Navigation Links
Sleep apnea is associated with subclinical myocardial injury
Date:10/24/2013

Obstructive sleep apnea is known to be associated with an increased incidence of cardiovascular disease. Now a new study indicates that OSA is associated with subclinical myocardial injury, as indicated by increased high sensitivity troponin T (hs-TnT) levels. Elevated hs-TnT levels are predictive of both coronary heart disease (CHD) and heart failure (HF) in the general population. This is the first study to demonstrate an independent association between sleep apnea severity and this marker of early myocardial injury.

"Although OSA is associated with increased cardiovascular risk, a causal association has been hard to establish because of the association of OSA with other risk factors," said researcher Amil M. Shah, MD, MPH, of the Brigham and Women's Hospital in Boston. "In our study, we were able to demonstrate that greater OSA severity is independently associated with higher hs-TnT levels, suggesting a role for subclinical myocardial injury in the relationship between OSA and heart failure."

The findings were published online ahead of print publication in the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine.

The study included 1,645 middle-aged and older participants in both the Atherosclerosis Risk in Communities and the Sleep Health Study who were free of CHD and HF at baseline. All subjects underwent overnight home polysomnography. Median follow-up was 12.4 years. OSA severity was categorized as none, mild, moderate, or severe using the respiratory disturbance index.

Hs-TnT levels, but not N terminal pro B-type natriuretic peptide levels (a marker for increased ventricular wall stress), were significantly associated with OSA after adjustment for 17 potential confounders (p=0.02), including age, gender, body mass index, smoking status, hypertension, diabetes, alcohol intake, pulmonary function variables (FEV1 and FVC), COPD status, systolic blood pressure, total cholesterol, LDL cholesterol, HDL cholesterol, triglycerides, insulin level and estimated glomerular filtration rate (eGFR). In all OSA severity categories, hs-TnT was significantly related to the risk of death or incident heart failure, and this relationship was strongest in the severe OSA group.

Limitations of the study include its cross-sectional design, which precludes conclusions on causality, and a limited number of participants with severe OSA.

"Our results suggest a relationship between subclinical myocardial injury and the increased cardiovascular risk seen in patients with OSA," said Dr. Shah. "Monitoring of hs-TnT levels in these patients may have prognostic value, particularly in patients with severe OSA."


'/>"/>

Contact: Nathaniel Dunford
ndunford@thoracic.org
American Thoracic Society
Source:Eurekalert

Related medicine news :

1. “Pregnant? New Baby? Need Sleep!” is the Title of Dr. Richard Hansler’s Latest Book
2. SafeToSleep Infant Breathing Monitor Nominated for Fifth National Parenting Award of 2013
3. Sleep Apnea-Prone Truck Drivers Must Explore Treatment Options
4. Diet Doc Hormone Diets & Weight Loss Plans Offers New Diet Plans that Promote Safe and Rapid Weight Loss for a Good Night’s Sleep and Reduced Food Costs
5. The Australasian Academy of Dental Sleep Medicine (AustADSM) Provides Mini-Residency Programs for Post Graduates in the Dental Treatment of Snoring and Sleep Apnea
6. SleepBetter.org and Carpenter Co. Complete Historic Pillow-in-Space Launch
7. Calming fear during sleep
8. Introducing an Innovative New Pillow for Better Sleep and Better Back Pain Relief
9. SafeToSleep Expands International Distribution of Breakthrough Sleep and Breathing Baby Monitor
10. National Parenting Center Recognizes Lifenest® Sleep System™ With Seal of Approval
11. Sleep Apnea Endangers Safe Roads
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/30/2016)... ... 2016 , ... “Aging well is a challenge for all of us, but there are things we can do ... . “Research is showing more and more that there are simple, yet important steps that ... we age.” Top priorities Dr. Kohli’s recommends for her patients include;, , ...
(Date:4/29/2016)... ... April 29, 2016 , ... Since ... the national charitable foundation serving the footwear industry, has broken all previous participation ... than 130 companies across 23 states during the months of April and May, ...
(Date:4/29/2016)... ... April 29, 2016 , ... The American workforce ... stability, even security. Most importantly, employees are the single most important asset in ... workers so unhappy? , Just under half of American workers are emotionally checked ...
(Date:4/29/2016)... ... April 29, 2016 , ... A ... born with severe congenital diaphragmatic hernia have better survival rates if surgery is ... hernia (CDH)—a condition where the diaphragm fails to form completely, letting abdominal organs ...
(Date:4/29/2016)... ... April 29, 2016 , ... ... Celiac Association (CCA), is pleased to announce the launch of the GFCP ... articles, recipes, and more. The purpose of the GFCP Scoop site ...
Breaking Medicine News(10 mins):
(Date:4/27/2016)... 27, 2016   Zillion Group today ... technology platform, which specializes in live video consultation. ... digital products, Zillion enables companies to realize the ... to take control of their health. ... – including one-to-one, group and webcast scheduled or ...
(Date:4/27/2016)... , April 27, 2016 ... of the  "Global Anesthesia Disposables Market 2016-2020" ... http://photos.prnewswire.com/prnh/20160330/349511LOGO ) ,The global anesthesia disposables ... CAGR of 4.03% during the period 2016-2020.  ... major threat to patients, safety. Organizations like ...
(Date:4/27/2016)... April 27, 2016 At the ... launch of a Phase 2 clinical study of its ... patients undergoing cochlear implantation (CI) surgery. This large, placebo-controlled, ... Germany and France ... ear at the time of surgery. "Despite advances in ...
Breaking Medicine Technology: