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Skin flaps deliver cancer-fighting therapy, ASPS study reveals
Date:5/8/2008

, according to the study.

Additionally, the serious side effects previously documented with systemic use of IL-12 were not found in the treated rats. The liver, lung and spleen remained normal throughout the study. The delivery technique through free flaps did not cause liver toxicity, whereas using IL-12 intravenously in humans has been shown to cause liver damage.

This could be a major advance for the delivery of a therapeutic agent to diseased parts of the body, said Dr. Gurtner. I can see this therapy being used for breast cancer, head and neck cancers, central nervous system malignancies, and somewhere down the line hemophilia, diabetes and infections.

The study authors concluded that as oncologic reconstructive surgery is a major component of plastic surgery, the delivery of a healing agent precisely to the region where cancer was and where local recurrences are most likely to occur, could add a new dimension to the reconstructive function of free flaps in oncologic and reconstructive plastic surgery.


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Contact: ASPS Media Relations
media@plasticsurgery.org
847-228-9900
American Society of Plastic Surgeons
Source:Eurekalert

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