Navigation Links
Single gene defect causes brain tumor
Date:3/15/2011

Pilocytic astrocytoma, the most common brain tumor in children, is usually slow-growing and benign. However, surgeons often cannot completely remove the diffusely growing tumor. This means that patients need further treatment in order to destroy remaining tumor tissue. Chemotherapy or radiation therapy can lead to severe side-effects and have only little effect on these slowly growing tumors. Affected children therefore urgently need new, targeted therapies.

A typical genetic defect in these brain tumors is already known: "From our own research we know that there is a defect in the BRAF gene in the great majority of pilocytic astrocytomas," says Professor Dr. Peter Lichter of the German Cancer Research Center. This defect causes a cellular signaling pathway, which in healthy cells is active only in case of acute need, to be permanently activated.

Jan Gronych from Lichter's department has now studied, jointly with colleagues of Heidelberg University Hospitals, the actual relevance of the BRAF defect for carcinogenesis. To this end, the investigators packed a defective BRAF gene into a virus and thus introduced it into neuronal precursor cells of mice. In 91 percent of animals thus treated, tumors developed around the injection site. These tumors corresponded to pilocytic astrocytoma in terms of their biology, growth characteristics and tissue structure.

Cells of these tumors all showed the typical symptom of a defective BRAF gene: a permanently activated MAP kinase enzyme. "This proves that a single gene defect is really sufficient to cause pilocytic astrocytoma," said Lichter, summarizing the results.

A permanently active MAP kinase constantly transmits growth signals in cancer cells, while it is also their Achilles' heel: In recent years, a number of drugs have been developed which inhibit the enzyme activity of kinases very specifically and, thus, can impede cancer growth. The Heidelberg researchers have shown that brain cells which are driven to permanent abnormal cell division by a defective BRAF gene slowed down growth after treatment with kinase inhibitor sorafenib.

"Up to now, we did not have a suitable model system for testing newly developed drugs against pilocytic astrocytoma," says Peter Lichter. "The BRAF mice open up the possibility to test new kinase inhibitors or other drugs specifically for their effectiveness against pilocytic astrocytoma."


'/>"/>

Contact: Dr. Sibylle Kohlstdt
s.kohlstaedt@dkfz.de
Helmholtz Association of German Research Centres
Source:Eurekalert

Related medicine news :

1. See how they grow: Monitoring single bacteria without a microscope
2. Cancer in a single catastrophe
3. Scientists Aim for Test That Spots Single Cancer Cell in Blood Sample
4. Scientists Aim for Test That Could Spot Single Cancer Cell in Blood
5. Single Embryo Beat Double Embryo Transfer in IVF Study
6. New combo lung cancer therapy improves survival over single-line treatment
7. Lesbian, gay and bisexual teens singled out for punishment
8. Mutations in single gene predict poor outcomes in adult leukemia
9. New study singles out factors linked to cognitive deficits in type 2 diabetes
10. New diagnostic chip able to generate single-cell molecular fingerprints for brain tumors
11. Single Lung Tumor Contains 50,000 Mutations
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/17/2017)... ... January 17, 2017 , ... ... assistance to families and business professionals throughout central Colorado, is joining local nonprofit ... , The Aurora Warms The Night organization is committed to breaking the cycle ...
(Date:1/17/2017)... ... January 17, 2017 , ... Physicians Education ... Lee as keynote speaker for the 34th Annual Miami Breast Cancer Conference®, on ... announcement, PER® president, Phil Talamo, said, “We are delighted to have Sandra Lee ...
(Date:1/17/2017)... ... , ... Today, FloSports , a global leader in live digital sports ... of a long-term extension of their media partnership. The partnership, which began in 2013, ... sport’s premier events exclusively on FloWrestling.com as well as usage of the FloArena meet ...
(Date:1/16/2017)... ... January 16, 2017 , ... California Southern University has named Dr. Steven ... Board of Trustees and as a core faculty member, teaching master’s and doctoral courses ... of psychology at Pepperdine University, where he earned his Doctor of Psychology degree in ...
(Date:1/16/2017)... ... ... Anybody who may be looking for a substance abuse rehabilitation program with ... a holistic treatment center for addiction located in Marne, MI. This video, which can ... and staff that visited the 2016 Recovery Palooza support event in nearby Grand Rapids. ...
Breaking Medicine News(10 mins):
(Date:1/17/2017)... -- Interpace Diagnostics Group, Inc., (NASDAQ: IDXG ), ... and pathology services for evaluating risks of cancer, announced ... 13, 2017 from the NASDAQ Listing Qualifications notifying the ... of the NASDAQ Stock Market to maintain a minimum ... The letter noted that for the last 10 days ...
(Date:1/17/2017)... Research and Markets has announced the addition ... their offering. ... The global laparotomy sponges market to grow at a CAGR of ... Sponges Market 2016-2020, has been prepared based on an in-depth market ... landscape and its growth prospects over the coming years. The report ...
(Date:1/17/2017)... , Jan. 17, 2017 Tempus, ... cancer care, and University Hospitals Seidman Cancer Center ... by making genomic data, advanced molecular analysis and ... researchers, physicians and healthcare providers. ... provide genomic and transcriptomic sequencing and analysis for ...
Breaking Medicine Technology: