Navigation Links
Sirolimus therapy alleviates symptoms of lung disease LAM
Date:3/16/2011

WHAT: Sirolimus, a drug currently used to help prevent transplant rejection, can improve lung function and quality of life in individuals living with the lung disease lymphangioleiomyomatosis (LAM), according to the results of a new study sponsored and conducted in part by the National Heart, Lung, and Blood Institute (NHLBI) of the National Institutes of Health.

"Efficacy and Safety of Sirolimus in Lymphangioleiomyomatosis," will be published online March 16 in the New England Journal of Medicine.

LAM is a rare and progressive lung disease in which cancer-like cells infiltrate the lung, leading to shortness of breath, coughing, chest pain, and in many cases eventual respiratory failure. LAM affects almost exclusively women, primarily of child-bearing age. Though only around 1,000 women in the U.S. have diagnosed LAM, there may be many more as the disease is not well-diagnosed.

This international study, led by the University of Cincinnati, recruited 89 LAM patients to test sirolimus, a drug that can suppress rapid cell growth by blocking an overactive protein called mTOR. Sirolimus is already used as an immune suppressant for organ transplants and is also being tested as a cancer drug. mTOR is also highly active in the invading cells that cause LAM.

The participants took daily oral doses of sirolimus or placebo over 12 months and had their lung function measured at regular intervals. The primary measurement was forced expiratory volume (FEV1), or the volume of air that can be forced out in the first second after taking a deep breath. The sirolimus group displayed stable FEV1 levels over the 12-month treatment period, compared to a roughly 12% decline in the placebo group. The sirolimus group also showed other clinical improvements, and reported a greater ability to carry out day-to-day functions and a better quality of life.

Following the treatment period, the study participants underwent 12-mo
'/>"/>

Contact: NHLBI Communications Office
NHLBI_news@nhlbi.nih.gov
301-496-4236
NIH/National Heart, Lung and Blood Institute
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Research study explores gene therapy treatment to reduce symptoms of Parkinsons disease
2. University Hospitals Case Medical Center testing innovative heat therapy for premature ejaculation
3. Ohio State study: Targeted ovarian cancer therapy not cost-effective
4. Stroke patients benefit from family involvement in exercise therapy
5. Extra Tests Not a Deterrent to Experimental Cancer Therapy
6. Gene Therapy Against HIV Not a Proven Cure, Experts Say
7. WSU researcher creates patented personalized therapy that causes cancer cells to kill themselves
8. BUSM study shows chemoradiotherapy prior to surgery improves survival
9. Fish oil fights weight loss due to chemotherapy
10. Lack of health insurance limits hepatitis C patients access to latest antiviral therapy
11. Protective strategy shields primate ovaries from radiation-therapy-induced damage
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/22/2015)... January 23, 2015 Angelweddingdress is a famous ... invites its customers to follow it on Facebook, Twitter, and ... Valentine’s Day gift. Angelweddingdress draws a lottery every week. , ... to Feb. 28, 2015. Click Angelweddingdress homepage for ...
(Date:1/22/2015)... 23, 2015 AngelWeddingDress, the premier women’s ... maternity wedding dresses. View website of AngelWeddingDress.com ... for maternity wedding dresses online for a bridal party. ... high quality for them. Its maternity wedding dresses are ...
(Date:1/22/2015)... January 22, 2015 Juvent Sports ( ... the 2015 PGA Merchandise Show to bestow a Juvent ... female amateur golfer, Arlene McKitrick. The award commemorated and ... golf tournament win. She won her first amateur tournament ...
(Date:1/22/2015)... New York, New York (PRWEB) January 22, 2015 ... filed after Fresenius Medical Care recalled its GranuFlo ... the federal multidistrict litigation underway in U.S. District Court, ... an Order dated January 20th, the Court has remanded ...
(Date:1/22/2015)... 2015 For over 20 years, Dr. David Cruz ... Vista area has treated just about every type of injury ... And for those same twenty-plus years, the team at ... injuries with the best possible doctor. With the combined ...
Breaking Medicine News(10 mins):Health News:Angelweddingdress Invites Its Customers To Follow It On Facebook, Twitter, And Pinterest 2Health News:AngelWeddingDress Has Recently Released Its Collection Of 2015 Maternity Wedding Dresses 2Health News:All-Time Leading Female Amateur Golfer Arlene McKitrick Receives Juvent Sports Achievement Award at 2015 PGA Show 2Health News:All-Time Leading Female Amateur Golfer Arlene McKitrick Receives Juvent Sports Achievement Award at 2015 PGA Show 3Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 2Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 3Health News:Court Overseeing Federal GranuFlo Lawsuits Remands Louisiana Claim Back to State Court, Bernstein Liebhard LLP Reports 4Health News:Industry Leading Chiropractor in Oceanside Joins the Doctors on Liens Network 2
... giants Cadbury have to pay heavily for the salmonella ... failed to inform the concerned authority about the possible ... of chocolates at their factory. They had supplied these ... many consumers. This was the breach of General Food ...
... It is a known fact that alcohol abuse and/or ... damage. //It is also known that women, more than ... a shorter period of drinking and with less overall ... also sustain greater cognitive damage than male alcoholics. ...
... achieving one of today’s Science greatest goals: allowing humans to ... well as from the UGR, researchers from the Spanish universities ... in this study, concluding that the consumption of melatonin – ... and present in many types of food – delays the ...
... has lodged a complaint with the West Bengal Human ... a patient died because the management// allegedly stopped medication ... 57, died on Saturday at the Mission of Mercy ... April 18 with diabetes, abdominal problem and cardiac ailments. ...
... Rajasthan will be fitted with an electronic biometric attendance system ... initially installed in a few primary schools, but later will ... first be installed in 15 schools of Jaipur and five ... already reached Bikaner. Initially, it would be used on an ...
... article published by the British Medical journal reveals that there has ... in the Asian region. This has become a// major strain on ... report the number of cases are expected to climb at the ... 156 to 100,000 as compared to 164 to 100,000 in the ...
Cached Medicine News:Health News:Cadbury Indicted on Salmonella Scare 2Health News:Cognitive Problems Occur More Rapidly in Female Alcoholics Than in Males 2Health News:Cognitive Problems Occur More Rapidly in Female Alcoholics Than in Males 3Health News:High Melatonin can Help Delay Ageing 2Health News:NRI Doctor Protests Patient's Death in Kolkata Hospital 2Health News:Cancer Time Bomb Threatening Economic Infrastructure 2
(Date:1/23/2015)... A lot of discussion in the medical community revolves ... injuries, or conditions. As medical science advances, doctors and surgeons ... that they consider to be more cutting edge. Yet, when ... method of treatment that stands out as the best solution ...
(Date:1/23/2015)... 2015  Northwest Biotherapeutics, Inc. (NASDAQ: NWBO )("NW Bio"), ... operable and inoperable solid tumor cancers, announced today that CEO ... Annual Phacilitate Immunotherapy Forum in Washington D.C. ... take place on January 26 at 10:30 a.m. EST at ...
(Date:1/23/2015)... Feffer LLP ( www.hfesq.com ) is investigating potential claims ... or the "Company") (NASDAQ: ADXS ), concerning ... shareholders. On January 21, 2015, an article ... had misrepresented the clinical data for its ADXS-HPV drug ...
Breaking Medicine Technology:No One-Size-Fits-All Remedy for Hernia Correction 2NW Bio To Present At The 7th Annual Phacilitate Immunotherapy Forum 2NW Bio To Present At The 7th Annual Phacilitate Immunotherapy Forum 3Harwood Feffer LLP Announces Investigation of Advaxis, Inc. 2
... , First-of-its-Kind Study Demonstrates REMICADE More Likely to Maintain ... , , CHICAGO, June 2 New ... with moderately to severely active Crohn,s disease having inadequate ... biologic therapy, were presented at Digestive Disease Week today. ...
... Insights into the Prediction of IBD Using Serology Testing ... Prometheus Laboratories Inc., a specialty pharmaceutical and diagnostic ... important serologic marker used in the detection of Crohn,s ... for celiac disease. In an oral presentation yesterday at ...
Cached Medicine Technology:New One-Year Data from REMICADE(R) SONIC Trial Show Sustained Efficacy Compared with Azathioprine in Treatment of Crohn's Disease 2New One-Year Data from REMICADE(R) SONIC Trial Show Sustained Efficacy Compared with Azathioprine in Treatment of Crohn's Disease 3New One-Year Data from REMICADE(R) SONIC Trial Show Sustained Efficacy Compared with Azathioprine in Treatment of Crohn's Disease 4New One-Year Data from REMICADE(R) SONIC Trial Show Sustained Efficacy Compared with Azathioprine in Treatment of Crohn's Disease 5New One-Year Data from REMICADE(R) SONIC Trial Show Sustained Efficacy Compared with Azathioprine in Treatment of Crohn's Disease 6New One-Year Data from REMICADE(R) SONIC Trial Show Sustained Efficacy Compared with Azathioprine in Treatment of Crohn's Disease 7New One-Year Data from REMICADE(R) SONIC Trial Show Sustained Efficacy Compared with Azathioprine in Treatment of Crohn's Disease 8New One-Year Data from REMICADE(R) SONIC Trial Show Sustained Efficacy Compared with Azathioprine in Treatment of Crohn's Disease 9Prometheus Announces New Findings Regarding Patients at Risk for Celiac Disease at DDW 2Prometheus Announces New Findings Regarding Patients at Risk for Celiac Disease at DDW 3