Navigation Links
Skin color studies on tadpoles lead to cancer advance
Date:1/29/2009

The humble tadpole could provide the key to developing effective anti-skin cancer drugs, thanks to a groundbreaking discovery by researchers at the University of East Anglia (UEA).

The scientists have identified a compound which, when introduced into Xenopus Laevis tadpoles, blocks the movement of the pigment cells that give the tadpoles their distinctive markings and which develop into the familiar greenish-brown of the adult frog.

It is the uncontrolled movement and growth of pigment cells (melanophore) in both tadpoles and humans that causes a particularly dangerous form of skin cancer. By blocking the migration of these cells, the development and spread of cancerous tumours can potentially be prevented.

Published today in the Cell Press journal 'Chemistry & Biology', the findings are the culmination of several years' work by the UEA team. This unconventional study, which was initiated with funding from the UK Medical Research Council, identifies for the first time an effective new man-made MMP (metalloproteinase) inhibitor, known as 'NSC 84093'.

The work was led by the University of East Anglia, in partnership with the John Innes Centre (JIC) and Pfizer.

"This is an exciting advance with implications in the fight against cancer," said lead author Dr Grant Wheeler of UEA's School of Biological Sciences.

"The next step is to test the compound in other species and, in the longer term, embark on the development of new drugs to fight skin cancer in humans."

The species Xenopus Laevis (South African clawed frog) is more closely related to humans than one might expect. It only diverged from man 360 million years ago and has the same organs, molecules and physiology. This means that the same mechanisms are involved in causing cancer in both Xenopus tadpoles and humans.

Until the 1960s, Xenopus Laevis frogs were used as the main human pregnancy test. A woman's urine sample was injected into a live frog. If the urine contained the hCG (human chrionic gonadotropin) hormone, the frog would lay eggs within 24 hours, indicating that the woman was pregnant.


'/>"/>

Contact: Simon Dunford, Press Officer
s.dunford@uea.ac.uk
44-016-035-92203
University of East Anglia
Source:Eurekalert

Related medicine news :

1. African-Americans have worse prognosis at colorectal cancer diagnosis
2. Hormone Therapy May Cut Colorectal Cancer Risk
3. Land Rover Americas Polo Cup Team Plays in USPA World Snow Polo Championships, Aspen, Colorado
4. Colorado Among First States in Nation to Share Health Information Across Health Care Organizations
5. Journal of Nuclear Medicine premiers new, full-color design
6. CeloNova BioSciences Receives FDA Market Approval for Embozene(TM) Color-Advanced Microspheres Embolization Platform
7. Narrow-band imaging comparable to white light colonoscopy in differentiating colorectal polyps
8. Colorectal Cancer Racial Gap Still Growing
9. Screening for Colorectal Cancer Saves Lives
10. December 2008 Mayo Clinic Health Letter Highlights: Colorectal Screenings, Lighting Tips for Low Vision and Generic Medications
11. Economy Doesnt Dampen Colorados Giving Spirit According to Statewide Giving and Volunteering Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/8/2016)... ... December 08, 2016 , ... ... (WCRI) officially opened registration today for its 33rd Annual Issues & Research ... . , The theme of the conference is “Persistent Challenges and New Opportunities: ...
(Date:12/8/2016)... ... ... CURE Media Group, the nation’s leading digital and print media enterprise focused ... in efforts to combat lung cancer, announced CURE Media Group President Michael J. Hennessy, ... is honored to team up with Upstage Lung Cancer in order to make major ...
(Date:12/8/2016)... ... December 08, 2016 , ... ... its innovative Unified Instance Manager architecture, meeting the needs of multichannel growth ... optimizes the unattended auto-dialing system without agents, Presence Robodialer, provides greater operational ...
(Date:12/8/2016)... ... December 08, 2016 , ... ... as possible. With this in mind, SIGVARIS has created a new line of ... during bed rest and provide the benefits of graduated compression when transitioning from ...
(Date:12/8/2016)... ... December 08, 2016 , ... The Dan ... headquartered in Jefferson County, is announcing the launch of a charity drive to ... number of homeless women and children in Birmingham has grown steadily since the ...
Breaking Medicine News(10 mins):
(Date:12/8/2016)... -- Australia Ophthalmic Lasers Market Outlook to 2022 ... Outlook to 2022", provides key market data on the ... millions of US dollars, volume (in units) and average ... Lasers and YAG Lasers. The report also provides ... these market segements, and global corporate-level profiles of the ...
(Date:12/8/2016)... 2016 KEY FINDINGS The global ... 2017-2023. Various reasons for growth of the medical lifting ... of chronic diseases, high recovery cost of injuries and ... Medical lifting sling refers to an assistive device that ... slings connect to the lift and hold the patient. ...
(Date:12/8/2016)... Dec 8, 2016 Research and Markets has announced the ... to their offering. ... This report analyzes the worldwide markets for Endodontic Supplies in ... Canada , Japan , Europe , ... of World. Annual estimates and forecasts are provided for the period ...
Breaking Medicine Technology: