Navigation Links
Sleep disordered breathing and obesity: Independent effects, causes
Date:1/23/2009

Sleep Apnea Linked to Insulin Resistance, Independent of Obesity

In a study that addressed the issue of insulin sensitivity with respect to sleep disordered breathing (SDB), Naresh Punjabi, M.D., Ph.D. sought to examine the relationship between SDB and insulin resistance using the best tools at his disposal to do so.

The results definitively link SDB to pre-diabetic changes in insulin production and glucose metabolism. It was published in the first issue for February of the American Journal of Respiratory and Critical Care Medicine, published by the American Thoracic Society.

"In the past researchers have used body mass index, or BMI, as a proxy measure for body fat, but we know this to be a variable and crude tool to assess the true percentage of body fat," said Dr. Punjabi. "In addition, previous studies have used surrogate measurements to assess the body's response to insulin without investigating the interaction that occurs between reduced insulin sensitivity and increased insulin production in the body."

To address the shortcomings of previous studies, Dr. Punjabi and colleagues used two tools in their investigation into the link between SDB and insulin resistance: dual-energy x-ray absorptiometry (DEXA), a highly precise technique for assessing body fat, and frequently sampled intravenous glucose tolerance test (FSIVGTT), which provides a detailed picture of the subject's insulin sensitivity over time, rather than a simple snapshot at a specific moment.

They recruited 118 subjects, 39 who had no SDB, and 79 who were newly diagnosed with SDB but who had not been treated. Each subject underwent a sleep study to assess their level of SDB, and then underwent a FSIVGGT to determine their glucose metabolism and insulin sensitivity/production the following day.

"Our major finding was that, as we suspected, SDB was strongly associated with a decrease in the three major metabolic pathways that the
'/>"/>

Contact: Keely Savoie
ksavoie@thoracic.org
212-315-8620
American Thoracic Society
Source:Eurekalert

Page: 1 2 3 4 5

Related medicine news :

1. Obama Pajama Party, Sleeper Hit at Inauguration
2. Sleep Apnea Seems to Wear Down the Brain
3. Doctors Urged to Screen Diabetics for Sleep Apnea
4. Welsh Laboratory Discovers Natural Antidote for Sleep Disturbance Caused by Cell Phones; Don't Disturb Me! Asphalia for Natural Sleep
5. Dr. Mitchell L. Petusevsky, M.D., F.C.C.P. Meets Growing Demand for the Treatment of Sleep and Pulmonary Disorders
6. Holiday Weight Gain May Contribute to Sleep Apnea Extra Pounds May Produce Severe Problems for Adults
7. Sleep Disorder Could Signal Neurological Disease
8. Proper Sleep May Help Clear Arteries
9. Cure for Sleep Deprivation and Weakened Immune Systems: Treadmill Desk
10. Later school start times may improve sleep in adolescents and decrease risk of auto accidents
11. Data mining of inpatient records reveals the disease pattern of obstructive sleep apnea
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/1/2014)... Online retailer Disposable Medical Express has ... guarantee on their inventory of Tranquility incontinence care products. ... pads along with other personal care products. , ... a line of incontinence products that you love,” a ... works for you, you shouldn't have to compromise because ...
(Date:8/1/2014)... Stress management can be difficult in this ... concentration and diminish rest and leisure time, stress can mount ... to find a way to manage stress in order to ... “Having a good sense of work-life balance is the key ... founding clinician of SF Custom Chiropractic. “Stress, left unchecked, can ...
(Date:7/31/2014)... Just in time for Washington’s unusually ... is featuring new summertime drink specials on their famed ... locations throughout the season. , A longtime ... customer-nominated Seattle’s best happy hour is well-known for its ... Union location’s 25th anniversary this summer, Duke is now ...
(Date:7/31/2014)... you have asthma, you may have an asthma action plan ... respond to changes and understand when symptoms are getting worse ... you,re doing well, yellow means your asthma has worsened and ... New guidelines are now available to help your allergist steer ... away from the red zone. , "Management of acute loss ...
(Date:7/31/2014)... The 2013 PolyU TSI hit a record ... in 2012. The index measures inbound tourists’ satisfaction ... into an overall index. The 2013 index indicates ... Hong Kong over time. , The index shows ... in Hong Kong are attractions (79.27) and transportation ...
Breaking Medicine News(10 mins):Health News:Disposable Medical Express Offering Low Price Guarantee On Tranquility Products 2Health News:SF Custom Chiropractic Celebrates National Relaxation Day and the Benefits of Massage Therapy for the Month of August 2Health News:Seattle Seafood Restaurant Lake Union Duke's Chowder House Celebrating its 25th Anniversary, Still a Best Outdoor Deck Spot to Sip Up Cocktails in Record-Breaking Heat. 2Health News:Seattle Seafood Restaurant Lake Union Duke's Chowder House Celebrating its 25th Anniversary, Still a Best Outdoor Deck Spot to Sip Up Cocktails in Record-Breaking Heat. 3Health News:PolyU Released Report On 2013 Tourist Satisfaction and Tourism Service Quality Indices to Boost Tourism Development 2Health News:PolyU Released Report On 2013 Tourist Satisfaction and Tourism Service Quality Indices to Boost Tourism Development 3
... -- Could injecting a gene into a patient with ... Physician-scientists are setting out to answer that question in ... severe heart failure. , NewYork-Presbyterian Hospital/Columbia University Medical ... City area where the therapy is currently available. , ...
... will develop training standards and guidelines to ensure ... keeps pace with growth ... To develop first-of-its-kind,guidelines and training standards for ... disease, the Society for,Cardiovascular Angiography and Interventions (SCAI) ...
... Plans to build a second state-of-the-art CCRC across ... MATTHEWS, N.C., June 18 ACTS Retirement-Life,Communities has ... parcel,located near the intersection of Fullwood Lane and ... to add approximately 350 independent,living apartments and single ...
... U.K. study suggests , , WEDNESDAY, June 18 (HealthDay News) ... of anticipating how people might behave during a psychotic ... University of Cambridge, found that patterns of normal brain ... , The researchers compared the brain activity of 15 ...
... in Nation,s 4th Leading Cancer Killer, BETHPAGE, ... Cancer Research, the largest private foundation dedicated,exclusively to ... Request For Proposals (RFP) to identify promising research ... deaths in the United,States., The Lustgarten Foundation,s ...
... the National ... Injury Prevention Program, WASHINGTON, June ... Safety for Seniors Act of 2008,and urges lawmakers to provide ... Center to fully implement this critical,fall prevention initiative., "Millions ...
Cached Medicine News:Health News:First gene therapy for heart failure offered at NewYork-Presbyterian/Columbia 2Health News:SCAI Creates New Council for Rising Interest in Interventional Therapies for Structural Heart Disease 2Health News:SCAI Creates New Council for Rising Interest in Interventional Therapies for Structural Heart Disease 3Health News:ACTS Retirement-Life Communities Signs Land Purchase Agreement on 48-Acre Site in Matthews, North Carolina 2Health News:Brain Activity May Predict Schizophrenia Behavior 2Health News:Lustgarten Foundation Announces 2009 Request for Proposals (RFP) 2Health News:Samarion Praises Congress for Passage of Safety for Seniors Act of 2008 2
(Date:7/31/2014)... -- Rock Creek Pharmaceuticals, Inc., (NASDAQ: RCPI ... of its lead molecule, Anatabine Citrate, in ... Clinical, The Translational Pharmaceutics Company, based in the ... early development programs. The Company expects to ... of the third quarter with the Medicines Healthcare products ...
(Date:7/31/2014)... 31, 2014 Touro University California,s College of ... as the recipient of a $150,000 grant by the ... University to increase research and classroom space on its ... for the study of health sciences, and will help ... and interests of our students," said Shelley Berkley ...
(Date:7/31/2014)... July 31, 2014 Catylix, Inc. ( ... ( Milpitas, California ) announced today ... and commercialize new fluorination products and related chemistry. ... benefited from the use of substituents that are ... with polarity to improve binding and bioavailability. Fluorinated ...
Breaking Medicine Technology:Rock Creek Pharmaceuticals Provides Update of its European Drug Development Regulatory Strategy and selects Quotient Clinical for its early development programs 2Rock Creek Pharmaceuticals Provides Update of its European Drug Development Regulatory Strategy and selects Quotient Clinical for its early development programs 3Rock Creek Pharmaceuticals Provides Update of its European Drug Development Regulatory Strategy and selects Quotient Clinical for its early development programs 4Touro University California Garners Grant From Long Foundation 2Catylix, Inc. and Aspira Scientific Announce Joint Venture to Commercialize New Fluorination Technologies 2
... mental retardation, birth defects, and autism spectrum and ... in New YorkMADISON, N.J., March 17 Quest ... world,s leading provider of diagnostic testing, information and ... genomic hybridization (aCGH) postnatal test is now available ...
... Inc. announced today that it has achieved proof ... Inhibiting Multiple Pathways) kinase platform by designing a ... of both the PI3K (Phosphoinositide-3-kinase) pathway and the ... SF2626 has demonstrated the ability to inhibit both ...
Cached Medicine Technology:Quest Diagnostics ClariSure(TM) Postnatal Molecular Test Receives Clinical Laboratory Approval from New York State 2Quest Diagnostics ClariSure(TM) Postnatal Molecular Test Receives Clinical Laboratory Approval from New York State 3Quest Diagnostics ClariSure(TM) Postnatal Molecular Test Receives Clinical Laboratory Approval from New York State 4Semafore Achieves a Preclinical Milestone with SF2626, a PI3K-MEK Dual Pathway Kinase Inhibitor 2
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: