Navigation Links
Sleep-deprived mice show connections among lack of shut-eye, diabetes, age
Date:12/11/2013

PHILADELPHIA Sleep, or the lack of it, seems to affect just about every aspect of human physiology. Yet, the molecular pathways through which sleep deprivation wreaks its detrimental effects on the body remain poorly understood. Although numerous studies have looked at the consequences of sleep deprivation on the brain, comparatively few have directly tested its effects on peripheral organs.

During sleep deprivation cells upregulate the UPR the unfolded protein response a process where misfolded proteins get refolded or degraded.

Five years ago, researchers at the Perelman School of Medicine, University of Pennsylvania, showed that the UPR is an adaptive response to stress induced by sleep deprivation and is impaired in the brains of old mice. Those findings suggested that inadequate sleep in the elderly, who normally experience sleep disturbances, could exacerbate an already-impaired protective response to protein misfolding that happens in aging cells. Protein misfolding and clumping is associated with many diseases such as Alzheimer's and Parkinson's, noted Nirinjini Naidoo, Ph.D., research associate professor in the Division of Sleep Medicine in that study.

Naidoo is also senior author of a follow-up study in Aging Cell this month that shows, for the first time, an effect of sleep deprivation on the UPR in peripheral tissue, in this case, the pancreas. They showed that stress in pancreatic cells due to sleep deprivation may contribute to the loss or dysfunction of these cells important to maintaining proper blood sugar levels, and that these functions may be exacerbated by normal aging.

"The combined effect of aging and sleep deprivation resulted in a loss of control of blood sugar reminiscent of pre-diabetes in mice," says Naidoo. "We hypothesize that older humans might be especially susceptible to the effects of sleep deprivation on the disruption of glucose homeostasis via cell stress."

Working w
'/>"/>

Contact: Karen Kreeger
karen.kreeger@uphs.upenn.edu
215-349-5658
University of Pennsylvania School of Medicine
Source:Eurekalert  

Page: 1 2 3

Related medicine news :

1. Healthy Brain Connections Help Maintain Intellect in Old Age
2. New method to find novel connections from gene to gene, drug to drug and between scientists
3. Brains Connections May Predict Intelligence: Study
4. Autism Researchers Surprised by Impaired Brain Connections
5. Attorney Charles Boyk Features Life Connections of Ohio in The Chuck Boyk Challenge
6. Surprising connections between our well-being and giving, getting, and gratitude
7. Brain Connections Differ in Children With Autism
8. Computer algorithms help find cancer connections
9. New and Expanded Guarantee Program Offered by Surrogacy Matching and Legal Services Firm Creative Family Connections
10. Social connections drive the upward spiral of positive emotions and health
11. New Studies Examining Positive Connections Between Diet Rich in Wild Blueberries and Better Brain Health
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Sleep-deprived mice show connections among lack of shut-eye, diabetes, age
(Date:9/18/2014)... Naples, Florida (PRWEB) September 18, 2014 Dr. ... in the nation, has expanded his services at Basile Plastic ... one of the most sought after treatments in the world ... pain or strain. , According to Dr. Basile, Coolsculpting ... do not wish to undergo a surgical procedure. He also ...
(Date:9/18/2014)... 18, 2014 The new BuildClean™ ... to contractors and homeowners alike as it eliminates ... the home, causes potential health issues, and makes ... the BuildClean system allows contractors to virtually eliminate ... other standard remodeling tasks. , BuildClean removes up ...
(Date:9/18/2014)... HealthDay Reporter WEDNESDAY, Sept. 17, 2014 ... post-traumatic stress disorder symptoms are almost three times more likely ... The findings don,t prove a direct link between ... it,s also possible that certain women are prone to food ... the research seems to add to existing evidence connecting PTSD ...
(Date:9/18/2014)... CA (PRWEB) September 18, 2014 A positive ... stress and improve your health. This year, at the Weekend ... to announce that adored LA radio talk show host Mother ... when living with diabetes. , The always-funny Jo Anne ... and is best known for her widely acclaimed talk show ...
(Date:9/18/2014)... (PRWEB) September 18, 2014 Finding the ... leaving many dieters feeling that their weight loss struggle ... specially trained in the science of fast weight loss, ... without negative side effects. In fact, a recent in-house ... lost an average of 20 pounds during the first ...
Breaking Medicine News(10 mins):Health News:Naples Plastic Surgeon Introduces Pain-free Fat Removal Technique 2Health News:Naples Plastic Surgeon Introduces Pain-free Fat Removal Technique 3Health News:New BuildClean™ System Brings Livability Back to Home Remodeling 2Health News:New BuildClean™ System Brings Livability Back to Home Remodeling 3Health News:New BuildClean™ System Brings Livability Back to Home Remodeling 4Health News:PTSD Link to Food Addiction Seen in Report 2Health News:PTSD Link to Food Addiction Seen in Report 3Health News:DiabetesSisters Showcases Radio Talk Show Host Mother Love at Weekend for Women Conference in Los Angeles 2Health News:Diet Doc Discloses the Results of a Recent In-House Survey Revealing an Average Loss of 20 Pounds Per Month with Their No Carb Diet Plans 2Health News:Diet Doc Discloses the Results of a Recent In-House Survey Revealing an Average Loss of 20 Pounds Per Month with Their No Carb Diet Plans 3
... who received Medicare coverage reported improvements in health, ... to a study in the December 26 issue ... those with cardiovascular disease or diabetes, experience worse ... Medicare beneficiaries after age 65 years than insured ...
... for youngsters can reduce risk of shoulder injury, physician ... Playing catch with your young pitcher months before baseball season ... rotator cuff injuries, according to doctors at Methodist Hospital in ... high pitch count and throwing curve balls -- increases the ...
... taking things as they come, expert says , MONDAY, Dec. ... and social stress, and memories of lost loved ones can ... lead to seasonal blues during the holidays, says an expert ... expect difficult relationships to improve just because it,s Christmas are ...
... weeks to a better body &,better health begins on January ... this amazing challenge begins on January 5th at,the ,New Vision ... life changing challenge is simple; it includes a $25,enrollment fee, ... looks at the health of the cells in the body ...
... Introduces Plan to Use Funding Surplus to Provide ... HARRISBURG, Pa., Dec. 24 Governor Edward G.,Rendell ... billing, but to postpone collection until March 31. ... coverage that the state,s,physicians, and many other health ...
... 24 /Xinhua-PRNewswire/ -- Chindex International,Inc. (Nasdaq: CHDX ... and products in the People,s Republic of China, ... the listing of its common stock on,the NASDAQ ... NASDAQ Capital,Market to the NASDAQ Global Market has ...
Cached Medicine News:Health News:Health improves for previously uninsured adults after receiving Medicare coverage 2Health News:Playing Catch in Winter Could Save Kids' Pitching Arms 2Health News:Realistic Expectations Help Ward Off Holiday Depression 2Health News:10 Weeks to a Better Body & Better Health With Dr. Ramsey's Health Challenge 2Health News:Governor Rendell Directs Insurance Commissioner to Delay Mcare Abatement Collection 2Health News:Governor Rendell Directs Insurance Commissioner to Delay Mcare Abatement Collection 3Health News:Governor Rendell Directs Insurance Commissioner to Delay Mcare Abatement Collection 4Health News:Governor Rendell Directs Insurance Commissioner to Delay Mcare Abatement Collection 5Health News:Chindex International, Inc. Announces Transfer to NASDAQ Global Market 2Health News:Chindex International, Inc. Announces Transfer to NASDAQ Global Market 3
(Date:9/18/2014)... 18, 2014  Spring Bank Pharmaceuticals, Inc., a ... treatment of RNA viruses, today announced a research ... for animal testing of the Company,s lead compound, ... "Special Pathogens," against which currently there are no ... Spring Bank,s proprietary Small Molecule Nucleic Acid ...
(Date:9/18/2014)... , Sept. 18, 2014  RXi ... a biotechnology company focused on discovering, developing ... medical needs using RNA-targeted technologies, today announced that ... Dr. Geert Cauwenbergh , will present ... America™ Conference on Wednesday, September 24, 2014 ...
(Date:9/17/2014)... -- DeepResearchReports.com adds "2014 Market Research Report on ... Research Report on Global and China Isothiocyanate Industry" ... Photo - http://photos.prnewswire.com/prnh/20140917/146748 ... (MMA) Industry" is a professional and in-depth research ... Global Methyl Methacrylate (MMA) market. The report introduces ...
Breaking Medicine Technology:Spring Bank Pharmaceuticals Announces NIH Collaboration for Testing of SB 9200 Against Multiple Viral Pathogens 2RXi Pharmaceuticals to Present at the 7th Annual BioPharm America Conference 2RXi Pharmaceuticals to Present at the 7th Annual BioPharm America Conference 3Methyl Methacrylate Market & Chinese Isothiocyanate Industry Trend Development 2Methyl Methacrylate Market & Chinese Isothiocyanate Industry Trend Development 3Methyl Methacrylate Market & Chinese Isothiocyanate Industry Trend Development 4Methyl Methacrylate Market & Chinese Isothiocyanate Industry Trend Development 5
... Spencer Inc. (NYSE: CSA ) announced today ... of $0.10 per common share payable on October 20, 2010 ... covers the third quarter of 2010.   ... Spencer Inc. (NYSE: CSA ) is a fully-integrated, ...
... Pharmaceutical Company (NYSE:  KVa/KVb) announced today that it has ... ("FDA") of the successful completion of an inspection of ... product to market.  Under the Company,s Consent Decree, successful ... facilities are expected to be required before K-V is ...
Cached Medicine Technology:Cogdell Spencer Inc. Declares Quarterly Dividend 2K-V Pharmaceutical Company Announces Completion of U.S. Food and Drug Administration Inspection and Approval to Return its First Product to Market 2K-V Pharmaceutical Company Announces Completion of U.S. Food and Drug Administration Inspection and Approval to Return its First Product to Market 3K-V Pharmaceutical Company Announces Completion of U.S. Food and Drug Administration Inspection and Approval to Return its First Product to Market 4K-V Pharmaceutical Company Announces Completion of U.S. Food and Drug Administration Inspection and Approval to Return its First Product to Market 5K-V Pharmaceutical Company Announces Completion of U.S. Food and Drug Administration Inspection and Approval to Return its First Product to Market 6K-V Pharmaceutical Company Announces Completion of U.S. Food and Drug Administration Inspection and Approval to Return its First Product to Market 7K-V Pharmaceutical Company Announces Completion of U.S. Food and Drug Administration Inspection and Approval to Return its First Product to Market 8
Hardy pituitary spoon, bayonet, malleable....
Cushing pituitary spoons, malleable copper, silver plated....
... is pouncing on the T.L.I.F. market as the ... of CFRP clinical history and the amazing success ... Leopard is sure to be king of the ... from 7-18 mm in height. The footprint is ...
... an Anterior Spinal Implant system. Material that ... of cortical bone. The result is an ... anterior column support, while optimizing the fusion ... Incorporates an anatomic design with 5 and ...
Medicine Products: