an important limitation is that these mice are born with the deficiency of the neurotransmitter hypocretin that has been implicated in causing narcolepsy, whereas the onset of human narcolepsy typically occurs after puberty.

"The mouse model developed by Dr. Kilduff and his colleagues offers a new approach to study narcolepsy and to explore potential therapies for this devastating sleep disorder. This new model allows more precise control of the timing and extent of hypocretin/orexin neuron loss, and thus may better mimic human narcolepsy," said Janet He, Ph.D., program director at the National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health.

In collaboration with Professor Akihiro Yamanaka of Nagoya University in Japan, formerly an SRI International Fellow in Dr. Kilduff's laboratory, the research team genetically engineered a mouse in which the hypocretin neurons could be selectively eliminated at any age simply by removal of an antibiotic in the mouse food. In the new "DTA" model, degeneration of hypocretin neurons can be initiated after puberty, causing the mice to exhibit the two major symptoms of narcolepsy: excessive daytime sleepiness and cataplexy, the brief loss of muscle tone experienced by most narcoleptics.

In the second paper, "GABAB Agonism Promotes Sleep and Reduces Cataplexy in Murine Narcolepsy," Black, Kilduff and colleagues used the ne
'/>"/>

Contact: Dina Basin
dina.basin@sri.com
650-859-3845
SRI International
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Exploding head syndrome -- a real but overlooked sleep disorder
2. Despite recommendations for safer sleeping, infant deaths persist
3. Many parents dont follow safe infant sleep practices
4. Many infants still not placed on their backs to sleep
5. Better sleep predicts longer survival time for women with advanced breast cancer
6. Study shows link between sleep apnea and hospital maternal deaths
7. Extreme sleep durations may affect brain health in later life
8. Sleep disorder linked to brain disease
9. Penn researchers find link between sleep and immune function in fruit flies
10. Study links severe sleep apnea to increased risk of stroke, cancer and death
11. Fruitfly study: Epilepsy drug target implications for sleep disruption in brain disorders
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/29/2014)... Colorado (PRWEB) July 29, 2014 Daily Gossip ... a powerful and holistic system that will teach users how ... tried by thousands of people, from all over the world. ... the symptoms of this disorder in as quickly as 12 ... be gone faster than imagined. , The Fibroids Miracle ...
(Date:7/29/2014)... 29, 2014 (HealthDay News) -- Want young children to ... something that,s healthy is good for them. Doing so ... a new study suggests. "Parents and caregivers who ... be better off simply serving the food without saying ... the food actually is," said study authors Michal Maimaran, ...
(Date:7/29/2014)... Chlorine helps keep pool water clean, but it can ... doctors say. Pool swimmers can also develop ... Dr. Sampson Davis, an emergency room physician at Meadowlands ... to understand why this happens, Davis said. Swimming ... of the eye that helps protect against infection. And ...
(Date:7/29/2014)... 2014) Using quality improvement measures in eight of ... Disease Study Group, researchers have found a way to ... contrast dye. , Currently, 7-15 percent of these patients ... up with kidney injury, which can result in death ... or permanent dialysis, says a study published in the ...
(Date:7/29/2014)... July 29, 2014 Historically, Memorial Day ... United States usually celebrated throughout that time by picnics, ... summer days now mark the start of a period ... teen drivers. In 2012 nearly 1.000 people were ... from Memorial Day to Labor Day. , The summer's ...
Breaking Medicine News(10 mins):Health News:Amanda Leto’s Fibroids Miracle Review Reveals Clinically Proven Uterine Fibroids Cure System 2Health News:Kids Will Pass on 'Healthy' Foods 2Health News:Protect Your Eyes When Hitting the Pool 2Health News:Reducing kidney injury using a quality improvement method 2Health News:Narconon New Life Retreat Launches New Alcohol Prevention Program 2
... cancer has been called for by the Well Woman Centre.// ... a vaccine against cervical cancer is expected to be available in ... the development of the vaccine, Gardasil, as one of the biggest ... the vaccine were disclosed at a medical conference in Prague earlier ...
... in children that can often be disabling and one ... from school could mainly be due to their genetic// ... Medicine (Department of Psychological Medicine), in a genetic study ... usually occur together, they are of different genetic and ...
... a breakthrough, towards the testing and cure for the ... US National Institutes of Health team found women with ... before developing the condition. Reporting their findings they explained ... be responsible for virtually all cases of pre-eclampsia, which ...
... The U.N. children's agency, UNICEF and the Barcelona soccer club ... to donate $1.9 million a year over the next five// ... countries. ,Their first installment will go towards the ... Africa where around 40 percent of adults are infected with ...
... healers in Ghana claim to have developed a product ... system in much the same way as Anti-Retroviral Therapy ... ,Ghana Aids Commission (GAC), Catholic Relief Services (CRS) ... this project. Dr Anthony Normeshie, Executive Director, Health For ...
... larger number of them is experimenting with alcohol.// ... reduced number of Canadian youth are trying to smoke cigarettes ... a decade ago. ,It was announced that the ... was conducted on a survey of 29, 000 Canadian students ...
Cached Medicine News:Health News:Placental Proteins Could Be Responsible For Pre-eclampsia 2Health News:Youth Of Canada Wary Of Cigarettes But Not Of Alcohol 2
(Date:7/29/2014)... According to a new market ... Market (Neurosurgical Navigation Systems, ENT Navigation Systems and Orthopedic ... Trends and Forecast, 2014 - 2020", the global surgical ... in 2013 and is expected to grow at a ... an estimated value of USD 295.5 million in 2020. ...
(Date:7/29/2014)... 2014 Numotion,s Board of Directors has announced that ... be the company,s new Chief Executive Officer. ... GE where he worked primarily for GE Healthcare Services, running ... $5 billion. His most recent position was as President and ... am thrilled to join Numotion," said Mike Swinford . ...
(Date:7/29/2014)... 29, 2014 McGraw-Hill Education Professional, a leading ... technical, and medical communities, has announced the launch of ... application of the world-renowned medical education platform. ... App , available for download onto all iOS and ... to gain access to valuable AccessMedicine diagnostic ...
Breaking Medicine Technology:Surgical Navigation Systems Market Expected to Reach USD 295.5 Million Globally in 2020: Transparency Market Research 2Surgical Navigation Systems Market Expected to Reach USD 295.5 Million Globally in 2020: Transparency Market Research 3Surgical Navigation Systems Market Expected to Reach USD 295.5 Million Globally in 2020: Transparency Market Research 4Numotion Names Mike Swinford CEO 2McGraw-Hill Education Professional's AccessMedicine App Delivers Instant Access to Essential Diagnostic Tools 2McGraw-Hill Education Professional's AccessMedicine App Delivers Instant Access to Essential Diagnostic Tools 3
... GARDEN CITY, New York, Oct. 7 ... Merkin recognize and congratulate seniors enrolled with HCP, IPA ... concern, health care reform, directly to members of Congress, ... http://www.newscom.com/cgi-bin/prnh/20091007/LA89266 ) , Dr. John Gastright, Senior ...
... , WALTHAM, Mass., Oct. 7 Nova Biomedical Corporation, ... that the company,s independent, wholly owned subsidiary, Sanvita CBGM, ... Sanvita, Inc., a subsidiary of CCS Medical, Inc. ... through this transaction, Nova,s Consumer Blood Glucose Monitoring (CBGM) ...
Cached Medicine Technology:HealthCare Partners, IPA, Dr. Richard Merkin, CEO, Recognize Seniors Taking Their Healthcare Concerns Directly to Lawmakers in Washington, DC 2HealthCare Partners, IPA, Dr. Richard Merkin, CEO, Recognize Seniors Taking Their Healthcare Concerns Directly to Lawmakers in Washington, DC 3Subsidiary of Nova Biomedical Completes Acquisition of Assets of CCS Medical's Subsidiary, Sanvita, Inc. 2
Coaptation forceps. Insulated....
Titanium bayonet forceps. Insulated....
Gerald bayonet forceps. Insulated....
Insulated Bipolar Forceps...
Medicine Products: