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Six Investigators Awarded Lyme Research Alliance Grants
Date:5/23/2013

will then test compounds singly, and in combination with the PZA, to find an optimal treatment regimen for patients with chronic Lyme disease. 

  • LRA has also awarded a grant to Kim Lewis, Ph.D., Distinguished Professor and Director, Antimicrobial Discovery Center, Northeastern University, Boston, Massachusetts. Dr. Lewis, in collaboration with Brian Fallon, MD, MPH, Director of the Lyme and Tick-Borne Diseases Research Center at Columbia University, will focus on persisters and introduce a new, rapid method for determining antibiotic sensitivity. A particular variant of persisters will be studied to better understand chronic infection and several experimental compounds will be tested in an effort to eradicate persister populations. 
  • • Mechanisms in the brain responsible for chronic fatigue, cognitive deficits and pain in post-treatment Lyme disease are not well understood. Alla Landa, Ph.D., a postdoctoral research fellow, Department of Psychiatry at Columbia University, New York, has received a grant to study these phenomena through the use of functional magnetic resonance imaging (fMRI) of the brain. By better understanding the neural circuitry in persistent Lyme disease patients, targeted treatments can be developed. 

    • No comprehensive study has focused on biodiversity and tick-borne diseases in the upper Midwest. Dr. Leticia Gutierrez, DVM, Ph.D candidate, Biology Department, University of Missouri, St. Louis, in collaboration with Dr. Robert E. Ricklefs, has been awarded a grant to investigate whether tick-borne diseases will be less prevalent in undisturbed areas or if disease risks increase when humans make changes to the environment where rodent species abound. 

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