Navigation Links
Skin color studies on tadpoles lead to cancer advance
Date:1/29/2009

The humble tadpole could provide the key to developing effective anti-skin cancer drugs, thanks to a groundbreaking discovery by researchers at the University of East Anglia (UEA).

The scientists have identified a compound which, when introduced into Xenopus Laevis tadpoles, blocks the movement of the pigment cells that give the tadpoles their distinctive markings and which develop into the familiar greenish-brown of the adult frog.

It is the uncontrolled movement and growth of pigment cells (melanophore) in both tadpoles and humans that causes a particularly dangerous form of skin cancer. By blocking the migration of these cells, the development and spread of cancerous tumours can potentially be prevented.

Published today in the Cell Press journal 'Chemistry & Biology', the findings are the culmination of several years' work by the UEA team. This unconventional study, which was initiated with funding from the UK Medical Research Council, identifies for the first time an effective new man-made MMP (metalloproteinase) inhibitor, known as 'NSC 84093'.

The work was led by the University of East Anglia, in partnership with the John Innes Centre (JIC) and Pfizer.

"This is an exciting advance with implications in the fight against cancer," said lead author Dr Grant Wheeler of UEA's School of Biological Sciences.

"The next step is to test the compound in other species and, in the longer term, embark on the development of new drugs to fight skin cancer in humans."

The species Xenopus Laevis (South African clawed frog) is more closely related to humans than one might expect. It only diverged from man 360 million years ago and has the same organs, molecules and physiology. This means that the same mechanisms are involved in causing cancer in both Xenopus tadpoles and humans.

Until the 1960s, Xenopus Laevis frogs were used as the main human pregnancy test. A woman's urine sample was injected into a live frog. If the urine contained the hCG (human chrionic gonadotropin) hormone, the frog would lay eggs within 24 hours, indicating that the woman was pregnant.


'/>"/>

Contact: Simon Dunford, Press Officer
s.dunford@uea.ac.uk
44-016-035-92203
University of East Anglia
Source:Eurekalert

Related medicine news :

1. African-Americans have worse prognosis at colorectal cancer diagnosis
2. Hormone Therapy May Cut Colorectal Cancer Risk
3. Land Rover Americas Polo Cup Team Plays in USPA World Snow Polo Championships, Aspen, Colorado
4. Colorado Among First States in Nation to Share Health Information Across Health Care Organizations
5. Journal of Nuclear Medicine premiers new, full-color design
6. CeloNova BioSciences Receives FDA Market Approval for Embozene(TM) Color-Advanced Microspheres Embolization Platform
7. Narrow-band imaging comparable to white light colonoscopy in differentiating colorectal polyps
8. Colorectal Cancer Racial Gap Still Growing
9. Screening for Colorectal Cancer Saves Lives
10. December 2008 Mayo Clinic Health Letter Highlights: Colorectal Screenings, Lighting Tips for Low Vision and Generic Medications
11. Economy Doesnt Dampen Colorados Giving Spirit According to Statewide Giving and Volunteering Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... 26, 2016 , ... Pixel Film Studios Released ProSlice Levels, a Media Slicing ... their videos a whole new perspective by using the title layers in ProSlice ... , ProSlice Levels contains over 30 Different presets to choose from. FCPX ...
(Date:6/25/2016)... ... 25, 2016 , ... Austin residents seeking Mohs surgery services, can now turn ... to Dr. Russell Peckham for medical and surgical dermatology. , Dr. Dorsey brings specialization ... selective fellowship in Mohs Micrographic Surgery completed by Dr. Dorsey was under the direction ...
(Date:6/25/2016)... ... June 25, 2016 , ... ... recover from injury. Recently, he has implemented orthobiologic procedures as a method for ... is one of the first doctors to perform the treatment. Orthobiologics are substances ...
(Date:6/24/2016)... , ... June 24, 2016 , ... June 19, 2016 ... dangers associated with chronic pain and the benefits of holistic treatments, Serenity Recovery ... are suffering with Sickle Cell Disease. , Sickle Cell Disease (SCD) is a disorder ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... Comfort Keepers® ... American Cancer Society and the Road To Recovery® program to drive cancer patients to ... and other adults to ensure the highest quality of life and ongoing independence. ...
Breaking Medicine News(10 mins):
(Date:6/26/2016)... Ontario , June 27, 2016  VMS Rehab ... Company,s Board will take whatever measures required to build ... Company,s stock which is currently listed on the OTC ... Wexler, Company Chairman and CEO, "We are seeing an ... difficult to understand, not only by the Company, but ...
(Date:6/24/2016)... SOUTH SAN FRANCISCO, Calif. , June 24, ... GBT ), a biopharmaceutical company developing novel ... with significant unmet needs, today announced the closing ... 6,400,000 shares of common stock, at the public ... the shares in the offering were offered by ...
(Date:6/24/2016)... ALEXANDRIA, Va. , June 24, 2016 ... a set of recommendations that would allow ... information (HCEI) with entities that make formulary and coverage ... determine the "value" of new medicines. The ... that does not appear on the drug label, a ...
Breaking Medicine Technology: