Navigation Links
Single-fraction RT as effective as multiple-fraction RT for palliation of bone metastases

Fairfax, Va., August 4, 2014Standardizing prescribing practices for single-fraction radiation therapy (SFRT) for palliation of bone metastases could lead to cost savings and improvement in patients' quality of life, according to a study published in the August 1, 2014 edition of the International Journal of Radiation Oncology Biology Physics (Red Journal), the official scientific journal of the American Society for Radiation Oncology (ASTRO).

Bone metastases are a common manifestation of distant spread of disease, occurring most frequently with prostate, breast and lung cancers. Of these patients, two-thirds develop bone metastases to the spine, pelvis or extremities. Radiation therapy is an effective form of palliative treatment for bone metastases. There are more than 25 randomized controlled trials demonstrating that SFRT provides the same amount of pain control as multiple-fraction radiation therapy (MFRT); however, there is low use internationally of SFRT for bone metastases.

"Use of Single- versus Multiple-Fraction Palliative Radiation Therapy for Bone Metastases: Population-Based Analysis of 16,898 Courses in a Canadian Province," is one of the largest, current studies on the use of SFRT. The study was designed to determine the use of SFRT in British Columbia, a publicly funded health care system where there is no financial incentive for extended fractionation and all radiation therapy is provided by the BC Cancer Agency with no direct cost to patients.

Patients who received palliative radiation therapy for bone metastases, regardless of the primary cancer site at diagnosis, from 2007 to 2011 were identified using the BC Cancer Agency's Cancer Agency Information System (CAIS). During the study period, 8,601 patients received 16,898 courses of radiation therapy. Patients who received re-irradiation for bone metastases were included, and patients who received more than one course of radiation therapy were considered independently for each course (patients could be counted more than once). Radiation therapy fractionation was divided into two categories: SFRT or MFRT. The most common primary disease site was breast (23.4 percent), and the most frequently treated bony metastatic site was the spine (42.2 percent).

SFRT was used to treat bone metastases in 49.2 percent (7,097) of the radiation therapy courses. SFRT was most commonly used to treat bone metastases that originated from hematological (56.6 percent) and prostate (56.1 percent) cancers; the most common bony metastatic sites treated with SFRT were the ribs (83 percent) and extremity (66.4 percent).

There was a significant variation in the use of SFRT by each of the five cancer centers operated by the BC Cancer Agency during the time of the study, with a range of 25.5 percent to 73.4 percent (p<.001). The study found that the overall utilization rate of SFRT in British Columbia is 49.2 percent, a rate consistent with other Canadian and European data that shows SFRT use ranges from 32 percent to 64 percent. SFRT use is much higher, however, than in the United States, where SFRT use ranges from only 3 percent to 13 percent.

"Previous research has shown that single-fraction radiation therapy is equally as effective as longer multiple-fraction courses. Single-fraction radiation therapy offers greater convenience for patients, is associated with fewer side effects and incurs a lower cost. Even a modest change in the frequency of single-fraction radiation therapy use, in Canada and America, could lead to meaningful cost-savings, improved patient convenience and reduced patient side effects, thereby increasing patients' quality of life," said Robert A. Olson, MD, MSc, lead author of the study, and the research and clinical trials lead and a radiation oncologist at the BC Cancer Agency Centre for the North. "As a result of discussing our study outcomes among radiation oncologists in British Columbia, we have already seen an increase in the use of single-fraction radiation therapy for bone metastases. We are hopeful that these results will motivate practice change worldwide."


Contact: Michelle Kirkwood
American Society for Radiation Oncology

Related medicine news :

1. Lung cancer diagnosis tool shown to be safe and effective for older patients
2. Transplantation shown to be highly effective in treating immune deficiency in children
3. Acne No More Review Reveals Most Effective Acne Cure Program
4. As Testosterone Lawsuits Mount, Bernstein Liebhard LLP Notes New Study Questioning Effectiveness of Low Testosterone Therapy in Diabetics
5. ProCare Protein Check Tests Surgical Instruments to Verify Effective Cleaning
6. Study Shows Nordic Naturals® Triglyceride-Form Ultimate Omega®/ProOmega® More Effective Than Krill Oil, Salmon Oil, and Ethyl Ester Fish Oil
7. Online information most cost-effective means of increasing MMR uptake, research finds
8. New Case Study Highlights Effectiveness of Testosterone Therapy in Fighting Weight Gain and Fatigue
9. Stratus Video Interpreting Predicts $1 Billion Market Shift to Video Remote Interpreting by 2016 as Court and Healthcare Systems Heed Cost-Effectiveness
10. Cystic Fibrosis Drug Combo May Be Less Effective Than Hoped
11. Low strength brain stimulation may be effective for depression
Post Your Comments:
(Date:11/24/2015)... , ... November 24, 2015 , ... Autism Speaks, the ... global movement driven by social media and the generosity of people around the world. ... their social media networks to give – and share the personal stories behind those ...
(Date:11/24/2015)... ... 24, 2015 , ... World Patent Marketing , a ... invention that revolutionizes the vending machine industry by providing healthy and fresh smoothies ... billion," says Scott Cooper, CEO and Creative Director of World Patent Marketing. "Shakes ...
(Date:11/24/2015)... Nashville, Tennessee (PRWEB) , ... November 24, 2015 , ... ... 2015-2016 Pharmacy Quality Trend Report . Throughout the past year there have been multiple ... more mature state. During this transition, PharmMD has enabled their customers and partners to ...
(Date:11/24/2015)... (PRWEB) , ... November 24, 2015 , ... Dehydration, defined ... much body water to perspiration in the hot sun, and heat stroke and death ... water advocate and radio host Sharon Kleyne. Every cell, system and structure requires water ...
(Date:11/24/2015)... ... November 24, 2015 , ... “I am so thrilled, as a newbie here, to leave a ... won a $7,500 School Lounge Makeover® from California Casualty . Stephanie is in her ... has a much longer tenure. , “This is such an amazing school and we deserve ...
Breaking Medicine News(10 mins):
(Date:11/24/2015)... The uptake of recently approved and pipeline premium products for Type 1 ... 2021, says GBI Research . --> ... Diabetes Mellitus (T1DM), will be a key driver of market growth to ... The uptake of recently approved and pipeline premium products for Type ... to 2021, says GBI Research . ...
(Date:11/24/2015)... PAUL, Minn. , Nov. 24, 2015  Enova ... with Novocam of Helsinki, Finland ... Both companies are at the cutting edge of medical ... Headlights in the United States ... dental cameras. Together, they provide the world,s most powerful ...
(Date:11/24/2015)...  BioPlast Manufacturing, a manufacturer of plastic components ... and biotech environments, announced today that it has ... dishes. This acquisition is aligned with BioPlast Manufacturing,s ... that are designed and tested by scientists for ... Bristol, Pennsylvania injection ...
Breaking Medicine Technology: