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Six months hormone therapy in addition to radiotherapy improves prostate cancer survival
Date:4/6/2014

Vienna, Austria: Men with prostate cancer that is small and confined to the prostate gland but that is at risk of growing and spreading, do better if they are treated with radiotherapy combined with androgen deprivation therapy, which lowers their levels of the male hormone, testosterone, according to new research.

The findings, which will be presented at the 33rd conference of the European Society for Radiotherapy and Oncology (ESTRO33) in Vienna today (Monday), are expected to change clinical practice.

Professor Michel Bolla, a professor of radiation oncology at Grenoble University Hospital (Grenoble, France), will tell the conference: "Although we need longer follow-up to assess the impact on these men's overall survival, these findings need to be taken into account in daily clinical practice. They show that three-dimensional conformal radiotherapy, whether intensity modulated or not, and regardless of the dose level, has to be combined with short-term androgen deprivation therapy in order to obtain a significant decrease in the risk of relapse. Therefore, during multidisciplinary team meetings to discuss a patient's treatment, this combined treatment approach should be one of the options proposed for men with localised prostate cancer that has an intermediate or high risk of growing and spreading." [1]

Prof Bolla and colleagues from 37 centres in 14 countries recruited 819 men to a clinical trial. The patients had early stage prostate tumours (as confirmed by analyses of biopsy samples and levels of prostate specific antigen (PSA)) that were at intermediate or high risk of growing and spreading to other parts of the body. They were randomised to receive either radiotherapy alone or radiotherapy and two injections under the skin of hormone drugs called luteinizing hormone-releasing hormone analogues (LH-RH analogues), which lower levels of testosterone to cause reversible chemical castration. Each drug injection lasted three mont
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Contact: Emma Mason
wordmason@mac.com
European Society for Radiotherapy and Oncology (ESTRO)
Source:Eurekalert

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