Navigation Links
Skin Cells Turned Into Brain Cells in Lab Study
Date:6/7/2012

THURSDAY, June 7 (HealthDay News) -- Scientists who reprogrammed skin cells into brain cells say their research could lay the groundwork for new ways to treat Alzheimer's and other brain diseases.

The team at the Gladstone Institutes in San Francisco transferred a gene called Sox2 into both mouse and human skin cells. Within days, the skin cells transformed into early-stage brain stem cells called induced neural stem cells.

These cells began to self-renew and soon matured into neurons capable of transmitting electrical signals. Within a month, these new neurons had developed into neural networks, according to the research published online June 7 in the journal Cell Stem Cell.

These transformed cells could provide better models for testing new drugs to treat Alzheimer's and other brain diseases, the researchers said.

"Many drug candidates -- especially those developed for neurodegenerative diseases -- fail in clinical trials because current models don't accurately predict the drug's effects on the human brain," Gladstone investigator Dr. Yadong Huang, who is also an associate professor of neurology at the University of California, San Francisco, said in a Gladstone news release.

"Human neurons -- derived from reengineered skin cells -- could help assess the efficacy and safety of these drugs, thereby reducing risks and resources associated with human trials," Huang explained.

About 5.4 million people in the United States have Alzheimer's disease and that number is expected to triple by 2050., the release notes. Currently, there are no approved drug treatments to prevent or reverse the disease.

More information

The U.S. National Institute on Aging has more about Alzheimer's disease.

-- Robert Preidt

SOURCE: Gladstone Institutes, news release, June 7, 2012


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Applied nanobiomedicine: Exploiting nanoparticles to hunt for hidden cancer cells
2. 3 types of fetal cells can migrate into maternal organs during pregnancy
3. Modeling the demise of migrating brain tumor cells
4. Researchers identify a life-and-death molecule on chronic leukemia cells
5. The cells petrol pump is finally identified
6. McMaster University researchers discover drug destroys human cancer stem cells but not healthy ones
7. Neuron-nourishing cells appear to retaliate in Alzheimers
8. Study: Heart damage after chemo linked to stress in cardiac cells
9. Scientists discover marker to identify, attack breast cancer stem cells
10. All cancer cells are not created equal
11. Drug kills cancer cells by restoring faulty tumor suppressor
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Skin Cells Turned Into Brain Cells in Lab Study
(Date:10/12/2017)... , ... October 12, 2017 , ... ... to meet the demand of today’s consumer and regulatory authorities worldwide. From Children’s ... experts and tested to meet the highest standard. , These products are ...
(Date:10/12/2017)... ... October 12, 2017 , ... Asante, a nationally ... care, have expanded their existing home health joint venture through an agreement, effective ... operating a joint venture home health company with Asante, delivering clinically integrated care, ...
(Date:10/12/2017)... ... October 12, 2017 , ... HMP , a leader in healthcare ... Folio Magazine Eddie Digital Award for ‘Best B-to-B Healthcare Website.’ Winners were announced during ... , The annual award competition recognizes editorial and design excellence across a range of ...
(Date:10/12/2017)... Mich. (PRWEB) , ... October 12, 2017 , ... ... has been named one of Michigan’s 2017 Best and Brightest in Wellness® by ... Brightest in Wellness® awards program on Friday, Oct. 20 from 7:30 a.m. to ...
(Date:10/12/2017)... , ... October 12, 2017 , ... ... latest in wound care advancements to physician colleagues, skilled nursing facility medical directors ... "Navigating the Treacherous Waters of Wound Care." , "At many of these conferences ...
Breaking Medicine News(10 mins):
(Date:10/5/2017)...  In response to the nationwide opioid epidemic, ... (AAOMS) released prescribing recommendations that urge ibuprofen – ... a first-line therapy to manage a patient,s acute ... Recognizing the value and importance of the ... Acute and Postoperative Pain Management" stresses that practitioners ...
(Date:10/2/2017)... , Oct. 2, 2017  Eli Lilly and Company ... results for the third quarter of 2017 on Tuesday, ... call on that day with the investment community and ... The conference call will begin at 9 a.m. ... access a live webcast of the conference call through ...
(Date:9/28/2017)... , Sept. 28, 2017 Cohen Veterans ... advance the use of wearable and home sensors for ... disorders. Early Signal Foundation, a nonprofit organization focused on ... will provide an affordable analytical system to record and ... ...
Breaking Medicine Technology: