Navigation Links
Skin cell response to environmental stimuli like viruses may predict type 1 diabetes

(Boston)--Type 1 diabetes is a genetically-driven autoimmune disease of pancreatic beta-cells, whose origins remain unknown. Researchers at the Boston Medical Center (BMC) and Boston University School of Medicine (BUSM) discovered that skin cells from patients with type 1 diabetes display abnormal activity triggered by immune response mechanisms to environmental stimuli like a viral infection. These findings currently appear online in PLoS One.

They found that these cells acquire elevated levels of calcium when exposed to either cytokines or fat. In humans, cytokines or cell signalling molecules essential to the body's immune response, increase with the onset of infection as does an excess of fatty acids when people are sick and stop eating, a common occurrence in children when they get viruses.

"This is significant as it is known that a viral illness usually precedes the development of type 1 diabetes in children but no one knows why it should be related," says Barbara Corkey, PhD, Zoltan Kohn Professor of Medicine at BUSM and vice chair for Research in the Obesity Research Center at BMC. "Our findings that diabetic cells have a different sensitivity as indicated by higher levels of calcium to an environmental event such as a virus, may help to explain why the onset of type 1 diabetes might be triggered by an environmental stimulus as well as a genetic predisposition."

In fact, their data showed that skin cells from relatives of people with type 1 diabetes who are not afflicted with type 1 diabetes themselves display an intermediate calcium response to circulating signaling molecules. These data suggest that a unique environmental stimulus may interact with a genetic trait to initiate diabetes.

"Determination of this trait before development of diabetes could help to identify susceptible individuals prior to disease onset," adds Corkey.


Contact: Gina DiGravio
Boston University Medical Center

Page: 1

Related medicine news :

1. Does the bodys immune response to viral vector delivery systems affect the safety or efficacy of gene therapy?
2. Clinical waste may prove valuable for monitoring treatment response in ovarian cancer
3. U.S. Employers Adding Medical Travel Benefits at an Increased Rate in Response to Rising Healthcare Costs
4. Active Smoking Can Worsen Response to Treatment in Patients With Metastatic Kidney Cancer
5. Circulating tumor cells in blood can predict a patients response to chemotherapy
6. Cardiovascular Institute: Unfolded protein response contributes to sudden death in heart failure
7. Atlanta Drug Rehab Announces Program in Response to National Report on Illicit Drug Use
8. Study identifies protein essential for immune recognition, response to viral infection
9. Study Funded by National Foundation for Cancer Research Reveals Imaging Studies May Predict Tumor Response to Anti-Angiogenic Drugs
10. Forbes Living Joins the Direct Response Marketing Alliance
11. Oxygen levels in tumors affect response to treatment
Post Your Comments:
(Date:11/30/2015)... ... 2015 , ... The recently published 32nd Annual Report of ... that in 2014, someone called a poison center about every 11 seconds. America’s ... human exposure cases. , The American Association of Poison Control Centers (AAPCC) maintains ...
(Date:11/30/2015)... ... November 30, 2015 , ... The Foundation for Breast ... and prevention—is joining forces with the award-winning creator and writer of Downton Abbey ... 7, 2015 at the Union League of Philadelphia. , The benefit, titled ...
(Date:11/30/2015)... , ... November 30, 2015 , ... ... magazine, quoted Michael Hansen, Ph.D., a senior scientist at Consumer Reports as supporting ... so for a child’s exposure limits. , The original Nov 2015 CR story ...
(Date:11/30/2015)... ... November 30, 2015 , ... An inventor from Charlottesville, Va., is concerned about ... baby had high blood pressure due to loud noises," she said, "so I decided ... noise pollution as well as radio waves and microwaves." , The baby BABY MUFF ...
(Date:11/30/2015)... CHICAGO (PRWEB) , ... November ... ... introduced two new additions to its industry-leading suite of automated breast density ... of North America (RSNA) meeting, November 29-December 4, 2015 (South Hall booth ...
Breaking Medicine News(10 mins):
(Date:11/30/2015)... VIEW, Calif. , Nov. 30, 2015 ... been the norm in U.S. medical imaging ... The increasingly popular accountable care payer-provider contracts ... models and, in their wake, alter provider-vendor ... quality-based payments will push forward new purchasing ...
(Date:11/30/2015)... and SAN DIEGO , ... Pharmaceuticals, Inc. (NASDAQ: ARNA ) today announced that ... for filing the New Drug Application (NDA) for an ... release formulation will offer patients a chronic weight management ... ® ) is currently approved as an adjunct to ...
(Date:11/30/2015)... and ST. LOUIS , Nov. 30, ... ESRX ) today announced an early renewal of ... began in 1999, will now extend through at least ... After evaluating pharmacy benefit manager capabilities during a ... Scripts continues to offer the best health plan integration ...
Breaking Medicine Technology: