Navigation Links
Six new genetic variants linked to type 2 diabetes discovered in South Asians
Date:8/28/2011

An international team of researchers led by Imperial College London has identified six new genetic variants associated with type-2 diabetes in South Asians. The findings, published in Nature Genetics, give scientists new leads in the search for diagnostic markers and drug targets to prevent and treat this major disease.

People of South Asian ancestry are up to four times more likely than Europeans to develop type 2 diabetes, which is a major risk factor for heart disease and stroke. Around 55 million South Asian people are affected worldwide, and the number is projected to rise to 80 million by 2030.

This new study is the first to focus on genes underlying diabetes amongst people originating from South Asia (India, Pakistan, Sri Lanka and Bangladesh). The researchers from around the world examined the DNA of 18,731 people with type 2 diabetes and 39,856 healthy controls. The genomes of the participants were analysed to look for locations where variations were more common in those with diabetes. The results identified six positions where differences of a single letter in the genetic code were associated with type 2 diabetes, suggesting that nearby genes have a role in the disease.

Dr John Chambers, the senior author of the study, from the School of Public Health at Imperial College London, said: "Type 2 diabetes is more common in South Asian populations than any other ethnic group, but the reason for this increased risk is unclear. Although lifestyle factors such as unhealthy diet, physical inactivity and obesity are important causes of diabetes in South Asians, these are only part of the explanation. Genetic factors have been widely considered to play a role in the increased risk of type 2 diabetes in Asians, but to date have not been systematically explored in this population."

"Our study identifies six new genetic variants linked to type 2 diabetes in South Asians. Our findings give important new insight into the genes underlying of diabetes in this population, which in the long term might lead to new treatments to prevent diabetes."

Professor Jaspal S Kooner, from the National Heart and Lung Institute at Imperial College London, the lead author for the study said: "This is the first genome-wide association study in South Asians, who comprise one-quarter of the globe's population, and who carry a high burden of the disease and its complications, including heart attack and stroke. We have shown that the genetic variants discovered here in South Asians also exist and contribute to diabetes in Europeans. Our studies in Asians and European populations highlight the importance and gain in examining the same problem in different ethnic groups."

The collaboration included leading researchers from Imperial College London, University of Oxford, University of Cambridge, the University of Birmingham, and the Peninsular Medical School in the UK, as well National University of Singapore, University of Mauritius, Baker IDI (Australia), Mohan Diabetes Centre (India), University of Kelaniya (Sri Lanka), NCGM (Japan), University of Houston (USA), Aga Khan University (Pakistan) and other institutions.


'/>"/>

Contact: Sam Wong
sam.wong@imperial.ac.uk
44-020-759-42198
Imperial College London
Source:Eurekalert

Related medicine news :

1. Breakthrough in genetics of fibroids
2. Yale researchers use genetic code to engineer a living protein
3. Mayo Clinic wins grant to gauge genetic risk of heart attacks, adverse drug reactions
4. Honing in on the Genetics of MS
5. Stomach Cancer Tumors Have Genetic Differences: Researchers
6. Research discovers genetic link to Barretts esophagus, esophageal cancer
7. New study sheds light on role of genetics in recovering from eating disorders
8. UBC researchers create more powerful lab-on-a-chip for genetic analysis
9. Many Doctors Ignore Cancer Genetic Testing Guidelines
10. Genetic map of African-Americans to aid study of diseases, human evolution
11. Mayo researchers: Genetic mutation linked to Parkinsons disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/12/2016)... ... 12, 2016 , ... Young Asset Protection, a full service ... the latest charity campaign in their community enrichment program. Art Expression utilizes after-school ... cause are currently being accepted at: http://artexpressioninc.org/ . , Art Expression is ...
(Date:2/12/2016)... ... February 12, 2016 , ... J Thomas ... by continuing it’s commitment to act as Agents of Change in the community, ... with area homeless families to fulfill immediate needs and help them move into ...
(Date:2/12/2016)... Pa. (PRWEB) , ... February 12, 2016 , ... ... sort through a world of exterior design possibilities. CertainTeed, North America’s leading brand ... tools by expanding the product offerings showcased in the mobile version of the ...
(Date:2/12/2016)... ... February 12, 2016 , ... The Central Coast Autism Spectrum Center (CCASC) invites teens ages 11-18 ... night of fun for teens with and without special needs to gather in a safe ... the event. The dance will take place on Saturday, Feb. 13 from 7 to 9:30 ...
(Date:2/12/2016)... CA (PRWEB) , ... February 12, 2016 , ... ... Film Studios. The new cartoon style themes are great for showcasing pictures, videos as ... customized scene generators, titles like introductions, lower thirds, transitions and a beautiful frame overlay. ...
Breaking Medicine News(10 mins):
(Date:2/12/2016)... 12, 2016  Innophos Holdings, Inc. (NASDAQ: IPHS ), ... today announced that it will host a live conference call ... discuss its fourth quarter and full year 2015 results. ... release detailing fourth quarter and full year results will be ... --> --> The conference ...
(Date:2/12/2016)... -- SI-BONE, Inc., a medical device company that pioneered the use of ... (MIS) device indicated for fusion for certain disorders of the sacroiliac ... Administrative Contractor (MAC) covering the states of Connecticut ... Massachusetts , Minnesota , ... Rhode Island , Vermont ...
(Date:2/12/2016)... 2016 On Thursday, Feb. 11, 2016, surgeons ... David,s North Austin Medical Center successfully completed the first ... ® Surgical System with Trumpf Medical,s advanced operating ... Lakshman , M.D., colorectal surgeon at the Texas Institute ... Table Motion technology, which seamlessly combines the da Vinci ...
Breaking Medicine Technology: