Navigation Links
Skin cell defect is surprising allergy trigger
Date:8/26/2013

CHICAGO --- In a new study published in Nature Genetics, Northwestern Medicine and Tel Aviv University scientists have found that a structural defect in skin cells can contribute to allergy development, including skin and food allergies, traditionally thought primarily to be a dysfunction of the immune system.

The finding is related to the team's identification of a new rare genetic disease, called "severe dermatitis, multiple allergies, and metabolic wasting," or SAM, caused by mutations in the molecule desmoglein 1.

"Desmoglein 1 is best understood as the 'glue' that holds the outer layer of human skin together," said Kathleen Green, Joseph L. Mayberry, Sr., Professor of Pathology and Toxicology at Northwestern University Feinberg School of Medicine. "Historically, the molecule was mainly believed to have a structural role: this adhesion between cells contributes to the physical barrier that regulates water loss and also acts as the body's major defense against environmental elements. But there are a large number of molecules that form this barrier, distributed in a highly-patterned manner, prompting our team to hypothesize that they do more than just mediate adhesion."

Green's group at Northwestern worked with an international team that analyzed clinical data from two families, combined with genetic analysis including next-generation DNA sequencing and light and electron microscopy, among other techniques. They found that when desmoglein 1 does not properly function or does not exist, the resulting barrier disruption can affect the immune response, and consequences can be severe.

"This work is also significant because it suggests that in addition to impairing the physical barrier, loss of desmoglein 1 may more directly regulate expression of genes that control the immune response and contribute to allergy," says Green. "Conceptually, it allows us to build on previous studies and make conclusions about the import
'/>"/>

Contact: Marla Paul
marla-paul@northwestern.edu
312-503-8928
Northwestern University
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Updated SSRI Birth Defects Lawsuits Allegations: Resource4thePeople Reports Cases Continue to Be Filed as Key Hearing Set in Consolidated Federal Litigation
2. Certain major birth defects associated with moderately increased cancer risk in children
3. Auto Accident Lawyers Release New Infographic about the Dangers of Defective Car Parts
4. New Lawsuit on Hip Replacement Defects: Now, AttorneyOne Can Provide Advice
5. Injury Law Firm Releases New Informational Graphic on the Alleged Birth Defect Risks of Dangers of Topamax
6. Skechers Lawsuit Filed on Behalf of New Mexico Woman Alleges that the Defective Design of Shape-Ups Caused Her Severe Arm and Knee Injuries, Reports Wright & Schulte
7. Cerebral Palsy and Medical Malpractice Lawsuit Allegations Update: Resource4thePeople Reports New Study Finds Cerebral Palsy, other Birth Defects Risk Increase with Assisted Conception
8. Pregnant Women Who Use Nasal Decongestants During the First Trimester May Increase Their Babies’ Risks of Birth Defects; Parker Waichman LLP Is Evaluating Legal Claims
9. Florida Man Says Stryker’s Rejuvenate Hip Implant is Defective, Causing him Serious Injuries, Need for Revision Surgery, Alleges Lawsuit Filed by Parker Waichman LLP
10. Manufacturers Failed to Warn About Defective Transvaginal Mesh Devices, Parker Waichman LLP Alleges in Lawsuit
11. Two Skechers Lawsuits Filed by Wright & Schulte Contends The Plaintiffs Suffered Severe Arm Injuries Due to the Alleged Defective Design of Shape-Ups
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2014)... Randy Dotinga HealthDay Reporter ... parasite that causes malaria is growing increasingly resistant to the ... reports. But several new drugs are in development, and at ... against this global killer. "Although there has been considerable ... against malaria is far from won, and there is still ...
(Date:7/31/2014)... 31, 2014 ReputationChief.Com, a well-recognized ... online reputation management service named ‘Remove Pissed Consumer’. ... organizations get rid of Pissed Consumer Complaints. , ... extensive research. ReputationChief.Com management assigned the responsibility to ... who are struggling in their social or professional ...
(Date:7/31/2014)... July 31, 2014 -- A new study by researchers ... a peptide called caerulein can convert existing cells in ... diabetes-insulin-producing beta cells. The study, published online July 31 ... new approach to treating the estimated 3 million people ... with type 1 diabetes. , "We have found a ...
(Date:7/31/2014)... CA (PRWEB) July 31, 2014 ... healthcare providers, strives in maintaining the highest standards ... That is why Healthpointe is offering Occupational ... surrounding employers, employees and patients. They also accept ... carriers. , Healthpointe’s Occupational Medicine services include, but ...
(Date:7/31/2014)... July 31, 2014 Dallas Fit Body ... Dallas, Texas to 3821 Ross Avenue, also in Dallas, in ... and potential members to burn fat and get in great ... move because he believes that the new space will help ... fitness results they want as well as accommodate new members ...
Breaking Medicine News(10 mins):Health News:Malaria Growing Resistant to Drugs Used to Fight It 2Health News:Malaria Growing Resistant to Drugs Used to Fight It 3Health News:ReputationChief.Com Announces a New Online Reputation Management Service 2Health News:A new way to generate insulin-producing cells in Type 1 diabetes 2Health News:Occupational Medicine Services Available at Healthpointe’s Perris Facility 2Health News:Dallas Fit Body Boot Camp Moves to New Location, Announces Grand Opening Set for Saturday August 9th 2
... Mom,s touch and diet Claire-Dominique Walker, PhD, ... The quality and quantity of maternal milk and maternal-infant ... according to recent research published in Developmental Psychobiology ... early in life can shape the physiology and behaviour ...
... N.C. A multidisciplinary team of University of North Carolina ... grant to develop computer models that will allow physicians to ... airway problems. The three co-principal investigators of the ... Stephanie Davis, MD, Chief of Pediatric Pulmonology in the School ...
... , THURSDAY, Feb. 3 (HealthDay News) -- ... and their doctors better understand the condition, a new ... a personal digital assistant (PDA) device. The patients used ... and other issues three times a day for 30 ...
... ANGELES (Feb. 2, 2011) A team of scientists from ... million grant from the California Institute for Regenerative Medicine ... discoveries for specific diseases. Additionally, another team ... million grant with a medical technology company aiming to develop ...
... HealthDay Reporter , WEDNESDAY, Feb. 2 (HealthDay News) -- ... increasingly common intestinal infection Clostridium difficile , which ... recurrence far better than currently used medications. Researchers ... drug often prescribed to C. difficile patients. ...
... By Maureen Salamon HealthDay Reporter , ... have devised a process to create ready-made, easily stored ... undergoing heart surgery or kidney dialysis. Using donor ... spent more than five years engineering the "off-the-shelf" blood ...
Cached Medicine News:Health News:Brains need love, too 2Health News:UNC researchers developing computer models for pediatric airway problems 2Health News:Cedars-Sinai research team awarded $1.9 million from CIRM to develop new tools and technologies 2Health News:Cedars-Sinai research team awarded $1.9 million from CIRM to develop new tools and technologies 3Health News:New Antibiotic Helps Prevent Recurrence of Dangerous Gut Infection 2Health News:New Antibiotic Helps Prevent Recurrence of Dangerous Gut Infection 3Health News:Researchers Craft Blood Vessels for Heart, Kidney Patients 2Health News:Researchers Craft Blood Vessels for Heart, Kidney Patients 3
(Date:7/31/2014)... Orexigen® Therapeutics, Inc. (Nasdaq: OREX ... 2014, on Thursday, August 7, 2014 before markets open. ... and conference call at 8:00 a.m. Eastern time (5:00 ... the call and webcast to discuss financial results and ... by calling (800) 708-4540 (domestic) or (847) 619-6397 (international), ...
(Date:7/31/2014)... Cipla Europe NV ("Cipla") ... entered into a commercial collaboration, covering the territory ... countries, for BioQuiddity,s OneDose ReadyfusOR™ in regional anesthetic ... launch the CE Marked OneDose ReadyfusOR pre-filled with ... market late this year. The ready-to-use infusion systems ...
(Date:7/31/2014)... England , July 31, 2014 ... today announced that its subsidiary, Molecular Profiles Ltd., ... will support pharmaceutical and biotech drug developers during ... pharmaceutical development services will be supported by XenoGesis, ... to give clients a smarter route into formulation ...
Breaking Medicine Technology:Orexigen Therapeutics to Host Second Quarter 2014 Financial Results Conference Call and Webcast 2Cipla and BioQuiddity Announce EU Commercial Partnership for OneDose-ReadyfusOR for Post-Surgical Pain Management 2Cipla and BioQuiddity Announce EU Commercial Partnership for OneDose-ReadyfusOR for Post-Surgical Pain Management 3Columbia Laboratories' Subsidiary, Molecular Profiles, Strikes Alliance With Xenogesis 2Columbia Laboratories' Subsidiary, Molecular Profiles, Strikes Alliance With Xenogesis 3
... Reportlinker.com announces that a new market research report is available in its catalogue: ... Stakeholder Opinions: Vaccines in emerging markets (Latin ... , , ... Introduction , ...
... WEST WINDSOR, N.J. , July 7 ITelagen, ... announced that it was selected by Zweena, LLC of West ... record application. ITelagen, which was selected for its expertise in EHR ... this innovative solution. , , ...
Cached Medicine Technology:Stakeholder Opinions: Vaccines in emerging markets (Latin America) - Opportunities in Brazil, Mexico and Argentina 2Stakeholder Opinions: Vaccines in emerging markets (Latin America) - Opportunities in Brazil, Mexico and Argentina 3Stakeholder Opinions: Vaccines in emerging markets (Latin America) - Opportunities in Brazil, Mexico and Argentina 4Stakeholder Opinions: Vaccines in emerging markets (Latin America) - Opportunities in Brazil, Mexico and Argentina 5Stakeholder Opinions: Vaccines in emerging markets (Latin America) - Opportunities in Brazil, Mexico and Argentina 6Stakeholder Opinions: Vaccines in emerging markets (Latin America) - Opportunities in Brazil, Mexico and Argentina 7Stakeholder Opinions: Vaccines in emerging markets (Latin America) - Opportunities in Brazil, Mexico and Argentina 8Stakeholder Opinions: Vaccines in emerging markets (Latin America) - Opportunities in Brazil, Mexico and Argentina 9Stakeholder Opinions: Vaccines in emerging markets (Latin America) - Opportunities in Brazil, Mexico and Argentina 10Stakeholder Opinions: Vaccines in emerging markets (Latin America) - Opportunities in Brazil, Mexico and Argentina 11Stakeholder Opinions: Vaccines in emerging markets (Latin America) - Opportunities in Brazil, Mexico and Argentina 12Stakeholder Opinions: Vaccines in emerging markets (Latin America) - Opportunities in Brazil, Mexico and Argentina 13Stakeholder Opinions: Vaccines in emerging markets (Latin America) - Opportunities in Brazil, Mexico and Argentina 14Zweena Selects ITelagen to Host Personal Health Records Application 2Zweena Selects ITelagen to Host Personal Health Records Application 3
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: