Navigation Links
Skin Cell Transplant May Offer New Hope to Vitiligo Patients
Date:6/23/2012

By Jenifer Goodwin
HealthDay Reporter

FRIDAY, June 22 (HealthDay News) -- Skin cell transplants can restore pigment to the skin of some patients with the disorder known as vitiligo, new research finds.

Vitiligo is a skin condition in which melanocytes, or the cells in skin that produce pigment, are destroyed. The result is the skin loses color, often in patches. Vitiligo affects about one in every 200 people in the United States.

In the study, researchers from Henry Ford Hospital in Detroit removed a postage stamp-sized sample of skin from the upper thighs of 23 patients. Participants ranged in age from 18 to 60 and included whites, blacks, Asians and Hispanics.

Researchers then isolated melanocytes and keratinocytes, another type of skin cell, into a liquid solution.

Next, researchers used a device called a dermabrader to scrape off the white patches of skin, and sprayed the liquid containing the skin cells onto the skin, allowing it to disperse over the entire white patch. The area was then covered in dressings for about a week.

Gradually, the transplant, including the melanocytes, took hold and began to grow. Over the course of one to six months, color gradually returned to the white patches.

On average, the skin regained about 45 percent of its original color, although some patients saw better results than others.

The technique worked best in people who have what's known as "focal" or "segmental" vitiligo, in which color is lost only on one portion or side of the face or body, while the other is normally pigmented. On average, they had about 68 percent of their natural color return.

The treatment didn't work as well in people with "symmetrical" vitiligo, or pigment loss on both sides of the body or face, said senior study author Dr. Iltefat Hamzavi, a senior staff physician in Henry Ford's department of dermatology.

Researchers believe the immune system is more active in those patients, and continues to destroy color-producing cells, including the transplanted ones.

"This is a step forward but it's not a solution for everybody," Hamzavi said.

There were few complications. No patients developed an infection, and only one patient developed mild scarring, he said.

The study was published in a recent issue of the Journal of the American Academy of Dermatology.

Although this is among the first published studies on using skin cell transplants to treat vitiligo in the United States, a similar technique has been used in India and Saudi Arabia, Hamzavi said.

Vitiligo can occur at any age, but it often strikes when people are in their teens and 20s, Hamzavi said. It can be an especially difficult time for people to deal with the cosmetic issues of the disease, he added.

Among the patients who had the procedure done, one admitted he would wear bandages on his face in public to avoid stares; others avoided socializing, Hamzavi said. After their pigment was restored, the patients no longer practiced these behaviors, he said.

It's unknown how long the color remains intact. Researchers followed patients until about six months and none had lost color, while initial reports from Saudi Arabia and India have also not described color loss over time, Hamzavi said.

The researchers are continuing to offer the procedure at their hospital, and Hamzavi said they handle several cases per month.

Dr. Michele Green, a dermatologist at Lenox Hill Hospital in New York City, said the technique would be welcomed by many patients and dermatologists. Currently, there isn't much in the way of treatments for vitiligo, Green noted.

"It's amazing, if it's really as good as they say it is," Green said. "There are some laser [procedures] that are mildly effective, but short of that there is no treatment for vitiligo. And it's cosmetically extremely disfiguring for these patients. It's really big news."

But, Green cautioned, more research needs to be done. Only 23 patients were treated this way, and not all were helped, she said.

In addition, more needs to be learned about who has the best chances of success with the treatment, including whether it works better on new-onset vitiligo or if it works as well if people have had the disease for many years.

"It's a great preliminary study and very promising, but more investigation needs to be done," Green said.

More information

The U.S. National Institute of Arthritis and Musculoskeletal and Skin Diseases has more on vitiligo.

SOURCES: Iltefat Hamzavi, M.D., senior staff physician, Henry Ford Hospital, Detroit; Michele Green, M.D., dermatologist, Lenox Hill Hospital, New York City; May 2012, Journal of the American Academy of Dermatology


'/>"/>
Copyright©2012 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Exercise program improved health of lung transplant patients and cut cardiovascular risk
2. Survival rates lower for heart transplant patients whose arteries reclose after stenting
3. Pediatric kidney expert receives Young Investigator Award from American Transplant Congress
4. Haematopoietic stem cell transplantation increases survival in systemic sclerosis patients
5. Skin transplant offers new hope for vitiligo patients
6. Use of Smokers Lungs for Transplant Has Pros, Cons
7. UCLA launches first face transplantation program in western US
8. Study shows antibiotic improves respiratory function in lung transplant patients
9. U.S. Liver Transplants Declining
10. Statins prevent cancer in heart transplant recipients
11. Lenalidomide prolongs disease control for multiple myeloma patients after stem cell transplant
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Skin Cell Transplant May Offer New Hope to Vitiligo Patients
(Date:4/28/2016)... (PRWEB) , ... April 28, 2016 , ... Cosmetic Town, ... website, cosmetictown.com . The forum section was recently revamped and upgraded to allow ... surgical techniques in use across the country. , According to the senior editor of ...
(Date:4/28/2016)... ... 28, 2016 , ... In many parts of the world, contamination from human ... is particularly true in underdeveloped parts of Africa where clean sources of food and ... in Tangier, Morocco, will examine this global health issue and consider how it compares ...
(Date:4/28/2016)... , ... April 28, 2016 ... ... provider of enterprise Data Center Infrastructure Management solutions, announces today the availability ... feature enhancements in the area of capacity management and optimization, providing new ...
(Date:4/28/2016)... ... April 28, 2016 , ... Amada Senior Care, premier provider of non-medical in-home ... – its San Antonio West location. Prior to entering the senior care industry, Amada ... opening of Amada San Antonio West will take place on Friday, April 29th. ...
(Date:4/28/2016)... Phoenix, AZ (PRWEB) , ... ... ... of the AnzuMedical™ Knowledge Sharing and Collaboration Platform™ , today announced ... The platform will provide efficient access to medical knowledge, educational resources, and ...
Breaking Medicine News(10 mins):
(Date:4/28/2016)... April 28, 2016 TapImmune,Inc. ... innovative peptide and gene-based immunotherapeutics and vaccines for the treatment ... presenting at the 3rd Annual Growth Capital Expo ... , 2016 at Caesars Palace in Las Vegas, Nevada.  ... Wednesday, May 4 th by Dr. John N. ...
(Date:4/27/2016)... 2016  Hologic, Inc. (Nasdaq: HOLX ... the fiscal second quarter ended March 26, 2016.  ... increased 41.2%, and non-GAAP diluted EPS of $0.47 ... on a reported basis, and 6.3% on a ... another good quarter, highlighted by 14.6% growth in ...
(Date:4/27/2016)... Avril 2016   ... +5% sur le trimestre, soutenu par une croissance ... Croissance de +16% des ventes aux hôpitaux ... Kea Technologies (Euronext : MKEA, FR0010609263 ; OTCQX : MKEAY), inventeur ... aujourd,hui son chiffre d,affaires pour le premier trimestre ...
Breaking Medicine Technology: