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Single vaccines to protect against both rabies and Ebola
Date:8/25/2011

protect these people from two very lethal diseases in an area where they don't have the best access to medical care."

The purpose of this study was to identify novel vaccine candidates for Ebola with a maximum potential of licensure and utilization.

Researchers generated a chemically inactivated and live rabies virus expressing the Ebola Zare species glycoprotein using a reverse genetics system based on the commonly-used rabies vaccine. Immunizations with those vaccines, the researchers found, induced immunity against each virus and conferred protection from both viruses in mice.

Piggy backing, in a sense, on the rabies vaccine could accelerate development of vaccines that protects against Ebola because of the advanced state of the rabies vaccine's safety, production and distribution, according to Schnell.

"After the vaccine has been tested in primates and eventually humans, this new vaccine could kill the proverbially two birds with one stone," he said.

There are implications for nonhumans, toogorillas, in particular. The Ebola virus has eradicated thousands of gorillas, prompting the World Conservation Union to raise their status to "critically endangered" in 2007, the first time a mammal has become critically endangered as a direct result of disease. Vaccinations, though challenging, could stall those deaths.

What's more, several human outbreaks have been attributed to primate interaction or handling, so providing a vaccine for our closest relative could minimize that risk.


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Contact: Steve Graff
stephen.graff@jefferson.edu
215-955-6300
Thomas Jefferson University
Source:Eurekalert  

Page: 1 2

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