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Six months hormone therapy in addition to radiotherapy improves prostate cancer survival
Date:4/6/2014

hs; the first was given on the first day of irradiation and the second three months later. When LH-RH analogues are first given, testosterone levels go up briefly before falling to very low levels. This effect is called flare and, in order to prevent it, the patients took an oral anti-androgen (bicalutamide, 50 mg per day) for 15 days before the first injection.

Doctors could chose between one of three irradiation doses, 70, 74 or 78 Grays (Gy). They followed up the men for an average of 7.2 years and found that, regardless of the radiotherapy dose and whether it was intensity modulated or not, the 403 men who had been treated with radiotherapy combined with hormone treatment were significantly less likely to have suffered a relapse and progression of their cancer than the 407 men who had been treated with radiotherapy alone. (Nine men did not receive the planned treatment).

Men receiving the combined treatment had nearly half the risk (47%) of biochemical progression of their disease compared to men treated with radiotherapy only. In the combined treatment group, 118 men had a biochemical progression of their disease compared with 201 men in the radiotherapy only group. (Biochemical progression was assessed according to whether or not PSA values had risen above the lowest level plus two nanograms per millilitre; if it had risen, then this required confirmation in subsequent checks).

Five years after their treatment, the men in the combined treatment group were doing significantly better. "They had better survival without biochemical progression," Prof Bolla will say. "Among those receiving the combined treatment, 17.5% had progressed compared to 30.7% receiving radiotherapy alone."

When the researchers looked at clinical progression of the disease whether the cancer had recurred, spread to other parts of the body (proven by biopsies and imaging) or the patients had died they found that five years after their treatment 88.7% of
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Contact: Emma Mason
wordmason@mac.com
European Society for Radiotherapy and Oncology (ESTRO)
Source:Eurekalert

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