Navigation Links
Single traumatic brain injury may prompt long-term neurodegeneration
Date:7/18/2011

PHILADELPHIA - Years after a single traumatic brain injury (TBI), survivors still show changes in their brains. In a new study, researchers from the Perelman School of Medicine at the University of Pennsylvania suggest that Alzheimer's disease-like neurodegeneration may be initiated or accelerated following a single traumatic brain injury, even in young adults.

Over 1.7 million Americans suffer a traumatic brain injury each year, and beyond the immediate effects, growing evidence demonstrates that a single TBI may initiate long-term processes that further damage the brain. TBI is an established risk factor for later development of cognitive impairments, such as Alzheimer's disease.

"A single traumatic brain injury is very serious, both initially, and as we're now learning, even later in life," said Douglas Smith, MD, professor of Neurosurgery and director of the Center for Brain Injury and Repair at Penn's Perelman School of Medicine, the study's co-senior author. "Plaques and tangles are appearing abnormally early in life, apparently initiated or accelerated by a single TBI."

The study appears online in Brain Pathology, and was done in conjunction with neuropathologist Dr. William Stewart, from the University of Glasgow and Southern General Hospital in Glasgow, UK.

The researchers found both tau tangles and amyloid-beta plaques in survivors, years after a single moderate-to-severe TBI. In repetitive head injury, previous studies have shown a tau accumulation as the signature pathology of a condition called chronic traumatic encephalopathy. In studies of people less than 4 weeks after dying from a single TBI, no similar tau pathology was found. In addition, while widespread amyloid-beta plaques have been found in about 30 percent of people shortly after injury, previous work showed that plaques disappeared within months.

In this study, researchers examined post-mortem brains from 39 long-term survivors of a
'/>"/>

Contact: Kim Menard
kim.menard@uphs.upenn.edu
215-662-6183
University of Pennsylvania School of Medicine
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Single Reading Cant Gauge Blood Pressure Control: Study
2. Single moms entering midlife may lead to public health crisis
3. Single bioptic telescope for low vision driving may not obscure road view of second eye
4. Single Gene Linked to Evolution of Human Brain
5. Advanced technology reveals activity of single neurons during seizures
6. Single gene defect causes brain tumor
7. See how they grow: Monitoring single bacteria without a microscope
8. Cancer in a single catastrophe
9. Scientists Aim for Test That Spots Single Cancer Cell in Blood Sample
10. Scientists Aim for Test That Could Spot Single Cancer Cell in Blood
11. Single Embryo Beat Double Embryo Transfer in IVF Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/25/2014)... CA (PRWEB) October 25, 2014 ... biology, today announced Dr. Xun Wang ... all Research & Development. , Triton has developed a ... value algae-based proteins. According to Dr. Wang, the platform ... traditional expression systems. He says, “Algae are unique because ...
(Date:10/25/2014)... (PRWEB) October 25, 2014 The global ... CAGR of 7.6%, to reach $50.4 billion by 2018 ... healthcare systems industry, and pharmaceutical industry are driving the ... model to enhance their focus on core business, reduce ... and trained staff (further reducing hiring and training costs), ...
(Date:10/25/2014)... Background: , In 1998 Bob Savage founded the Connecticut ... the field of establishing recovery community organizations. Bob had ... he retired, he set out to answer a couple questions ... , 1. Where are the people in recovery when ... Can the recovery community be organized to advocate for issues ...
(Date:10/25/2014)... 2014 Market Research Report ... 2009-2019 is a professional and in-depth market ... industry. The report firstly reviews the basic ... application and manufacturing technology. The report then ... Molecular Diagnostics listing their product specification, capacity, ...
(Date:10/25/2014)... York (PRWEB) October 25, 2014 ... lawsuits ( http://www.vaginalmeshlawsuit2015.com/ ) filed against Boston ... in U.S. District Court, Southern District of West ... Judgment on Punitive Damages in a group of ... a ruling issued on October 21st, U.S. District ...
Breaking Medicine News(10 mins):Health News:Triton Algae Innovations Ltd. Names Dr. Xun Wang as President 2Health News:Triton Algae Innovations Ltd. Names Dr. Xun Wang as President 3Health News:Global HCIT Outsourcing Market to Grow at 7.6% CAGR to 2018 Says a Premium Research Report Available at ReportsnReports.com 2Health News:Global HCIT Outsourcing Market to Grow at 7.6% CAGR to 2018 Says a Premium Research Report Available at ReportsnReports.com 3Health News:Global HCIT Outsourcing Market to Grow at 7.6% CAGR to 2018 Says a Premium Research Report Available at ReportsnReports.com 4Health News:CCAR Accepting Nominations for the Bob Savage Recovery Advocate of the Year Award 2Health News:Global and China Molecular Diagnostics Industry Analysis to 2019 is Now Available at RnRMarketResearch.com 2Health News:Global and China Molecular Diagnostics Industry Analysis to 2019 is Now Available at RnRMarketResearch.com 3Health News:Global and China Molecular Diagnostics Industry Analysis to 2019 is Now Available at RnRMarketResearch.com 4Health News:Transvaginal Mesh Lawsuits Move Forward, As Federal Judge Denies Motion for Summary Judgment on Punitive Damages in Florida Cases, Bernstein Liebhard LLP Reports 2Health News:Transvaginal Mesh Lawsuits Move Forward, As Federal Judge Denies Motion for Summary Judgment on Punitive Damages in Florida Cases, Bernstein Liebhard LLP Reports 3Health News:Transvaginal Mesh Lawsuits Move Forward, As Federal Judge Denies Motion for Summary Judgment on Punitive Damages in Florida Cases, Bernstein Liebhard LLP Reports 4
... Resources, an,association management and consulting firm for non-profit organizations,located ... launch of an,innovative e-learning solution to be used by ... of the service will offer a way to,increase revenue ... , "We,re excited about this ...
... CORTLANDT MANOR, N.Y., Feb. 3 Polymedco is pleased to ... and screening. It is designed to educate both patients ... cancer. The website is located at www.fobt-tests.com . ... cancer related death today in the United States. However, ...
... of change echoing across the country, Americans have been ... greatness of this nation. America,s ability to seize this ... by each individual. In celebration of the inherent excellence ... forum in which everyday stories of greatness will be ...
... Aldridge LLP (MLA) is pleased to announce that Paul ... has joined the firm in our Government Contracts Department. ... firm,s Life Sciences and Public Health Preparedness practice in ... addition to helping clients develop strategies for offering their ...
... Mich., Feb. 3 Cherries are not only good for ... According to recent,data, more than 9 out of 10 Americans ... say they,re purchasing "locally produced" products,and the majority are defining ... About ninety-five percent of cherries consumed in ...
... 3 To mark American Heart,Month, deCODE genetics (Nasdaq: ... of,February it will offer its deCODEme Cardio Scan(TM), the ... inherited risk of heart,attack, stroke and atrial fibrillation, intracranial ... promotional price of,$100. , On ...
Cached Medicine News:Health News:Center for Association Resources Launches E-Learning Service 2Health News:Nature Made(R) Seeking Stories of Individual Greatness for Upcoming Documentary 2Health News:Nature Made(R) Seeking Stories of Individual Greatness for Upcoming Documentary 3Health News:Former Assistant Secretary of Defense for Homeland Defense Joins McKenna Long & Aldridge LLP 2Health News:Cherries: 'America's Super Fruit' Offers Homegrown Health Benefits 2Health News:Cherries: 'America's Super Fruit' Offers Homegrown Health Benefits 3Health News:deCODEme(TM) Takes on Heart Disease in February 2Health News:deCODEme(TM) Takes on Heart Disease in February 3Health News:deCODEme(TM) Takes on Heart Disease in February 4Health News:deCODEme(TM) Takes on Heart Disease in February 5
(Date:10/25/2014)...  In 2008, two of Dr. Gurney,s employees reported ... substances, on a regular basis, that were not used ... was practicing "all the time" while under the influence. ... said that Dr. Gurney was prone to "making mistakes ... Dr. Gurney,s behavior became increasingly erratic and unfocused, and ...
(Date:10/25/2014)... , Oct. 24, 2014 In conjunction ... quarter 2014 financial results press release, you are invited ... broadcast live over the internet on Monday, November 3, ... Time). A live audio webcast of the ... http://www.durect.com and clicking "Investor Relations."  If you ...
(Date:10/25/2014)... , Oct. 24, 2014 Burzynski Research Institute, ... Drug Administration (FDA) has given the company permission to ... in patients > 3 months of age with a ... placed in one of five treatment groups based on ... prior treatment for DIPG. The primary study endpoint is ...
Breaking Medicine Technology:Doctors That Harm: The Real Stories Insurance Companies Against Prop 46 Don't Want You To Know, Part 8 of Consumer Watchdog Campaign Series 2Doctors That Harm: The Real Stories Insurance Companies Against Prop 46 Don't Want You To Know, Part 8 of Consumer Watchdog Campaign Series 3DURECT Corporation Invites You to Join its Third Quarter 2014 Earnings Conference Call 2Burzynski Research Institute, Inc. Announces FDA Permission to Launch a New Clinical Trial in Diffuse Intrinsic Brainstem Glioma 2
... Family of infusion pumps are ... collective series of administration sets. ... offers a wide variety of ... each featuring the patented Flo-Stop ...
... The Signature Edition GOLD Infusion ... from customer input, as well as ... Human factors design refers to ... with controls and displays engineered to ...
... instruments have been designed to provide ... tool for situations requiring precise hemostasis. ... 25 gauge intraocular, bipolar, diathermy instruments. ... target tissues for fine-tip hemostasis or ...
Developed in a Microsoft Windows environment, MedInformatix provides physician practices a Computerized Patient Record (CPR) with a Practice Management System (PMS) that is both integrated and design...
Medicine Products: