Navigation Links
Sleep Deprivation Might Lead to Alzheimer's
Date:9/24/2009

Research in mice suggests that suspect plaques build up during waking hours,,,,

THURSDAY, Sept. 24 (HealthDay News) -- If you're middle-aged, you might want to try a little harder to get a good night's sleep, now that new research suggests the right amount of slumber might keep Alzheimer's disease at bay.

The research was conducted in mice and is preliminary, and it may not apply to humans. Still, the possible link between sleep deprivation and Alzheimer's raises the prospect of possible treatments that target related pathways in the brain, explained study author Dr. David M. Holtzman, chairman of neurology at Washington University School of Medicine in St. Louis.

"This might be a way to delay or prevent the disease by doing something in middle life" rather than waiting until something goes wrong, Holtzman said.

The Alzheimer's Association estimates that as many as 5.3 million people in the United States have the disease, which is the country's seventh-leading cause of death. Alzheimer's disease is incurable, and although some treatments are available, they only relieve symptoms. In some cases, those symptoms include sleep problems.

Holtzman and his colleagues were not initially looking at sleep, but instead wanted to better understand how a protein clogs the brains of people with Alzheimer's. It's not clear how these clogs, known as plaques, and structures called "tangles" cause symptoms. But experts think it may have something to do with their disruption of how neurons communicate with each other.

The researchers developed a way to monitor the levels of the protein by the hour in both humans -- through a continual measurement of their spinal fluid via a catheter -- and mice. Their findings are reported online Sept. 24 in Science.

The researchers discovered that the level of the protein went up during waking hours and fell during sleep. Holtzman said that its levels may be related to brain activity, which is higher during waking hours.

In mice, the researchers found that sleep deprivation boosted the levels of the protein, which builds up in plaques.

If a person is awake for a long time, levels of the protein might build up, Holtzman said. This could play a role in middle age because Alzheimer's disease begins to clog the brain several years before symptoms become apparent.

Dr. Nikolaos Scarmeas, an associate professor of neurology at Columbia University Medical Center in New York City, said the findings are "very impressive, extremely valid and useful."

Researchers have linked sleep problems and Alzheimer's disease before, he said, but from the perspective of the sleep problems being a symptom of the illness and a result of aging. The idea that sleep deprivation might cause Alzheimer's deserves more attention, Scarmeas said.

Holtzman said that future research should investigate how processes in the brain can be manipulated with drugs so that people get more sleep and less brain clogging.

For now, though, his advice is short and simple: "Get enough sleep in middle age."

More information

The Alzheimer's Association has more about Alzheimer's disease.



SOURCES: David M. Holtzman, M.D., chairman, neurology, and associate director, Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis; Nikolaos Scarmeas, M.D., associate professor, neurology, Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Medical Center, New York City; Sept. 24, 2009, Science, online


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Time to Set Kids Back-to-School Sleep Clocks
2. AASM encourages those student-athletes at risk for developing osa to visit a sleep clinic
3. Sleepless Kids Are Troubled Kids
4. Jefferson specialists studying innovative surgery for effectively treating sleep apnea
5. Work time is the largest influence to the duration of a persons sleep
6. Passive smoking increases sleep disturbance among pregnant women
7. Minorities more likely to have sleep durations associated with increased mortality
8. Lack of sleep among new school-goers leads to behavioral, cognitive problems
9. Work Time Predicts Sleep Time
10. Nicotine in breast milk disrupts infants sleep patterns
11. Pain patients at risk for sleep apnea
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Sleep Deprivation Might Lead to Alzheimer's
(Date:5/3/2016)... ... 2016 , ... Healing Cancer in This Century is a Summit ... recovery and is offered by creator and visionary Carlos Caridad. Healing Cancer In ... considering medical and healing modalities of the fields of Integrative, Alternative, Energetic, Holistic ...
(Date:5/3/2016)... ... ... Calvary Hospital recently hosted a reception to mark a new music program ... Mary, Manning Walsh Home (MMW) in Manhattan. , During the school year, a ... once a week. The music brings a lot of joy to the patients, family ...
(Date:5/3/2016)... (PRWEB) , ... May 03, 2016 , ... ... a process that selects DNA or RNA from a random library of sequences ... be used as drugs or diagnostic agents. SELEX selection is commonly performed using ...
(Date:5/3/2016)... ... May 03, 2016 , ... Cosmetic surgeon Dr. Mark Youssef ... 2014, incorporating the injectable filler into his menu of services to give his patients ... than a year later, he’s still improving his approach to ensure he stays at ...
(Date:5/3/2016)... WORTH, Texas (PRWEB) , ... May 03, 2016 , ... ... of the signs of pet anxiety. "Pet owners often think anxiety only manifests ... sending stress signals in other ways, and there’s things that be done about it,” ...
Breaking Medicine News(10 mins):
(Date:4/29/2016)... , April 29, 2016 ... Life Sciences, Product Development Capabilities in ... Customer Base . Indegene ( ... announced the acquisition of Skura Corporation,s life science ... in adaptive sales enablement technology for life science ...
(Date:4/28/2016)... 28, 2016   Click here for supplemental ... (NYSE: DPLO), the nation,s largest independent specialty pharmacy, ... agreement to acquire Valley Campus Pharmacy, Inc., doing ... leading specialty pharmacy that provides individualized patient care, ... . In 2015, TNH generated approximately $400 million ...
(Date:4/28/2016)... Dr. ... und Stephen Schmidt werden Teil ... ein führender Anbieter cloudbasierter Softwarelösungen für den ... neue Führungskräfte zum Team Sicherheit und Pharmakovigilanz ... Erfahrungen mitbringen.  Dies wird die Geschäftseinheit Sicherheit ...
Breaking Medicine Technology: