Navigation Links
Sleep Disorder May Help Predict Parkinson's Decades Earlier
Date:7/28/2010

By Amanda Gardner
HealthDay Reporter

WEDNESDAY, July 28 (HealthDay News) -- A certain type of sleep disorder may be an early warning of Parkinson's disease and other neurological disorders, new research confirms.

Patients with REM sleep behavior disorder, a condition in which people violently act out their dreams during the rapid eye movement cycle of sleep, have been found to develop Parkinson's and related neurological disorders as much as a half century later.

The findings suggest that these neurological disorders may start developing much earlier than previously suspected.

Once researchers can identify which patients with REM sleep behavior disorder (RBD) will go on to develop a neurodegenerative disease -- something that is not yet possible -- they may be able to intervene earlier.

"It just makes sense that we're not going to really impact diseases like this unless we intervene early," said Dr. Bradley F. Boeve, senior author of a paper released online July 28 in advance of publication in the Aug. 10 print issue of Neurology.

"If you can intervene when the disease is still at the brain stem and not affecting some other critical structure in the brain, hopefully at the very least we can slow it down," he said.

Another expert, Dr. Michael Thorpy, agrees. "This is important for us understanding the progression of the disease because this RBD obviously precedes other clinical manifestations of Parkinson's by many years," said Thorpy, director of the Sleep-Wake Disorders Center at Montefiore Medical Center in New York City. "In the future, should we ever have something that can modify the disease process of Parkinson's, then very early diagnosis may be critical."

A connection between Parkinson's and RBD was first noticed a couple of decades ago by researchers at the Mayo Clinic, said Boeve, a professor of neurology at the Mayo Clinic in Rochester, Minn. Until now, the median interval noted between the two was about 10 years.

"Some people tell us that their wedding night -- that was the first time couples slept together back in those days" -- was the first indication of a problem, Boeve said. "Wives would report 'I got punched. I didn't know what I would be enduring for decades to come.'"

Boeve and his co-authors reviewed Mayo Clinic records to identify 27 patients who had RBD and went on to develop Parkinson's, dementia with Lewy bodies or multiple system atrophy, all neurodegenerative diseases, 15 or more years later.

Thirteen of the patients were diagnosed with dementia, another 13 with Parkinson's and one with multiple system atrophy.

Among the entire database of hundreds of patients (this included people with shorter intervals between the two diagnoses), only one with the sleep disorder had autopsy-confirmed Alzheimer's, Boeve said.

The average time elapsing between RBD and one of the other diseases was 25 years, the researchers found.

Eighty-nine percent of the patients in the sample were men, although it's not clear why, as neurological disorders affect both genders, noted the authors of an accompanying editorial.

Boeve cautions that "not everybody that acts out dreams at night has RBD." They may have another sleep disorder producing similar symptoms, he said.

And it's unlikely that everyone with RBD will go on to develop Parkinson's or a kindred disorder, if they live long enough, he said.

The new findings, while informative, aren't enough by themselves to make a difference in patients' lives, experts said.

Dr. Carlos Singer, professor of neurology at the University of Miami Miller School of Medicine, said clinicians won't be able to identify candidates for early intervention "unless we find another clue how to distinguish [those who do progress and those who don't] at an early stage."

More information

Visit the National Sleep Foundation for more on REM sleep behavior disorder.

SOURCES: Bradley F. Boeve, M.D., professor of neurology, Mayo Clinic, Rochester, Minn.; Carlos Singer, M.D., professor of neurology, University of Miami Miller School of Medicine, Miami; Michael Thorpy, M.D., director, Sleep-Wake Disorders Center, Montefiore Medical Center, Bronx, N.Y.; July 28, 2010, Neurology, online


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Obstructive Sleep Apnea in Kids May Have Genetic Cause
2. Sleep HealthCenters to Sponsor North East Sleep Society 2010
3. America's Hidden Pandemic: 100 Million Suffer From Sleep Problems
4. Solutions for Sleep Problems: Harvard's Improving Sleep Special Health Report and New Sleep Apnea Video
5. Behavioral therapy improves sleep and lives of patients with pain
6. Sleep problems and sleepiness increase the risk of motor vehicle accidents in adolescents
7. Severe sleep apnea decreases frequency of nightmare recall
8. Severe Sleep Apnea Has Silver Lining
9. The role of sleep in brain development
10. Sleep More, Lose Weight – Sleeplessness Linked to Obesity
11. National Sleep Awareness Week(R) (March 7-13): How Are You Sleeping?
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Sleep Disorder May Help Predict Parkinson's Decades Earlier
(Date:6/27/2016)... ... 27, 2016 , ... A revolution is underway. Brooklyn-based ... experience for the millions of people who require these medical transport services annually. ... through the use of technology. Now, SmartEMS has put forth an industry-changing app ...
(Date:6/26/2016)... (PRWEB) , ... June 27, 2016 , ... Quality metrics ... yet in many ways they remain in the eye of the beholder, according to ... a publication of The American Journal of Managed Care. For the full issue, ...
(Date:6/26/2016)... Aliso Viejo, California (PRWEB) , ... June 26, 2016 , ... ... for Final Cut Pro X. , "Film editors can give their videos a whole ... artistically," said Christina Austin - CEO of Pixel Film Studios. , ProSlice Levels ...
(Date:6/26/2016)... (PRWEB) , ... June 26, 2016 , ... Brent Kasmer, a legally blind and certified ... be personalized through a fitness app. The fitness app plans to fix the two major ... only offer a one size fits all type program , They don’t eliminate ...
(Date:6/25/2016)... ... June 25, 2016 , ... Experts from the American ... Annual Research Meeting June 26-28, 2016, at the Hynes Convention Center in Boston. ... including advance care planning, healthcare costs and patient and family engagement. , AIR ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)...   Bay Area Lyme Foundation , collaborating ... for Tick Borne Illness , Harvard Medical School ... Medicine, University of California, Berkeley, and the Veterans ... finalists of Lyme Innovation , the first ... scientists, clinicians, researchers, entrepreneurs, and investors from several ...
(Date:6/24/2016)... The Academy of Managed Care Pharmacy (AMCP) ... would allow biopharmaceutical companies to more easily share health ... and coverage decisions, a move that addresses the growing ... The recommendations address restrictions in the sharing of ... label, a prohibition that hinders decision makers from accessing ...
(Date:6/24/2016)... June 24, 2016 Research and Markets ... for Companion Diagnostic Tests" report to their offering. ... Companion Diagnostics The World Market for Companion ... medicine diagnostics. Market analysis in the report includes the following: ... (In Vitro Diagnostic Kits) by Region (N. America, EU, ROW), ...
Breaking Medicine Technology: