Navigation Links
Skin color studies on tadpoles lead to cancer advance
Date:1/29/2009

The humble tadpole could provide the key to developing effective anti-skin cancer drugs, thanks to a groundbreaking discovery by researchers at the University of East Anglia (UEA).

The scientists have identified a compound which, when introduced into Xenopus Laevis tadpoles, blocks the movement of the pigment cells that give the tadpoles their distinctive markings and which develop into the familiar greenish-brown of the adult frog.

It is the uncontrolled movement and growth of pigment cells (melanophore) in both tadpoles and humans that causes a particularly dangerous form of skin cancer. By blocking the migration of these cells, the development and spread of cancerous tumours can potentially be prevented.

Published today in the Cell Press journal 'Chemistry & Biology', the findings are the culmination of several years' work by the UEA team. This unconventional study, which was initiated with funding from the UK Medical Research Council, identifies for the first time an effective new man-made MMP (metalloproteinase) inhibitor, known as 'NSC 84093'.

The work was led by the University of East Anglia, in partnership with the John Innes Centre (JIC) and Pfizer.

"This is an exciting advance with implications in the fight against cancer," said lead author Dr Grant Wheeler of UEA's School of Biological Sciences.

"The next step is to test the compound in other species and, in the longer term, embark on the development of new drugs to fight skin cancer in humans."

The species Xenopus Laevis (South African clawed frog) is more closely related to humans than one might expect. It only diverged from man 360 million years ago and has the same organs, molecules and physiology. This means that the same mechanisms are involved in causing cancer in both Xenopus tadpoles and humans.

Until the 1960s, Xenopus Laevis frogs were used as the main human pregnancy test. A woman's urine sample was injected into a live frog. If the urine contained the hCG (human chrionic gonadotropin) hormone, the frog would lay eggs within 24 hours, indicating that the woman was pregnant.


'/>"/>

Contact: Simon Dunford, Press Officer
s.dunford@uea.ac.uk
44-016-035-92203
University of East Anglia
Source:Eurekalert

Related medicine news :

1. African-Americans have worse prognosis at colorectal cancer diagnosis
2. Hormone Therapy May Cut Colorectal Cancer Risk
3. Land Rover Americas Polo Cup Team Plays in USPA World Snow Polo Championships, Aspen, Colorado
4. Colorado Among First States in Nation to Share Health Information Across Health Care Organizations
5. Journal of Nuclear Medicine premiers new, full-color design
6. CeloNova BioSciences Receives FDA Market Approval for Embozene(TM) Color-Advanced Microspheres Embolization Platform
7. Narrow-band imaging comparable to white light colonoscopy in differentiating colorectal polyps
8. Colorectal Cancer Racial Gap Still Growing
9. Screening for Colorectal Cancer Saves Lives
10. December 2008 Mayo Clinic Health Letter Highlights: Colorectal Screenings, Lighting Tips for Low Vision and Generic Medications
11. Economy Doesnt Dampen Colorados Giving Spirit According to Statewide Giving and Volunteering Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... ... in the greater Dallas, Miami, and Raleigh regions, is organizing an extended charity ... a rare and deadly chromosome abnormality. , After struggling since birth with several ...
(Date:10/13/2017)... ... October 13, 2017 , ... The American Board of Family ... next President and Chief Executive Officer, succeeding Dr. James C. Puffer upon his retirement. ... 1, 2018 until Dr. Puffer’s retirement at the end of 2018. Upon assuming the ...
(Date:10/13/2017)... QUEENS, N.Y (PRWEB) , ... October 13, 2017 , ... ... recently became a member of ElderCounsel, a national organization of elder law and special ... constantly changing laws and rules. It also provides a forum to network with elder ...
(Date:10/13/2017)... , ... October 13, 2017 , ... Ellevate Network, the ... business to advocate for action towards gender equality at their inaugural Summit in New ... the globe, and reached a social audience of over 3 million. To watch the ...
(Date:10/13/2017)... ... October 13, 2017 , ... ... Software Development, has been awarded a contract by the Center for Medicare and ... aims to accelerate the enterprise use of Agile methodologies in a consistent and ...
Breaking Medicine News(10 mins):
(Date:10/12/2017)... AVACEN Medical , Inc. (AVACEN) announced that Frost & ... Innovation Award for Its fibromyalgia pain management device. The ... market research by Frost & Sullivan,s industry experts. ... product, the AVACEN 100, offers a safe and effective solution ... ...
(Date:10/11/2017)... PARK, Calif. , Oct. 11, 2017  BioPharmX ... national scientific team that developed an innovative way to ... quantity of the delivery of new drugs. ... 2017 Fall Clinical Dermatology Conference will show how researchers ... General Hospital, Harvard Medical School used a suite of ...
(Date:10/11/2017)... -- Hill-Rom Holdings, Inc. ("Hill-Rom") (NYSE: HRC), today provided an ... Puerto Rico , where the company ... Following a comprehensive onsite assessment, ... damage, temporary loss of power and minimal water damage ... operations have resumed, and the company expects to return ...
Breaking Medicine Technology: