Navigation Links
Skin cell response to environmental stimuli like viruses may predict type 1 diabetes
Date:1/28/2014

(Boston)--Type 1 diabetes is a genetically-driven autoimmune disease of pancreatic beta-cells, whose origins remain unknown. Researchers at the Boston Medical Center (BMC) and Boston University School of Medicine (BUSM) discovered that skin cells from patients with type 1 diabetes display abnormal activity triggered by immune response mechanisms to environmental stimuli like a viral infection. These findings currently appear online in PLoS One.

They found that these cells acquire elevated levels of calcium when exposed to either cytokines or fat. In humans, cytokines or cell signalling molecules essential to the body's immune response, increase with the onset of infection as does an excess of fatty acids when people are sick and stop eating, a common occurrence in children when they get viruses.

"This is significant as it is known that a viral illness usually precedes the development of type 1 diabetes in children but no one knows why it should be related," says Barbara Corkey, PhD, Zoltan Kohn Professor of Medicine at BUSM and vice chair for Research in the Obesity Research Center at BMC. "Our findings that diabetic cells have a different sensitivity as indicated by higher levels of calcium to an environmental event such as a virus, may help to explain why the onset of type 1 diabetes might be triggered by an environmental stimulus as well as a genetic predisposition."

In fact, their data showed that skin cells from relatives of people with type 1 diabetes who are not afflicted with type 1 diabetes themselves display an intermediate calcium response to circulating signaling molecules. These data suggest that a unique environmental stimulus may interact with a genetic trait to initiate diabetes.

"Determination of this trait before development of diabetes could help to identify susceptible individuals prior to disease onset," adds Corkey.


'/>"/>

Contact: Gina DiGravio
gina.digravio@bmc.org
617-638-8480
Boston University Medical Center
Source:Eurekalert

Page: 1

Related medicine news :

1. Does the bodys immune response to viral vector delivery systems affect the safety or efficacy of gene therapy?
2. Clinical waste may prove valuable for monitoring treatment response in ovarian cancer
3. U.S. Employers Adding Medical Travel Benefits at an Increased Rate in Response to Rising Healthcare Costs
4. Active Smoking Can Worsen Response to Treatment in Patients With Metastatic Kidney Cancer
5. Circulating tumor cells in blood can predict a patients response to chemotherapy
6. Cardiovascular Institute: Unfolded protein response contributes to sudden death in heart failure
7. Atlanta Drug Rehab Announces Program in Response to National Report on Illicit Drug Use
8. Study identifies protein essential for immune recognition, response to viral infection
9. Study Funded by National Foundation for Cancer Research Reveals Imaging Studies May Predict Tumor Response to Anti-Angiogenic Drugs
10. Forbes Living Joins the Direct Response Marketing Alliance
11. Oxygen levels in tumors affect response to treatment
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/20/2014)... OH (PRWEB) October 20, 2014 Women’s ... Specialists in Obstetrics & Gynecology of Columbus, Inc., A ... women’s healthcare services to more than 100,000 patients annually. ... though all ages and stages of a women’s life. ... office locations in Westerville and Dublin. , Dr. ...
(Date:10/20/2014)... hc1.com today announced the launch ... that enables healthcare organizations of all sizes to ... relationship management (“CRM”) solution. , Designed from the ... the healthcare industry, the hc1 Healthcare Relationship Cloud™ ... by combining healthcare CRM, HIPAA-compliant collaboration, and real-time ...
(Date:10/20/2014)... CA (PRWEB) October 20, 2014 JZ ... expertise, nutritional coaching, corporate wellness programming, authorship, international lecturing ... is excited to announce the release of the JZ ... After many years of coaching thousands of individuals on ... tracking app that does not require calorie counting or ...
(Date:10/20/2014)... Principle Business Enterprises, a family owned ... top-of-the-line absorbent products. The company has recently made ... brand, Tranquility® Premium Protection absorbent products. The company ... its packaging a new look, and is currently working ... the public. , The new website, developed with Thread ...
(Date:10/20/2014)... 20, 2014 Myoderm ... Assistant Director of their CentralSource service. ... the innovative turnkey drug sourcing, distribution, and management ... over 12 years of industry experience, in both ... the peak of their international success to help ...
Breaking Medicine News(10 mins):Health News:OhioHealth Welcomes New Women’s Health Specialist to MaternOhio Specialists in Obstetrics & Gynecology of Columbus, Inc. 2Health News:OhioHealth Welcomes New Women’s Health Specialist to MaternOhio Specialists in Obstetrics & Gynecology of Columbus, Inc. 3Health News:Healthcare Relationship Management (HRM) Leader hc1.com® Launches hc1® Quick Start™ 2Health News:JZ Fitness Nutrition App Launches on iTunes 2Health News:JZ Fitness Nutrition App Launches on iTunes 3Health News:Tranquility® Premium Protection Incontinence Products Releases New Logo and Website 2Health News:Myoderm Hires Matthew Voicheck to Lead Turnkey Drug Sourcing Service 2
... , , CHICAGO, Sept. ... by House Majority Leader Steny Hoyer (D-MD) - for recognizing the ... the overall health care reform bill currently under consideration. Over ... Democrats and Republicans across the country talking with constituents at town ...
... , , , ... Supermarkets are helping customers stay healthy and well by once ... period will start September 17 and run through November 1 ... doctor-administered vaccines. , , (Logo: http://www.newscom.com/cgi-bin/prnh/20030421/STATERLOGO ...
... , , , JACKSONVILLE, ... taking place Friday, Sept. 11, 2009, Wounded Warrior Project (WWP) and ... revenues generated from global trades made on that day. , , ... was created while Cantor Fitzgerald rebuilt following the World Trade Center attacks ...
... , , FARMINGDALE, N.Y., ... a developer of minimally invasive ultrasonic medical device technology, which ... worldwide for other acute health conditions, today announced the restructuring ... business units have been created; one for sales and service ...
... COLO Research published in the September 2009 issue of ... an individual,s quality of life prior to treatment can help ... cell lung cancer (NSCLC). For those with advanced stage ... months, with approximately one-third of patients surviving past the one ...
... are developing computer models to comb through thousands of ... claims data to automatically classify them based on specific ... the most important causes of injuries so that efforts ... in society," said Mark Lehto, an associate professor in ...
Cached Medicine News:Health News:Statement from the American College of Surgeons Regarding Growing Democrat Support for Medical Liability Reform to be Included in Health Care Reform 2Health News:Stater Bros. Helps Customers Fight the Flu 2Health News:Wounded Warrior Project to Participate in BGC Partners Annual Charity Day 2Health News:Misonix Restructures and Expands Sales Organization in Europe 2Health News:Misonix Restructures and Expands Sales Organization in Europe 3Health News:Misonix Restructures and Expands Sales Organization in Europe 4Health News:New computer models aim to classify, help reduce injury accidents 2
(Date:10/17/2014)... The following is being released by ... The Green Park Collaborative (GPC) will bring together ... medical device and pharmaceutical companies, as well as ... 2015 at its first ever workshop on the ... Participants will discuss study designs to evaluate weight ...
(Date:10/17/2014)... NORWALK, Conn. , Oct. 17, 2014  UBM ... leading online community for endocrinologists and other clinicians who ... offers comprehensive coverage on effective use of insulin ... will eventually require insulin replacement therapy – ... up for the progressive decline in the function of ...
(Date:10/17/2014)... 2014  Ameritox SM , the nation,s leader in ... Thomas Smith , M.D., as Chief Medical Officer. In ... scientific resources for healthcare providers, patients and managed care ... at a variety of healthcare companies that have provided ... and behavioral health sides of Ameritox,s business. He most ...
Breaking Medicine Technology:Green Park Collaborative to Discuss Comparative Effectiveness and Value of Weight Loss Treatments 2Endocrinology Network Features Special Coverage on Effective Use of Insulin 2Endocrinology Network Features Special Coverage on Effective Use of Insulin 3Ameritox Appoints New Chief Medical Officer 2
... Generex Biotechnology Corporation ( www.generex.com ) (OTCBB: ... President & Chief Executive Officer, and Dr. Eric ... Antigen Express, Inc. ( www.antigenexpress.com ) will make ... 13th Annual Healthcare Conference.  The presentation will take ...
... CITY, Calif., Sept. 7, 2011 Codexis, Inc. ... the company will be participating in the following ... ConferenceDate: Thursday, September 15, 2011 (Company presentation)Time: 8:00 ... of Financial Planning & Analysis A webcast and ...
Cached Medicine Technology:Generex to Present at the Rodman & Renshaw 13th Annual Healthcare Conference 2Generex to Present at the Rodman & Renshaw 13th Annual Healthcare Conference 3
ENA Screen EIA Auto-Immune Markers 012-MDKES1 Extractable Nuclear Antigens...
Anti-PR3 EIA Auto-Immune Markers 013-PR3-48 Proteinase...
... can be viewed immediately, making procedures more efficient. ... the images are digital, they can be used ... electronic filing. The CR-DGi combines the power ... use. It's the latest advance from Canon, the ...
...
Medicine Products: