Navigation Links
Single microRNA fine-tunes innate immune response
Date:2/19/2008

ulate gene expression.) By knocking out Mefc2, the authors found that some of the effects caused by microRNA-223 were eliminated.

The researchers demonstrated that mice modified to lack microRNA-223 expression had up to three times as many granulocytes in their bone marrow and blood. Moreover, the granulocytes matured more rapidly and then reacted more aggressively to stimuli. This increased activity caused tissue inflammation and damage within the lungs with age or, in an acute inflammation model, within the liver, muscle and kidneys.

If you have an infection in the lungs, granulocytes will migrate to the site of the infection and attack, says Jonathan Johnnidis, first author of the paper and a former technician in the Camargo lab, and now a graduate student in molecular biology at the University of Pennsylvania. Once the infection is cleared granulocytes usually migrate away and settle down. However, in this case they didnt stand down after they were done fighting. Instead they continued an inflammatory response that did more damage.

Like a hand grenade once you pop the trigger out, these granulocytes are going to explode, regardless of whether they are surrounded by healthy tissue or harmful bacteria, adds Camargo. Lack of microRNA-223 makes it much easier to activate the grenade.

Camargo plans to further investigate the effect of this microRNA on disease. Our work suggests that microRNA-223 physiologically fine-tunes both the generation and function of granulocytic cells, delimiting their production and preventing excessive activation, he says. Also, since many forms of leukemia express diminished levels of microRNA-223, we are investigating how silencing of this microRNA may contribute to the development of that disease.


'/>"/>

Contact: Cristin Carr
carr@wi.mit.edu
617-324-0460
Whitehead Institute for Biomedical Research
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Single Mutation in Mitochondrial DNA Weakens Heart, Muscles
2. Single reader with CAD more efficient, yields fewer false positives, and possibly more sensitive
3. Computer-Aided Detection in Screening Mammography Enhances Performance of a Single Reader
4. Morphine dependency blocked by single genetic change
5. Novare Announces Completion of 100th Single Port Laparoscopic Procedure Using RealHand(R) High Dexterity (HD) Instruments
6. Pharmion and Methylgene Report Favorable Results for Phase 2 MGCD0103 Single- Agent Studies in Relapsed or Refractory Lymphomas at the 49th American Society of Hematology (ASH) Meeting
7. Transports Phase 2 Data Show Single Treatment SoloVir(TM) ETS Significantly Stops Progression of Cold Sore Episode
8. JRRD releases single-topic issue on traumatic brain injury and polytrauma
9. More women are choosing double mastectomy even when breast cancer is confined to a single breast
10. Alexza and Autoliv Announce Commercial Manufacturing and Supply Agreement for Heat Packages Used in Single-Dose Staccato(R) System
11. Methodist Health System Foundation Announces Largest Single Gift
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/19/2014)... B. E. Smith, the only full-service leadership ... retained to lead a national chief financial officer ... The top executive search firm in the healthcare industry, ... healthcare executives into organizations. , Johnson Memorial Hospital ... to the residents of Johnson County and the surrounding ...
(Date:12/19/2014)... December 19, 2014 Novellus Healthcare ... Care: Pharmacy & Clinics™, an independent journal that ... treating and caring for patients inside the pharmacy ... expands to provide optimal access to quality care, ... forum for the team treating and coordinating patient ...
(Date:12/19/2014)... 2014 Pain Free Living a leader ... announce a new Superior magnetic necklace using ... the strongest neodymium magnets for the fastest pain relief ... the Superior Magnetics brand for the fastest relief by ... magnetic therapy using Superior Magnetic Jewelry at fairs and ...
(Date:12/19/2014)... December 19, 2014 From November 24, 2014, ... training for the year 2014 in its Goa retreat ... year. Through the Indian winters, from November to March, Siddhi ... beautiful beach of Arambol, Goa. The Goa training sessions will ... intakes of yoga teacher training, the 10th intake is also ...
(Date:12/19/2014)... December 19, 2014 After a 13-year ... is again returning to the stage to entertain his ... for concert performances, and the successful tour has been ... announced. , Visit Ticketability.com for a ... Detroit shows at fair prices. , Music fans have ...
Breaking Medicine News(10 mins):Health News:Johnson Memorial Hospital Retains B. E. Smith to Recruit New Chief Financial Officer 2Health News:Johnson Memorial Hospital Retains B. E. Smith to Recruit New Chief Financial Officer 3Health News:The Transformation of Retail Pharmacies into a Healthcare Delivery Center 2Health News:The Transformation of Retail Pharmacies into a Healthcare Delivery Center 3Health News:New Superior Magnetic Necklace Relieves Migraine Headache 2Health News:Siddhi Yoga’s 10th intake of YTT started in Goa on November 24, 2014 2Health News:Siddhi Yoga’s 10th intake of YTT started in Goa on November 24, 2014 3Health News:Garth Brooks Tickets for Joe Louis Arena: Ticketability.com Becomes a Popular Destination for Discount Tickets for Garth Brooks’ Detroit Concerts Set for February 27-28 2
... United Kingdom: Cleaning is doubly beneficial, for it ensures two ... mentally cleanses the cleaner //(Lady of the House!) Women, spoke ... put things in order, but the flip side to it, ... ‘cleaning’ became so obsessive that they could be called “Cleanoholics” ...
... Society for Women's Health Research has found that 62 percent ... symptom occurs more in women than in men and is ... ,Some of the changes that occur are like burning, ... to light. The survey quizzed 304 women ages 45 to ...
... lot of ground work has to be done along with the ... who lack health insurance.// It is one of growing issues and ... County, US is at the epicenter of this huge medical crisis. ... in the country. This poses a severe set back both in ...
... embedded in a tribal’s chest two weeks ago. Till the ... was moving around normally as if nothing has happened. ... 7 by an arrow by fellow tribesman Kaliya when he ... pulled out the stem of the arrow, the head remained ...
... a chance to learn yoga, as Haryana is planning to ... ,State Education Minister Phool Chand Mullana said he ... itself. ,Mullana, who attended Ramdev's yoga training camp ... consultations would be held with the spiritual guru to train ...
... have not lessened the pain of losing their mentally ... his wife Meenakshi to run free counselling// sessions here ... ,The Trivedis were shattered when seven-year-old Ammi died ... her, but nothing helped. After her death, the couple ...
Cached Medicine News:Health News:Health Insurance Fueling Medical Crisis in US 2Health News:Distressed Couple Assists Parents Of Mentally Challenged Kids 2
(Date:12/17/2014)... RALEIGH, N.C. , Dec. 17, ... (CTMC), and Integrated Clinical Trial Services, LLC (ICTS), ... for clinical trials announce that they have formed ... Services (i-CTMS). i-CTMS will provide a broad range ... biotechnology and medical device companies. i-CTMS ...
(Date:12/15/2014)... 12, 2014 Research and Markets ( ... "Electrocardiogram (ECG) Devices - Global Trends, Estimates and Forecasts, ... http://photos.prnewswire.com/prnh/20130307/600769 Global Electrocardiogram Devices ... 2016. The North America accounts ... while Europe claims approximately 27% ...
(Date:12/15/2014)... YORK and HERZLIYA PITUACH, Israel ... "Company") (NASDAQ: IMNP ) announced today that its ... the Board succeeding Dr. Daniel Teper who continues ... a member of Immune,s Board of Directors since 2013. ... "I am delighted to represent the interest of shareholders and ...
Breaking Medicine Technology:Integrated Clinical Trial Services and Clinical Trial Marketing Communications Form Joint Venture 2Integrated Clinical Trial Services and Clinical Trial Marketing Communications Form Joint Venture 3Electrocardiogram (ECG) Devices - Global Trends, Estimates and Forecasts, 2012-2018 2Electrocardiogram (ECG) Devices - Global Trends, Estimates and Forecasts, 2012-2018 3Electrocardiogram (ECG) Devices - Global Trends, Estimates and Forecasts, 2012-2018 4Immune Pharmaceuticals Elects Daniel Kazado as New Chairman of the Board. 2Immune Pharmaceuticals Elects Daniel Kazado as New Chairman of the Board. 3Immune Pharmaceuticals Elects Daniel Kazado as New Chairman of the Board. 4
... LAKE, N.J., Jan. 3, 2012  Arena Pharmaceuticals, Inc. (NASDAQ: ... has submitted its response to the Complete Response Letter (CRL) ... review of the lorcaserin New Drug Application (NDA). Lorcaserin is ... weight loss, in patients who are obese (Body Mass Index, ...
... Jan. 3, 2012 IDEXX Laboratories, Inc. (NASDAQ: ... 30 th Annual J.P. Morgan Healthcare Conference. Jonathan W. ... on the Company on Monday, January 9, 2012 at 2:30 ... California. Individuals can access the live audio webcast of the ...
Cached Medicine Technology:Arena Submits Response to FDA Complete Response Letter for Lorcaserin 2Arena Submits Response to FDA Complete Response Letter for Lorcaserin 3Arena Submits Response to FDA Complete Response Letter for Lorcaserin 4Arena Submits Response to FDA Complete Response Letter for Lorcaserin 5Arena Submits Response to FDA Complete Response Letter for Lorcaserin 6
Porous foundation 470 series....
The Opteon stem meets the challenge of providing a high-quality, cost-effective hip implant for the moderate demand patient....
Exactech's AcuMatch C-Series (cemented femoral stem) is designed to provide solutions to the problems which compromise both the short and long term successful outcome of cemented hip arthroplasty....
The link ribbed hip stem for cementless primary hip replacement surgery....
Medicine Products: