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Sleep Deprivation May Disrupt Your Genes

By Randy Dotinga
HealthDay Reporter

MONDAY, Feb. 25 (HealthDay News) -- Far more than just leaving you yawning, a small amount of sleep deprivation disrupts the activity of genes, potentially affecting metabolism and other functions in the human body, a new study suggests.

It's not clear how your health may be affected by the genetic disruption if you don't get enough sleep. Still, the research raises the possibility that the effects of too little sleep could have long-lasting effects on your body.

"If people regularly restrict their sleep, it is possible that the disruption that we see . .. could have an impact over time that ultimately determines their health outcomes as they age in later life," said study co-author Simon Archer, who studies sleep at the University of Surrey, in England.

The study was published online Feb. 25 in the Proceedings of the National Academy of Sciences.

At issue is how a lack of enough sleep affects the human body. While it's obvious that people get tired when they don't sleep, scientists have only recently started to understand how sleep deprivation affects more than the brain, said Dr. Charles Czeisler, chief of the division of sleep medicine at Brigham and Women's Hospital, in Boston. Research has suggested that sleep is important all the way down to the level of cells, said Czeisler, who was not involved in the new study.

For the study, researchers recruited 26 volunteers who spent a week getting a normal amount of sleep (8.5 hours) and a week getting less than normal (5.7 hours). The participants were still able to enter periods of deep sleep.

The researchers then studied the genes of the participants in blood samples and found that numerous genes, including some related to metabolism, became less active.

So what does that mean for the body? "We have no idea," Archer said, "but these effects are not minor." They appear to be similar to those that separate normal from abnormal types of tissue in the body, he said.

Archer said the next step will be to investigate how a lack of sleep affects the body in the long term and to figure out whether some kinds of people are more vulnerable to sleep deprivation's negative effects on health.

For his part, Czeisler praised the study and said it raises the prospect of a blood test that will tell doctors if a patient's body is being affected because he or she isn't getting enough sleep. That's important because substances such as caffeine can hide the effects of lack of sleep so patients don't realize there's a problem, he said.

What about the possibility of a pill that mimics the effects of sleep so people don't have to bother getting some shut-eye in the first place? There's no evidence to support the idea of such a pill, Czeisler said, although there's ongoing research into how to improve the quality of sleep that people do manage to get.

More information

For more about sleep disorders, try the U.S. National Library of Medicine.

SOURCES: Simon Archer, reader in chronobiology, University of Surrey, United Kingdom; Charles A. Czeisler, Ph.D., M.D., chief, sleep medicine, Brigham and Women's Hospital, and professor and director, sleep medicine, Harvard Medical School, Boston; Feb. 25, 2013, Proceedings of the National Academy of Sciences, online

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