Navigation Links
Skeleton key for cancer metastasis
Date:4/26/2010

Cancer cells need all three of their cytoskeletonsactin, microtubules, and intermediate filamentsto metastasize, according to a study published online on April 26 in the Journal of Cell Biology (www.jcb.org).

A cancer cell in an epithelial layer is trapped unless it can force through the basement membrane, which cordons off the tissue. Tumor cells start to dissolve the basement membrane with enzymes that build up within extensions called invadopodia. How the different components of the cytoskeleton collaborate to spring the cell remains unclear. To find out, Danijela Vignjevic and colleagues (Institut Curie) followed cancer cells as they started their breakout.

They found that a tumor cell escapes in three stages. First, stumpy protrusions dig into the basement membrane. These structures then elongate into "mature" invadopodia. Finally, the rest of the cell follows. In culture, crawling cells produce extensions that carry either bundles of actin or an actin mesh. In the cancer cells, both forms of actin were necessary for invadopodia to form and grow. However, microtubules and intermediate filaments were only essential for invadopodia to lengthen.

The researchers suggest a model for this initial step of metastasis. Growing actin bundles push out a protrusion, which the actin mesh stabilizes as it elongates. Only if the invadopodium stretches beyond 5 microns do microtubules and intermediate filaments get involved. Microtubules most likely elongate the invadopodium by delivering materials such as enzymes to the tip. Intermediate filaments, meanwhile, may brace the growing extension.


'/>"/>

Contact: Rita Sullivan
news@rupress.org
212-327-8603
Rockefeller University Press
Source:Eurekalert  

Page: 1

Related medicine news :

1. Understanding causes of cancer and chronic disease: The Canadian Partnership for Tomorrow Project
2. Breast Cancer Risks Not Same for Hispanic Women
3. Breast cancer risk factors differ among races
4. Cancer research award to Johns Hopkins basic scientist
5. Prostate cancer: Risk increases with the number of affected family members
6. Major League Baseball Players Alumni Help Lazarex Cancer Foundation Raise Funds
7. BLUE Buffalo Pet Food and PETCO Partner to Fight Pet Cancer During Pet Cancer Awareness Month
8. Magnitude of overdiagnosis in cancer indicates need for strategies to address the problem
9. MU researchers show potential for new cancer detection and therapy method
10. Remedy Needed for Overdiagnosis of Cancers
11. “An Evening Of Hope” - Tonight is the Official Pre-Event for this Year's American Cancer Society Starry Night Gala
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Skeleton key for cancer metastasis
(Date:1/20/2017)... FL (PRWEB) , ... January 20, 2017 , ... ... and wellness products to enhance people’s everyday lives, recently attended the January ECRM ... buyers. , ATP Science is known for its large range of supplements that ...
(Date:1/20/2017)... California (PRWEB) , ... January 20, 2017 , ... "TransFlare ... to use inside of Final Cut Pro X," said Christina Austin - CEO of ... the RED Dragon. Utilizing the Dragon Sensor,TransFlare 4K Mystique lens flare and light leak ...
(Date:1/20/2017)... ... January 20, 2017 , ... “The Angel”: a heartwarming and ... out for each of his children. “The Angel” is the creation of published author, ... New York City, and impassioned writer. , When asked of her new book, Marjorie ...
(Date:1/20/2017)... ... January 20, 2017 , ... ... Oscillating Positive Expiratory Pressure (OPEP) device, was featured in a study indicating superior ... MEd, RRT-ACCS, FAARC, “Analysis of Three Oscillating Positive Expiratory Pressure Devices During ...
(Date:1/20/2017)... ... January 20, 2017 , ... “Knowledge is God’s Lighthouse”: ... faith. “Knowledge is God’s Lighthouse” is the creation of published author, Gene Gaapf, a ... poetry collections. , “I have been writing since high school and have many ...
Breaking Medicine News(10 mins):
(Date:1/20/2017)... -- Entscheidung fällt als Reaktion ... Die internationale humanitäre Stadt soll um knapp 2800 m² erweitert ... Seine Hoheit Scheich Muhammad bin Raschid Al ... Dubai , hat den Auftrag erteilt, ... City IHC) zu verdreifachen, um den Betrieb zur Unterstützung ...
(Date:1/19/2017)... -- The Global Therapy Partnering Terms and Agreements since ... and agreements entered into by the world,s leading healthcare ... deals by value - Deals listed by company A-Z, ... report provides understanding and access to the partnering deals ... companies. The report provides an analysis of partnering ...
(Date:1/19/2017)... Many patients don,t realize that they may ... pharmacy just a few blocks away charges only $25 ... Medicationdiscountcard.com has created a price comparison engine ... their medication will cost at most nearby pharmacies. ... Medicationdiscountcard.com takes all of the hassle ...
Breaking Medicine Technology: