Navigation Links
Sisters Helping Sisters: A New Lupus Research Study to Follow Sisters of Lupus Patients
Date:3/29/2010

Scientists at the Feinstein Institute for Medical Research have embarked on a national search for sisters.

Manhasset, NY (Vocus) March 29, 2010 -- Scientists at the Feinstein Institute for Medical Research have embarked on a national search for sisters.

The SisSLE (Sisters of Women with Systemic Lupus Erythematosus) research study is looking for sisters: one with a diagnosis of systemic lupus erythematosus (SLE), an autoimmune disease and one (or more) who does not have lupus. Betty Diamond, MD, and Peter Gregersen, MD, designed the study to understand how individuals may progress to lupus. By following sister(s) of a lupus patient the hope is to identify the disease in its earliest, pre-symptomatic stage and track its progression over time. The pilot study will enroll 400 sisters over a 2-year period. Scientists will be able to identify auto-antibodies that play a role in lupus and study other changes in blood serum that may help predict disease. They will also be trying to figure out how auto-antibodies may interact with environmental factors to play a role in the development of lupus.

Lupus is nine times more common in women and the autoimmune disease can attack many different organs and tissues of the body. Lupus has a significant genetic component. The risk of developing SLE is .1 percent in the population and twice that in females. In first degree relatives the risk can be from 4 to 8 percent.

Feinstein’s Dr. Diamond, a world-renowned lupus research and director of the Center for Autoimmune and Musculoskeletal Disorders, is teaming up with geneticist Peter K. Gregersen, MD, who is director of the Robert S. Boas Center for Genomics and Human Genetics. They want to understand how people progress from the start of the autoimmune process to end up with severe disability. What scientists know about the epidemiology of the illness is this: If they follow 4,000 sisters with a sibling with lupus that 80 of them will develop the autoimmune disease at some point in their lives. They also know that some sisters with anti-DNA antibody in their blood will never get lupus. The question is why. Ultimately they want to figure out who those people are and whether the auto-antibodies in their blood can reveal something about why they got sick or not. Then, what if they can begin treating people at risk for lupus before the disease causes organ damage? Could they stave off more serious symptoms and provide people with a better quality of life? They are hoping that this study will be able to help fit these puzzle pieces together.

This study will be a collaborative effort nationwide. There may be more than half a million lupus patients and more than half will have been diagnosed before their 35th birthday. By crude estimates, it means that there are 300,000 people who got lupus in their 30s. If 70 percent have a sister that means that they have a population of 200,000 potential recruits for the study. They are ultimately looking to recruit 4,000 sisters. The plan is to also mine the genome to identify genes that put families at risk and start to link the various genes to the different symptoms of the disease.

The sisters who have anti-nuclear antibodies but no signs of disease will also help tell the story of how the body’s immune system fends off this autoimmune disease. Can they identify markers of progression to disease? Who will get lupus and when? “The healthy person will help us understand the disease,” Dr. Diamond said.

Women who were diagnosed with lupus between the ages of 10 and 35 are invited to join the study if they have a sister or sisters (also between the ages of 10 and 35) without a diagnosis of lupus. Half-sisters are welcome to join the SisSLE study as well. For more information call Bonnie Gonzales, RN, or Sally Kaplan, RN, at 877-698-9467 or email SisSLE(at)nshs(dot)edu or visit the website www.SisSLE.org.

Contact:
Jamie Talan, science writer-in-residence
(516) 562-1232
jtalan(at)nshs(dot)edu

###

Read the full story at http://www.prweb.com/releases/SisSLE/Lupus_research/prweb3795454.htm.


'/>"/>
Source: PRWeb
Copyright©2010 Vocus, Inc.
All rights reserved  

Related medicine news :

1. Cleveland Cavalier Darnell Jackson teams with Big Brothers Big Sisters of Greater Cleveland to Issue “Mentoring Challenge”
2. Sisters of Charity Health System Welcomes Mark Wiedt to its Business Development Team
3. The American Heart Association's The Heart of Diabetes Campaign is Helping Patients 'Know Your Diabetes' Better
4. LocalITCompanies.com now Helping Chicago, Dallas and Houston Businesses Find Pre-Screened IT Companies
5. New Treatments and Good Skin Care Helping Patients Control Acne and Rosacea
6. A Small Grass-roots Non-profit, Announces That They Haven't Gone Away and are Still Alive with Helping the Disadvantaged Children in Ukraine
7. Star of TVs The Doctors Helping Put Smiles on Faces of Needy Children in India
8. Doctor Joseph Racanelli is Helping Christina Get Back Her Shape After Brutal Attack
9. Leading U.S. Infertility Practice Opens Boston IVF The Maine Center in Portland, Helping Build Families in Maine
10. Helping Turn "WannabeWELLS" into Wise Consumers
11. Explorers Bounty Puffed Fruit Snacks Helping Parents Battle Summer Obesity
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Sisters Helping Sisters: A New Lupus Research Study to Follow Sisters of Lupus Patients
(Date:5/2/2016)... ... May 02, 2016 , ... WestHarbor Growth Partners, ... today the release of Grow Healthy Vending’s newly revamped brand campaign. Grow ... growing healthy vending providers in North America with locations across the United States ...
(Date:5/2/2016)... ... May 02, 2016 , ... East Los Angeles ... Currently, patients can visit Dr. Assili to receive any dental extraction treatment for $40 ... it expires June 30, 2016. With the lower price, patients can more easily afford ...
(Date:5/2/2016)... , ... May 02, 2016 , ... Further establishing itself ... announce that the new WHIMZEES Variety Value Boxes were selected from over 1,000 entrants ... Showcase Award. , WHIMZEES natural dental chews for dogs are a favorite product ...
(Date:5/2/2016)... ... May 02, 2016 , ... Visceral fat, also known ... the kidneys, liver and pancreas. If not properly addressed, visceral fat can lead ... Internal Medicine, Medical Oncology and Palliative Care, warns against the dangers of visceral ...
(Date:5/2/2016)... ... May 02, 2016 , ... According to an American Psychological ... girls are sexually abused before the age of 18. Of those who survive, many ... story and others. , In her new book, Lyah! Lyah! Pants on Fyah!, ...
Breaking Medicine News(10 mins):
(Date:4/29/2016)... , April 29, 2016 ... glyco-biology expertise, today announces the appointment of Dr. ... Dr. Zurlo is an oncologist with many years clinical ... and biotechnology industries. His last role was at Mologen ... of the Executive Board. Previously Dr. Zurlo held various ...
(Date:4/28/2016)... , April 28, 2016  While Abbott,s announced ... the company,s valve repair and stent business, healthcare ... places Abbott more firmly into patient monitoring.  Kalorama ... fastest growing device areas, with double-digit growth expected ... report,  Advanced Remote Patient Monitoring . ...
(Date:4/28/2016)... 28, 2016 ... Phillips und Stephen Schmidt ... ArisGlobal®, ein führender Anbieter cloudbasierter Softwarelösungen ... bekannt, dass neue Führungskräfte zum Team Sicherheit ... die vielfältige Erfahrungen mitbringen.  Dies wird die ...
Breaking Medicine Technology: