Navigation Links
Sleep researchers at SRI International identify promising new treatment for narcolepsy
Date:5/7/2014

rugs that only address the symptoms, rather than the underlying causes, of narcolepsy.

In the first of the two papers, "Conditional Ablation of Orexin/Hypocretin Neurons: A New Mouse Model for the Study of Narcolepsy and Orexin System Function," Kilduff and Black teamed with colleagues at five institutions in Japan to generate a model of narcolepsy that better mimics the human disorder. The existing model, called "Ataxin mice," has been available for over 10 years. Although Ataxin mice have enabled researchers to study narcolepsy, an important limitation is that these mice are born with the deficiency of the neurotransmitter hypocretin that has been implicated in causing narcolepsy, whereas the onset of human narcolepsy typically occurs after puberty.

"The mouse model developed by Dr. Kilduff and his colleagues offers a new approach to study narcolepsy and to explore potential therapies for this devastating sleep disorder. This new model allows more precise control of the timing and extent of hypocretin/orexin neuron loss, and thus may better mimic human narcolepsy," said Janet He, Ph.D., program director at the National Institute of Neurological Disorders and Stroke (NINDS), part of the National Institutes of Health.

In collaboration with Professor Akihiro Yamanaka of Nagoya University in Japan, formerly an SRI International Fellow in Dr. Kilduff's laboratory, the research team genetically engineered a mouse in which the hypocretin neurons could be selectively eliminated at any age simply by removal of an antibiotic in the mouse food. In the new "DTA" model, degeneration of hypocretin neurons can be initiated after puberty, causing the mice to exhibit the two major symptoms of narcolepsy: excessive daytime sleepiness and cataplexy, the brief loss of muscle tone experienced by most narcoleptics.

In the second paper, "GABAB Agonism Promotes Sleep and Reduces Cataplexy in Murine Narcolepsy," Black, Kilduff and colleagues used the ne
'/>"/>

Contact: Dina Basin
dina.basin@sri.com
650-859-3845
SRI International
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Exploding head syndrome -- a real but overlooked sleep disorder
2. Despite recommendations for safer sleeping, infant deaths persist
3. Many parents dont follow safe infant sleep practices
4. Many infants still not placed on their backs to sleep
5. Better sleep predicts longer survival time for women with advanced breast cancer
6. Study shows link between sleep apnea and hospital maternal deaths
7. Extreme sleep durations may affect brain health in later life
8. Sleep disorder linked to brain disease
9. Penn researchers find link between sleep and immune function in fruit flies
10. Study links severe sleep apnea to increased risk of stroke, cancer and death
11. Fruitfly study: Epilepsy drug target implications for sleep disruption in brain disorders
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/25/2015)... New York (PRWEB) April 25, 2015 ... established for vaginal mesh lawsuits filed against C.R. ... U.S. District Court, Southern District of West Virginia. ... a Scheduling Conference was convened that day, after ... Master Long Form Complaint. The Order directed that ...
(Date:4/25/2015)... 25, 2015 The impact of the ... the excitement of the public and is likely to ... of May and June. From March 21st to ... tradition of "Special Prayers." More than 600 people participated ... Special Prayers and have reported intense experiences that they ...
(Date:4/25/2015)... (PRWEB) April 25, 2015 Parker and Sons ... and cooling, has spiked in Arizona alongside the growing economy. ... additional forty employees for April to help account for the ... forty employees in April is something we are enthusiastic about. ... said Paul Kelly, president at Parker and Sons. , Indeed, ...
(Date:4/25/2015)... 25, 2015 On Friday, April 17, ... Journal’s annual Best Implementation Award. This award is ... best use of RFID technology to improve its manufacturing, ... company that best demonstrates how RFID is delivering real ... RFID Journal Live! 2015 in San Diego, the RFID ...
(Date:4/24/2015)... Constellations Recovery celebrates the opening of the ... 35 miles from New York City, Constellations Recovery was ... while recovering from addiction. The Open House, which is ... doctors and treatment centers to see the residence, tour ... offered by Constellations Recovery.,  , The newly opened facility ...
Breaking Medicine News(10 mins):Health News:C.R. Bard Vaginal Mesh Lawsuit News: Federal Litigation Issues New Pretrial Order Following Submission of Amended Responses to Master Complaint 2Health News:C.R. Bard Vaginal Mesh Lawsuit News: Federal Litigation Issues New Pretrial Order Following Submission of Amended Responses to Master Complaint 3Health News:C.R. Bard Vaginal Mesh Lawsuit News: Federal Litigation Issues New Pretrial Order Following Submission of Amended Responses to Master Complaint 4Health News:Trivedi Master Wellness™ Announces the Resounding Success of their Special Prayers Human Wellness Program 2Health News:Trivedi Master Wellness™ Announces the Resounding Success of their Special Prayers Human Wellness Program 3Health News:Parker and Sons Plans to Expand in 2015 2Health News:Seeonic’s Industry Leading Technology Powers Interstate Batteries to Winning Award 2Health News:Constellations Recovery Opens The First Luxury Sober Living Residence in Westchester New York 2Health News:Constellations Recovery Opens The First Luxury Sober Living Residence in Westchester New York 3
... ... announced that nine distinguished scientists have joined its Environmental Task Force to explore possible ... IDA also announced the members of the Task Force’s Steering Committee as well as ... ...
... ... for military veterans harmed by Agent Orange. , ... Parkersburg, WV (PRWEB) April 24, 2010 -- According to attorney Jan ... and ischemic heart disease should have an easier time obtaining disability benefits under a recently ...
... for American adults have stabilized while the rate of childhood ... the journal Medical Decision Making , published by SAGE. ... from 2000-2004 and validated against 2005-2006 data, the study looked ... in the United States. The research explored statistics for many ...
... yielded best results when put in those younger ... News) -- Inserting cochlear implants early significantly improves ... who have severe hearing loss, a new study ... three years in 188 children who underwent cochlear ...
... to live together happily, experts say , FRIDAY, April 23 ... to cats, enduring regular bouts of congestion, sneezing, and watery ... as an office manager for a feline veterinary hospital in ... "They showed up and never left so I took them ...
... ... Research Council , low reimbursements from public health insurance programs, such as Medicare and Medicaid, ... forcing auto insurers to more closely scrutinize and negotiate hospital bills prior to payment. ... Malvern, PA (Vocus) April ...
Cached Medicine News:Health News:International Desalination Association Announces Members of Environmental Task Force and Dates for Environmental Symposium 2Health News:International Desalination Association Announces Members of Environmental Task Force and Dates for Environmental Symposium 3Health News:International Desalination Association Announces Members of Environmental Task Force and Dates for Environmental Symposium 4Health News:International Desalination Association Announces Members of Environmental Task Force and Dates for Environmental Symposium 5Health News:International Desalination Association Announces Members of Environmental Task Force and Dates for Environmental Symposium 6Health News:International Desalination Association Announces Members of Environmental Task Force and Dates for Environmental Symposium 7Health News:New Disability Benefits Could Soon Be Available to Vietnam Vets 2Health News:New Disability Benefits Could Soon Be Available to Vietnam Vets 3Health News:Early Surgery Best for Children With Hearing Loss 2Health News:Cat Allergy Doesn't Have to Mean Giving Up Kitty 2Health News:Cat Allergy Doesn't Have to Mean Giving Up Kitty 3Health News:Hospital Cost Shifting Adds to Auto Injury Claim Costs 2Health News:Hospital Cost Shifting Adds to Auto Injury Claim Costs 3Health News:Hospital Cost Shifting Adds to Auto Injury Claim Costs 4
(Date:4/24/2015)... DUBLIN , Apr. 24, 2015 /PRNewswire/ ... ) has announced the addition of the ... Printer/ Pipette tips/ Pumps/Microplate/Reagent Reservoir/Valve/Tubing/Wash Station) & ... Institute) - Global Forecast to 2020" ... global laboratory accessories market is expected to ...
(Date:4/24/2015)... -- Novartis Pharmaceuticals Corporation (NPC) has been named the top company ... the annual DiversityInc Top 50 Companies for Diversity listing. DiversityInc ... Diversity on April 23 at an awards ceremony in ... on the DiversityInc Top 10 Companies for Recruitment list and ... list. David Epstein , Division Head, ...
(Date:4/24/2015)... Ga. , April 24, 2015 ... researchers, paper, that such was not the product of reliable ... form a reliable basis for allegations of adulteration. ... position on a false premise, or misguided hope, ... fact, these studies are contradicted by multiple other ...
Breaking Medicine Technology:Global Lab Accessories Market Report 2015-2020 - Label Printer/ Pipette tips/ Pumps/Microplate/Reagent Reservoir/Valve/Tubing/Wash Station 2Global Lab Accessories Market Report 2015-2020 - Label Printer/ Pipette tips/ Pumps/Microplate/Reagent Reservoir/Valve/Tubing/Wash Station 3Novartis Pharmaceuticals Corporation is first company to receive number one ranking two years in a row on DiversityInc Top 50 Companies for Diversity list 2Novartis Pharmaceuticals Corporation is first company to receive number one ranking two years in a row on DiversityInc Top 50 Companies for Diversity list 3Novartis Pharmaceuticals Corporation is first company to receive number one ranking two years in a row on DiversityInc Top 50 Companies for Diversity list 4Hi-Tech Responds to "Bullying Tactics" Issued by FDA on Acacia Rigidula 2Hi-Tech Responds to "Bullying Tactics" Issued by FDA on Acacia Rigidula 3Hi-Tech Responds to "Bullying Tactics" Issued by FDA on Acacia Rigidula 4Hi-Tech Responds to "Bullying Tactics" Issued by FDA on Acacia Rigidula 5Hi-Tech Responds to "Bullying Tactics" Issued by FDA on Acacia Rigidula 6
... VALENCIA, Calif., Oct. 4, 2011 Bioness ... initial enrollment phase of the FASTEST study to further examine ... individuals with foot drop as a result of stroke. The ... L300® Foot Drop System over standard therapy with an ankle-foot ...
... Goldfarb Branham LLP is investigating whether ... PPDI ) violated shareholder protection laws by ... Concerned investors are encouraged to contact attorney Hamilton Lindley ... and remedies. "As recently as mid-August, ...
Cached Medicine Technology:Bioness Inc. Announces Completion of Enrollment in Its FASTEST L300 Study 2
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: