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Single enzyme is necessary for development of diabetes
Date:8/14/2014

l mice showed oxidative damage, demonstrating that 12-LO and the resulting HETEs caused the beta cell failure.

Mirmira notes that fatty diet used in the study was the Western Diet, which comprises mostly saturated"bad"fats. Based partly on a recent study of related metabolic pathways, he says that the unsaturated and mono-unsaturated fatswhich comprise most fats in the healthy, relatively high fat Mediterranean dietare unlikely to have the same effects.

"Our research is the first to show that 12-LO in the beta cell is the culprit in the development of pre-diabetes, following high fat diets," says Mirmira. "Our work also lends important credence to the notion that the beta cell is the primary defective cell in virtually all forms of diabetes and pre-diabetes."


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Contact: Jim Sliwa
jsliwa@asmusa.org
202-942-9297
American Society for Microbiology
Source:Eurekalert

Page: 1 2

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