Navigation Links
Singular polymer, multiple functions
Date:11/19/2012

Akron, Ohio, Nov. 19, 2012 Working in the lab for the last few years, three generations of University of Akron polymer scientists say their mutual and passionate curiosity about science has led to their discovery of a first-of-its-kind, easily adaptable biocompatible polymer structure able to fight infection, filter water and perform a host of other functions.

Darrell Reneker, 82, distinguished professor of polymer science; Matthew Becker, 37, associate professor of polymer science; and 25-year-old graduate student Jukuan Zheng developed what they call a one-size-fits-all polymer system that can be fabricated and then specialized to perform healing functions ranging from fighting infection to wound healing. The research, "Post-Assembly Derivatization of Electrospun Nanofibers via Strain-Promoted Azide Alkyne Cycloaddition," is published in the Journal of the American Chemical Society at http://pubs.acs.org/doi/abs/10.1021/ja307647x?prevSearch=jukuan&searchHistoryKey.

The researchers devised a way to attach bioactive molecules to an electrospun polymer fiber mat, without compromising their biological functions. The possibilities for application should pique interest among developers and clinicians, say the scientists. Consider, for instance, Teflon-based vascular grafts used for aneurysm surgery since WWII being replaced by a strong, durable polymer structure with surface proteins that function as healthy blood vessels.

"We can design a blood vessel that can be put in different places and coated with different materials specific for the heart, specific for vascular, specific for the brain," Becker says.

Through the development, scientists for the first time place small molecules such as peptides, proteins, drugs and carbohydrates, which normally influence how cells behave, and attach therapeutic concentrations of chosen bioactive substances to the surfaces of an implant, after it has been fabricated. The bioactive efficacy and biocompatibility of the base surface then enables it to be implanted into the human body and perform healing functions that can save lives.

"There have been many types of polymers used in biomaterials, but the challenge with that has been, every time you make a new product it requires a new process," Becker explains. "This chemistry will be very useful in that you can manufacture many different implant products that contain the same kind of sites for attachment and put any of a wide variety of bioactive substances on the same kind of attachment site."

An unlimited number of biologic molecule types can be attached to the surface of a fibrous system, from antibiotics to fracture-healing vitamins.

"Imagine an emergency combat medic carrying around a box of bulky bandages to provide exactly the needed function from a larger number of possible needs," Reneker says. "This system provides choice without bulk."

Jukuan adds that he envisions the multifunctional development transitioning into an easy-to-use formula.

"This material will make life easier," he says. "People will just open a package, mix two ingredients and it will be ready to use."


'/>"/>
Contact: Denise Henry
henryd@uakron.edu
330-972-6477
University of Akron
Source:Eurekalert

Related medicine news :

1. Breakthrough nanoparticle halts multiple sclerosis
2. Multiple C-Sections Linked to Raised Complication Risks: Study
3. OHSU researchers discover potential way to repair brain damage in multiple sclerosis
4. Higher risk of maternal complications/preterm deliveries for women undergoing multiple cesareans
5. Higher risk of maternal complications/preterm deliveries for women undergoing multiple caesareans
6. New Pill Shows Promise Against Relapsing Multiple Sclerosis
7. Faculty from UCLA Center for Autism Research and Treatment receive multiple NIH awards
8. Added benefit of Cannabis sativa for spasticity due to multiple sclerosis is not proven
9. Pregnancy exposures determine risk of breast cancer in multiple generations of offspring
10. Multiple Methods Can Safely Help Babies Get to Sleep, Study Shows
11. Multiple Abortions May Raise Risk of Preemie Birth Later
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... June 26, 2016 , ... PawPaws brand pet ... product that was developed to enhance the health of felines. The formula is all-natural ... two main herbs in the PawPaws Cat Kidney Support Supplement Soft Chews ...
(Date:6/25/2016)... ... ... The temporary closing of Bruton Memorial Library on June 21 due to a possible lice ... overlooked aspect of head lice: the parasite’s ability to live away from a human host, ... a necessary one in the event that lice have simply gotten out of control. , ...
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, ... Bronze Wellness at Work award to iHire in recognition of their exemplary accomplishments in ... the 7th annual Maryland Workplace Health & Wellness Symposium at the BWI Marriott in ...
(Date:6/24/2016)... ... June 24, 2016 , ... Marcy was in a crisis. Her son James, eight, ... at his family verbally and physically. , “When something upset him, he couldn’t control his ... it. He would throw rocks at my other children and say he was going to ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... Topical BioMedics, Inc, makers of Topricin and ... that call for a minimum wage raise to $12 an hour by 2020 and then ... will restore the lost value of the minimum wage, assure the wage floor does not ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... SAN CLEMENTE, Calif. , June 24, 2016  American ... function testing company, is now able to perform sophisticated lung assessments ... ndd Medical Technologies , Inc. Patients are no ...  Thanks to ndd,s EasyOne PRO ® , ARL patients like Jeanne ... needed testing done in the comfort of her own home. ...
(Date:6/24/2016)... June 24, 2016   Pulmatrix, Inc ., (NASDAQ: ... innovative inhaled drugs, announced today that it was added ... reconstituted its comprehensive set of U.S. and global ... is an important milestone for Pulmatrix," said Chief Executive ... awareness of our progress in developing drugs for crucial ...
(Date:6/23/2016)... 23, 2016  MedSource announced today that it ... software solution of choice.  This latest decision demonstrates ... to their clients by offering a state-of-the-art electronic ... establishes nowEDC as the EDC platform of choice ... clients.  "nowEDC has long been a preferred EDC ...
Breaking Medicine Technology: