Navigation Links
Size does matter: Researchers adapt drug dosing to body size
Date:3/10/2008

University of Queensland researchers are leading the charge in adapting drug dosing to a society that is changing shape.

As the level of obesity in the Western World continues to rise dramatically, UQ School of Pharmacy's Dr Bruce Green says researchers face the ongoing challenge of determining just how dosages should be adjusted for different body sizes and compositions.

In a pharmacological sense, obesity presents a challenging role for clinicians, as the effects of altered body composition on the time course of drug response are poorly understood, Dr Green said.

[This] lack of dosing information [is of additional concern when you] consider that many of these individuals require therapeutic intervention for a variety of disease states.

It is this shortfall that the School of Pharmacy's Modelling and Simulation Group is looking to redress, as they work to optimise dosages for a variety of drugs in the overweight population.

The purpose of this study is linked to our overall strategy of ensuring that patients who are overweight do not get overdosed by dosing on total body weight, or underdosed by giving fixed doses to all patients, Dr Green said.

We propose that drugs should be dosed on our formula for lean body weight to match drug exposure across individuals of differing body compositions.

The results should minimise adverse events and improve efficacy of drugs, which we have already shown in an individualised dosing trial for enoxaparin (a blood thinning drug).


'/>"/>

Contact: Dr. Bruce Green
greenb@pharmacy.uq.edu.au
61-733-653-179
Research Australia
Source:Eurekalert

Page: 1

Related medicine news :

1. Burroughs Wellcome Fund grants $9.75 million towards translational researchers
2. Researchers Design Promising Cancer Drug
3. Case Western Reserve University researchers identify colorectal cancer gene
4. On a roll: MIT researchers devise new cell-sorting system
5. Einstein researchers genetically engineer immune cells into potent weapons for battling HIV
6. Researchers control growth rate of replacement blood vessels, tissues
7. New protein discovery helps researchers understand autoimmune diseases
8. UF researchers warn parents about dangers of childhood foot burns
9. UCLA researchers find blood stem cells originate and are nurtured in the placenta
10. UCSF researchers validate new model for breast cancer risk assessment in multiple ethnic groups
11. Einstein researchers discover gene mutations linked to longer lifespans
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/7/2016)... ... 2016 , ... Baciocco Brothers Insurance Agency, a northern California ... region, is initiating a charity event to raise support and awareness for the ... center in Sacramento works to provide area teens and families with treatment programs ...
(Date:12/7/2016)... ... OCTOBER XX, 2016 (PRWEB) (PRWEB) December 07, ... ... mystery. A new study entitled “Canine Filamentous Dermatitis Associated with Borrelia Infection” ... in dogs. The study was published in the prestigious Journal of Veterinary Science ...
(Date:12/7/2016)... ... December 07, 2016 , ... ... condemning "scam operations" carried out by unethical locksmith companies and is urging Search ... a halt. According to Texas Premier Locksmith, these fraudulent locksmith services take advantage ...
(Date:12/7/2016)... ... December 07, 2016 , ... Bioelectronic ... Plus for consumers and healthcare professionals to manage chronic and acute pain. ... treatment modalities available in a single device. The announcement is part of ...
(Date:12/7/2016)... ... December 07, 2016 , ... “Fred Rides a Train” ... Day that follows. , “Fred Rides a Train” is the creation of published ... stories since her teen years in Michigan. The "Fred, the Dog" series is her ...
Breaking Medicine News(10 mins):
(Date:12/6/2016)... , Dec. 6, 2016  Licenders is bringing their 100% all-natural ... location in Park Slope at 203 13 th Street was ... clientele. "Our goal is to ease parents, ... are designed to get children right back to class without skipping ... all natural and safe for the whole family," Licenders President ...
(Date:12/6/2016)... , Dec. 6, 2016 Radioisotopes are radioactive ... are produced either by using nuclear research reactor or ... form of alpha, beta or gamma when changed to ... used in Nuclear medicine, specifically in medical diagnostics. In ... information about a human body,s functioning. Radiotherapy is also ...
(Date:12/6/2016)... 2016 Anaplastic Oligoastrocytoma - Pipeline Review, ... latest Pharmaceutical and Healthcare disease pipeline guide Anaplastic ... overview of the Anaplastic Oligoastrocytoma (Oncology) pipeline landscape. ... forms when two types of cells in the ... number to form a mass. These brain cells ...
Breaking Medicine Technology: