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Single-fraction RT as effective as multiple-fraction RT for palliation of bone metastases
Date:8/4/2014

ered independently for each course (patients could be counted more than once). Radiation therapy fractionation was divided into two categories: SFRT or MFRT. The most common primary disease site was breast (23.4 percent), and the most frequently treated bony metastatic site was the spine (42.2 percent).

SFRT was used to treat bone metastases in 49.2 percent (7,097) of the radiation therapy courses. SFRT was most commonly used to treat bone metastases that originated from hematological (56.6 percent) and prostate (56.1 percent) cancers; the most common bony metastatic sites treated with SFRT were the ribs (83 percent) and extremity (66.4 percent).

There was a significant variation in the use of SFRT by each of the five cancer centers operated by the BC Cancer Agency during the time of the study, with a range of 25.5 percent to 73.4 percent (p<.001). The study found that the overall utilization rate of SFRT in British Columbia is 49.2 percent, a rate consistent with other Canadian and European data that shows SFRT use ranges from 32 percent to 64 percent. SFRT use is much higher, however, than in the United States, where SFRT use ranges from only 3 percent to 13 percent.

"Previous research has shown that single-fraction radiation therapy is equally as effective as longer multiple-fraction courses. Single-fraction radiation therapy offers greater convenience for patients, is associated with fewer side effects and incurs a lower cost. Even a modest change in the frequency of single-fraction radiation therapy use, in Canada and America, could lead to meaningful cost-savings, improved patient convenience and reduced patient side effects, thereby increasing patients' quality of life," said Robert A. Olson, MD, MSc, lead author of the study, and the research and clinical trials lead and a radiation oncologist at the BC Cancer Agency Centre for the North. "As a result of discussing our study outcomes among radiation oncologists in British Columbi
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Contact: Michelle Kirkwood
press@astro.org
703-286-1600
American Society for Radiation Oncology
Source:Eurekalert

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