Navigation Links
Sleep disordered breathing is associated with an increased risk of cancer mortality
Date:5/20/2012

ATS 2012, SAN FRANCISCO Sleep disordered breathing (SDB), which is associated with an increased risk of adverse cardiovascular events and psychopathological outcomes, is also associated with an increased risk of cancer mortality, according to a new study.

"Recent in vitro and animal studies have shown that repeated episodes of hypoxia (an inadequate supply of oxygen) are associated with accelerated cancer progression," said F. Javier Nieto, MD, PhD, chair of the Department of Population Health Sciences at the University of Wisconsin School of Medicine and Public Health. "Our results are the first to suggest that SDB is also associated with an increased risk of cancer mortality in humans."

The results will be presented at the ATS 2012 International Conference in San Francisco.

The researchers examined 22-year mortality data on 1,522 subjects from the Wisconsin Sleep Cohort, a prospective, community-based study of the predictors and natural history of sleep disorders. SDB was assessed by polysomnography at baseline.

After adjustment for age, sex, body mass index, smoking and other factors, both all-cause and cancer mortality were associated with the presence and severity of SDB in a dose-response fashion. Compared to subjects without SDB, the adjusted relative hazards of cancer mortality were 1.1 for study participants with mild SDB, 2.0 for those with moderate SDB, and 4.8 for those with severe SDB.

The team of University of Wisconsin investigators led by Dr. Nieto conducted this research in collaboration with Ramon Farr, PhD, professor of Physiology at the Unit of Biophysics and Bioengineering at University of Barcelona, Spain. In a separate study which will also be presented at the ATS 2012 conference, Dr. Farr's group and colleagues at the Hospital Clnic-IDIBAPS in Barcelona follow up on their earlier mouse experimental model showing that the effect of intermittent hypoxia on cancer growth is considerably stronger in lean mice than in obese mice.

"The consistency of the evidence from the animal experiments and this new epidemiologic evidence in humans is highly compelling," said Dr. Nieto. "In vitro and animal studies suggest that intermittent hypoxia promotes angiogenesis and tumor growth, which can explain these observations."

"Ours is the first study to show an association between SDB and an elevated risk of cancer mortality in a population-based sample. If the relationship between SDB and cancer mortality is validated in further studies, the diagnosis and treatment of SDB in patients with cancer might be indicated to prolong survival," Dr. Nieto concluded. "Additional studies are needed to replicate our results and to examine the relationships between SBD, obesity, and cancer mortality."


'/>"/>

Contact: Nathaniel Dunford
ndunford@thoracic.org
212-315-8620
American Thoracic Society
Source:Eurekalert

Related medicine news :

1. Obstructive Sleep Apnea in Kids May Have Genetic Cause
2. Sleep HealthCenters to Sponsor North East Sleep Society 2010
3. America's Hidden Pandemic: 100 Million Suffer From Sleep Problems
4. Solutions for Sleep Problems: Harvard's Improving Sleep Special Health Report and New Sleep Apnea Video
5. Behavioral therapy improves sleep and lives of patients with pain
6. Sleep problems and sleepiness increase the risk of motor vehicle accidents in adolescents
7. Severe sleep apnea decreases frequency of nightmare recall
8. Severe Sleep Apnea Has Silver Lining
9. The role of sleep in brain development
10. Sleep More, Lose Weight – Sleeplessness Linked to Obesity
11. National Sleep Awareness Week(R) (March 7-13): How Are You Sleeping?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/24/2017)... Mass. (PRWEB) , ... January 24, 2017 , ... ... company to visualize, detect, and eliminate cyber threats in real-time, today announced a ... This partnership will enable customers to monitor, respond and protect their critical information ...
(Date:1/24/2017)... (PRWEB) , ... January 24, 2017 , ... Center ... 21st century leadership, has named Hector M. Chavez, Manager, Employee & Labor Relations at ... center - as its Hispanic Leader of the Month. City of Hope is committed ...
(Date:1/24/2017)... Santa Rosa, CA (PRWEB) , ... January 24, 2017 , ... ... rates is good news for everyone and particularly good news for prostate cancer patients: ... from the diagnosis. , According to the report the cancer death rate has dropped ...
(Date:1/24/2017)... ... January 24, 2017 , ... A yellow fever outbreak in Brazil ... month. Yellow fever is primarily spread through contact with infected mosquitos. The outbreak has ... to prevent its spread. , According to multiple health organizations, the best way to ...
(Date:1/24/2017)... ... January 24, 2017 , ... “Spiritual Vitamins: ... the connection with God. “Spiritual Vitamins: A Spiritual Energy Booster” is the creation ... Faith Publishing, Mathai Yohannan’s new book engages the mind and spirit in a ...
Breaking Medicine News(10 mins):
(Date:1/24/2017)... -- www.Financialbuzz.com - The cannabis market ... the United States as eight more states had ... 64, the California Cannabis Legalization Initiative, was passed by a ... 2016. This outcome means that individuals in California ... certain amount of cannabis for personal use. According to a ...
(Date:1/24/2017)... 2017   QR Pharma , Inc., a ... therapies for the treatment of Alzheimer,s, Parkinson,s and ... four world-class key opinion leaders to its Scientific ... Pharma,s previous roster of impressive advisors in order ... the development of the breakthrough mechanism of action ...
(Date:1/24/2017)... Mezzion has filed a suit for damages ... that Dr. Reddy,s committed fraud relating to Dr. Reddy,s ... (FDA) cGMP practices, and misrepresenting its compliance to Mezzion.  ... Mezzion that it was compliant with FDA regulations, and ... also states that Dr. Reddy,s misconduct was the sole ...
Breaking Medicine Technology: