Navigation Links
Sleep disordered breathing is associated with an increased risk of cancer mortality
Date:5/20/2012

ATS 2012, SAN FRANCISCO Sleep disordered breathing (SDB), which is associated with an increased risk of adverse cardiovascular events and psychopathological outcomes, is also associated with an increased risk of cancer mortality, according to a new study.

"Recent in vitro and animal studies have shown that repeated episodes of hypoxia (an inadequate supply of oxygen) are associated with accelerated cancer progression," said F. Javier Nieto, MD, PhD, chair of the Department of Population Health Sciences at the University of Wisconsin School of Medicine and Public Health. "Our results are the first to suggest that SDB is also associated with an increased risk of cancer mortality in humans."

The results will be presented at the ATS 2012 International Conference in San Francisco.

The researchers examined 22-year mortality data on 1,522 subjects from the Wisconsin Sleep Cohort, a prospective, community-based study of the predictors and natural history of sleep disorders. SDB was assessed by polysomnography at baseline.

After adjustment for age, sex, body mass index, smoking and other factors, both all-cause and cancer mortality were associated with the presence and severity of SDB in a dose-response fashion. Compared to subjects without SDB, the adjusted relative hazards of cancer mortality were 1.1 for study participants with mild SDB, 2.0 for those with moderate SDB, and 4.8 for those with severe SDB.

The team of University of Wisconsin investigators led by Dr. Nieto conducted this research in collaboration with Ramon Farr, PhD, professor of Physiology at the Unit of Biophysics and Bioengineering at University of Barcelona, Spain. In a separate study which will also be presented at the ATS 2012 conference, Dr. Farr's group and colleagues at the Hospital Clnic-IDIBAPS in Barcelona follow up on their earlier mouse experimental model showing that the effect of intermittent hypoxia on cancer growth is considerably stronger in lean mice than in obese mice.

"The consistency of the evidence from the animal experiments and this new epidemiologic evidence in humans is highly compelling," said Dr. Nieto. "In vitro and animal studies suggest that intermittent hypoxia promotes angiogenesis and tumor growth, which can explain these observations."

"Ours is the first study to show an association between SDB and an elevated risk of cancer mortality in a population-based sample. If the relationship between SDB and cancer mortality is validated in further studies, the diagnosis and treatment of SDB in patients with cancer might be indicated to prolong survival," Dr. Nieto concluded. "Additional studies are needed to replicate our results and to examine the relationships between SBD, obesity, and cancer mortality."


'/>"/>

Contact: Nathaniel Dunford
ndunford@thoracic.org
212-315-8620
American Thoracic Society
Source:Eurekalert

Related medicine news :

1. Obstructive Sleep Apnea in Kids May Have Genetic Cause
2. Sleep HealthCenters to Sponsor North East Sleep Society 2010
3. America's Hidden Pandemic: 100 Million Suffer From Sleep Problems
4. Solutions for Sleep Problems: Harvard's Improving Sleep Special Health Report and New Sleep Apnea Video
5. Behavioral therapy improves sleep and lives of patients with pain
6. Sleep problems and sleepiness increase the risk of motor vehicle accidents in adolescents
7. Severe sleep apnea decreases frequency of nightmare recall
8. Severe Sleep Apnea Has Silver Lining
9. The role of sleep in brain development
10. Sleep More, Lose Weight – Sleeplessness Linked to Obesity
11. National Sleep Awareness Week(R) (March 7-13): How Are You Sleeping?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/6/2016)... IL (PRWEB) , ... May 06, 2016 , ... From ... in Chicago, IL, offering EarQ members the unique opportunity to learn more about Signia’s ... for independent practice growth. , “It is our priority to see practices succeed in ...
(Date:5/6/2016)... ... May 06, 2016 , ... Expert mattress ... , Since launching in September, 2014 Sleepopolis has resided at Sleepopolis-mattress-reviews.com . ... include pillows, sheets, mattress toppers, bed frames, and more. , Founder and Editor-in-Chief ...
(Date:5/6/2016)... Lehi, Utah (PRWEB) , ... May 06, 2016 ... ... Career Step, an online provider of career-focused education and corporate training, and the ... families, are pleased to announce Maritza Aquino as the second full-tuition scholarship recipient ...
(Date:5/6/2016)... (PRWEB) , ... May 06, 2016 , ... ... Vice President at CareFirst Blue Cross BlueShield and Former Principal Deputy Administrator at ... CareMore - an Anthem Company; Steve Ondra, MD, Chief Medical Officer at Health ...
(Date:5/5/2016)... (PRWEB) , ... May 05, 2016 , ... ... long-acting injectables (LAIs), today announced a development collaboration with the Australian ... treat serious mental disorders such as schizophrenia. , LAI medicines can offer improved ...
Breaking Medicine News(10 mins):
(Date:5/5/2016)... Calif. , May 5, 2016  Diagnostic ... a decade due to concerns that these tests ... the approach to imaging, as well as the ... new era of medical peripherals that help health care providers ...   Ampronix  advanced medical imaging is a renowned authorized ...
(Date:5/5/2016)... Research and Markets has announced the addition ... EU Markets"  report to their offering.  ,     (Logo: http://photos.prnewswire.com/prnh/20160330/349511LOGO ... the current Positron Emission Tomography (PET) scanner and cyclotron install ... includes France , Germany ... and the United Kingdom . Along ...
(Date:5/5/2016)... , May 5, 2016 ... the addition of the  "Europe Thrombocytopenia ... 2016"  report to their offering.  ... ) , ,The latest research Europe ... - 2016, provides comprehensive insights into ...
Breaking Medicine Technology: