Navigation Links
Single microRNA fine-tunes innate immune response
Date:2/19/2008

ulate gene expression.) By knocking out Mefc2, the authors found that some of the effects caused by microRNA-223 were eliminated.

The researchers demonstrated that mice modified to lack microRNA-223 expression had up to three times as many granulocytes in their bone marrow and blood. Moreover, the granulocytes matured more rapidly and then reacted more aggressively to stimuli. This increased activity caused tissue inflammation and damage within the lungs with age or, in an acute inflammation model, within the liver, muscle and kidneys.

If you have an infection in the lungs, granulocytes will migrate to the site of the infection and attack, says Jonathan Johnnidis, first author of the paper and a former technician in the Camargo lab, and now a graduate student in molecular biology at the University of Pennsylvania. Once the infection is cleared granulocytes usually migrate away and settle down. However, in this case they didnt stand down after they were done fighting. Instead they continued an inflammatory response that did more damage.

Like a hand grenade once you pop the trigger out, these granulocytes are going to explode, regardless of whether they are surrounded by healthy tissue or harmful bacteria, adds Camargo. Lack of microRNA-223 makes it much easier to activate the grenade.

Camargo plans to further investigate the effect of this microRNA on disease. Our work suggests that microRNA-223 physiologically fine-tunes both the generation and function of granulocytic cells, delimiting their production and preventing excessive activation, he says. Also, since many forms of leukemia express diminished levels of microRNA-223, we are investigating how silencing of this microRNA may contribute to the development of that disease.


'/>"/>

Contact: Cristin Carr
carr@wi.mit.edu
617-324-0460
Whitehead Institute for Biomedical Research
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Single Mutation in Mitochondrial DNA Weakens Heart, Muscles
2. Single reader with CAD more efficient, yields fewer false positives, and possibly more sensitive
3. Computer-Aided Detection in Screening Mammography Enhances Performance of a Single Reader
4. Morphine dependency blocked by single genetic change
5. Novare Announces Completion of 100th Single Port Laparoscopic Procedure Using RealHand(R) High Dexterity (HD) Instruments
6. Pharmion and Methylgene Report Favorable Results for Phase 2 MGCD0103 Single- Agent Studies in Relapsed or Refractory Lymphomas at the 49th American Society of Hematology (ASH) Meeting
7. Transports Phase 2 Data Show Single Treatment SoloVir(TM) ETS Significantly Stops Progression of Cold Sore Episode
8. JRRD releases single-topic issue on traumatic brain injury and polytrauma
9. More women are choosing double mastectomy even when breast cancer is confined to a single breast
10. Alexza and Autoliv Announce Commercial Manufacturing and Supply Agreement for Heat Packages Used in Single-Dose Staccato(R) System
11. Methodist Health System Foundation Announces Largest Single Gift
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... Dennis Thompson HealthDay Reporter ... born with HIV who was thought to be cured by ... showing detectable levels of the AIDS-causing virus in her bloodstream, ... nearly 4 years old, had remained virus-free even though she ... Doctors had hoped her remission would open the door to ...
(Date:7/11/2014)... (PRWEB) July 11, 2014 The ... by Types, Applications & Geography - 2018,” defines ... fiber market with an analysis and forecast of ... specialty synthetic fibers (Para aramids, meta aramids, UHMW ... others including PPS fiber, PBI fiber, PBO fiber, ...
(Date:7/11/2014)... Operators and owners stand ... fuel costs now that model 2019 will ... standards are phasing in 2014-2018 standards. ... to install new features into their vehicles ... , 2.    Efficient driveline components which reduce friction ...
(Date:7/11/2014)... Ticket Down is a reliable source for cheap ... it comes to the summer concert schedule, it just isn’t complete ... one of the biggest names in country music and one of ... on his “That’s My Kind of Night” tour featuring Lee Brice ... making through the rest of the summer and into the fall ...
(Date:7/11/2014)... 2014 Global enterprises today are shifting ... day-to-day management activities. Managed services offer these global enterprises ... economic slowdown resulted into rising operational costs to companies. ... considered to be the global market driver for expanding ... global managed services market is estimated to grow from ...
Breaking Medicine News(10 mins):Health News:Mississippi Girl Thought Cured of HIV Shows Signs of Infection 2Health News:Mississippi Girl Thought Cured of HIV Shows Signs of Infection 3Health News:Specialty Synthetic Fibers & Glass Fiber Market Poised to Reach $20.1 Billion at a CAGR of 5.2% by 2018 – Report by MarketsandMarkets 2Health News:Specialty Synthetic Fibers & Glass Fiber Market Poised to Reach $20.1 Billion at a CAGR of 5.2% by 2018 – Report by MarketsandMarkets 3Health News:Specialty Synthetic Fibers & Glass Fiber Market Poised to Reach $20.1 Billion at a CAGR of 5.2% by 2018 – Report by MarketsandMarkets 4Health News:LeaseQ Agrees the Latest Round of Greenhouse Gas Rules Could Increase the Cost of Truck Acquisition and Maintenance 2Health News:LeaseQ Agrees the Latest Round of Greenhouse Gas Rules Could Increase the Cost of Truck Acquisition and Maintenance 3Health News:Luke Bryan Ticket Prices Slashed at Concord Pavilion 2Health News:Luke Bryan Ticket Prices Slashed at Concord Pavilion 3Health News:North America Managed Services Market Worth $68.65 Billion by 2018 - New Report by MicroMarket Monitor 2Health News:North America Managed Services Market Worth $68.65 Billion by 2018 - New Report by MicroMarket Monitor 3Health News:North America Managed Services Market Worth $68.65 Billion by 2018 - New Report by MicroMarket Monitor 4
... ... announcement that Newark, one of the leading electronic component distributors in the Americas, has ... , ... (PRWEB) November 17, 2009 -- NMB Technologies Corporation, a Minebea Group Company, announced today ...
... ... Seeks Users to Test, Evaluate , ... Bethesda, Md. and Northfield, Ill. (Vocus) November 17, 2009 -- The ... from SNOMED Clinical Terms® (SNOMED CT®) to the International Classification of Diseases, 9th revision, ...
... , Obesity-Attributable Health Spending to Reach ... 17 A new report ... Ken Thorpe, Ph.D., Executive Director of the Partnership to Fight Chronic ... the country will result in higher health care spending for states ...
... for the disparity need to be further explored, researchers ... without health insurance are more likely to die after ... who are insured, new research suggests. , "After ... outcomes based on insurance status," the study authors wrote. ...
... ... has been awarded this months "Editor,s Pick" by BrotherSoft in the prestigious business software ... ... desktop application has been awarded this months "Editor,s Pick" by BrotherSoft in the prestigious ...
... ... is emerging as the top business objective for employer-sponsored wellness programs around the world. ... New York ... emerging as the top business objective for employer-sponsored wellness programs around the ...
Cached Medicine News:Health News:NMB Motors Now In Stock at Newark 2Health News:U.S. National Library of Medicine Releases Draft SNOMED CT to ICD-9-CM Rules-Based Map to Support Reimbursement 2Health News:U.S. National Library of Medicine Releases Draft SNOMED CT to ICD-9-CM Rules-Based Map to Support Reimbursement 3Health News:U.S. National Library of Medicine Releases Draft SNOMED CT to ICD-9-CM Rules-Based Map to Support Reimbursement 4Health News:Obesity Rates Will Continue to Increase, Drive Health Care Costs in New Jersey in Next Decade, According to New Study 2Health News:Uninsured Trauma Patients More Likely to Die: Study 2Health News:Taskwise receives Editors Pick Award from BrotherSoft 2Health News:Taskwise receives Editors Pick Award from BrotherSoft 3Health News:Wellness Survey: Businesses Look to Wellness Programs to Improve Productivity and Lower Absenteeism Stress Cited as Top Health Risk Driving Wellness Programs Around the World 2Health News:Wellness Survey: Businesses Look to Wellness Programs to Improve Productivity and Lower Absenteeism Stress Cited as Top Health Risk Driving Wellness Programs Around the World 3Health News:Wellness Survey: Businesses Look to Wellness Programs to Improve Productivity and Lower Absenteeism Stress Cited as Top Health Risk Driving Wellness Programs Around the World 4Health News:Wellness Survey: Businesses Look to Wellness Programs to Improve Productivity and Lower Absenteeism Stress Cited as Top Health Risk Driving Wellness Programs Around the World 5Health News:Wellness Survey: Businesses Look to Wellness Programs to Improve Productivity and Lower Absenteeism Stress Cited as Top Health Risk Driving Wellness Programs Around the World 6
(Date:7/10/2014)... --  Ventana Medical Systems, Inc.  (Ventana), a member of ... an agreement with Merck KGaA, Darmstadt, Germany ... the United States and ... division on the development and commercialization of a companion ... diagnostic assays. In alignment with Merck KGaA,s strategic approach ...
(Date:7/10/2014)... , July 10, 2014   LabStyle Innovations ... Solution, today announced the appointment of Professor ... of its Board of Directors. Prof. ... business experience to LabStyle as an entrepreneur, venture ... and corporate governance expert. He currently serves on ...
(Date:7/10/2014)... 2014 Decision Resources Group finds that over ... Food and Drug Administration,s (FDA) approval of Vifor Fresenius ... was approved by the FDA in November 2013 for ... patients on dialysis. Other key findings from ... 2014 : , ...
Breaking Medicine Technology:Ventana Medical Systems, Inc. and Merck KGaA, Darmstadt, Germany to develop companion diagnostic test for cancer treatment 2Ventana Medical Systems, Inc. and Merck KGaA, Darmstadt, Germany to develop companion diagnostic test for cancer treatment 3LabStyle Innovations Welcomes Richard B. Stone to its Board of Directors 2LabStyle Innovations Welcomes Richard B. Stone to its Board of Directors 3LabStyle Innovations Welcomes Richard B. Stone to its Board of Directors 4Half of Surveyed Nephrologists Report Moderate Familiarity with Velphoro, Which Received FDA Approval Late Last Year for the Treatment of Hyperphosphatemia in Dialysis 2Half of Surveyed Nephrologists Report Moderate Familiarity with Velphoro, Which Received FDA Approval Late Last Year for the Treatment of Hyperphosphatemia in Dialysis 3
... ELx405 Series of microplate washers are precise, ... patented Dual-Action manifold, providing independent control of ... overfill washing and overflow protection in both ... Washer is the most precise and reliable ...
MW 96-W1 microplate washer with one wash line....
High precision microplate washer for immuno and adherent cell assays. For use with all strip types and full microplate in 96- and 384-well format in both portrait and landscape orientations....
Wellwash 384 is an efficient, rapid and reliable washing process for high-throughput screening. It has been designed to optimize the washing process and ensure the best results. Available in 384 or 9...
Medicine Products: