Navigation Links
Single embryo transfer reduces the risk of perinatal mortality in IVF
Date:7/4/2012

Istanbul, 4 July 2012: A policy of single embryo transfer (SET) reduces the risk of perinatal mortality in infants born as a result of IVF and ICSI. The conclusion emerged from an analysis of more than 50,000 births recorded in the Australian and New Zealand Assisted Reproduction Technology Database between 2004 and 2008, where the introduction of an SET policy has been associated with a reduction in overall perinatal mortality for IVF and ICSI babies.

Results of the analysis were presented here today at the annual meeting of ESHRE (European Society of Human Reproduction and Embryology) by Professor Elizabeth Sullivan from the Perinatal & Reproductive Epidemiology Research Unit of the University of New South Wales in Sydney, Australia. Professor Sullivan said that from a public health perspective "there is justification for advocating SET as first line management in assisted reproduction with the aim of minimising preventable perinatal deaths".

The study she described included 50,258 births which were of more than 20 weeks gestation and/or 400 grams birthweight following IVF and ICSI pregnancies. Total perinatal deaths were defined as the number of fetal deaths (stillbirths) plus the number of neonatal deaths (deaths that occur before 28 days after birth).

Analysis showed an overall perinatal mortality rate of 16.2 per 1000 births, representing 813 perinatal deaths during the study period (630 stillbirths and 183 neonatal deaths).

However, births following the transfer of two embryos had a significantly higher perinatal mortality rate than births following SET (19.1 per 1000 births and 13.2 per 1000 births). The risk of perinatal mortality for all births following two embryo transfer was 53% higher than those following SET. This difference was especially apparent in births following the transfer of fresh (and not frozen) embryos; births following the transfer of two fresh embryos had 74% higher risk of perinatal mortality than births following fresh SET.

Twins accounted for half the total neonatal deaths and one-third the perinatal deaths. Twins also had significantly higher perinatal mortality rate than singletons (27.8 per 1000 births and 12.4 per 1000 births). However, twins born from SET (ie, monozygotic) had a higher risk of perinatal mortality than those born from two embryo transfers.

Professor Sullivan noted that the voluntary adoption of an IVF policy of single embryo transfer in Australia and New Zealand has been associated with a reduction in overall perinatal mortality for all babies conceived by assisted reproduction methods, which was justification in itself for recommending SET as a first line fertility treatment for non-donor cycles in women aged under 35 years.

Moreover, said Professor Sullivan, there are wider public health benefits from an SET policy. She explained: "The number of embryos transferred per procedure is the major determinant of multiple pregnancy and multiple delivery, which contribute to an elevated risk of preterm birth and low birth weight, and its sequelae. These are risks in addition to those already faced by women being treated for infertility.

"Australia and New Zealand have shown that in the right policy environment a voluntary change to SET practice is achievable," she added. The proportion of single embryo transfers in Australia/New Zealand IVF rose from 14.2% in 1999 to 67.8% in 2008, which was accompanied by a decline in multiple deliveries of 13.7 percentage points - from 22.1% in 2000 to 8.4% in 2008.

"In some other countries and regions," said Professor Sullivan, "the uptake of SET has been more dramatic, particularly where policy initiatives linked to funding have led to significant change in practice without compromising quality or safety."


'/>"/>

Contact: Christine Bauquis
christine@eshre.eu
32-499-258-046
European Society of Human Reproduction and Embryology
Source:Eurekalert

Related medicine news :

1. DeNova Homes at Southgate, Announces Single Story Model Opening
2. SingleSource Background Screening Company Calls On Adults To Take Proactive Approach To Stop Child Sexual Abuse
3. Study finds that single mothers can reduce stress by playing, engaging with children
4. The Convoy of Hope Rolls into Memphis Providing Some $1 Million in Goods and Services in a Single Day
5. Youngest hip and thigh fracture patients heal just fine with single-leg casts
6. Young Kids With Hip, Thigh Fractures Heal Well With Single-Leg Casts
7. Single Boomers Struggling as They Age: Study
8. Freezing all embryos in IVF with transfer in a later non-stimulated cycle may improve outcome
9. New embryonic stem cell line will aid research on nerve condition
10. Surgical sling reduces risk of weakened bladder control after prolapse surgery, U-M study says
11. Regional anesthesia reduces complications and death for hip fracture patients
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/4/2016)... ... May 04, 2016 , ... ... patented products, announces the Everlasting Glove, a sports invention that aids in the ... Sporting Goods Manufacturing industry is worth $9 billion," says Scott Cooper, CEO and ...
(Date:5/4/2016)... ... May 04, 2016 , ... Connor Sport ... surface for the 2016 NCAA Men’s National Collegiate Volleyball Championship. , ... volleyball championship to be held May 5-7 at Pennsylvania State University’s Rec Hall ...
(Date:5/4/2016)... ... May 04, 2016 , ... The Lymphoma ... innovative lymphoma research and serving the lymphoma community through a comprehensive series of ... the esteemed Quaker Ridge Golf Club in Scarsdale, New York on May 23, ...
(Date:5/4/2016)... ... May 04, 2016 , ... Nike Rugby Camp's success is due ... Diego. Willis, founder of Elite Rugby Camps and current Nike Camp director, has offered ... since 2009. , “I’m excited for our eighth summer here in San Diego,” ...
(Date:5/4/2016)... ... ... Wellness Center today announced its tenth anniversary of providing a complete approach to health ... to provide a holistic approach to wellness has now become a growing trend of ... Chiropractic Physician , the wellness center offers a complete range of services such as ...
Breaking Medicine News(10 mins):
(Date:5/3/2016)... May 3, 2016 ACME Markets, ... and Delaware County Councilman Dave ... Spray in all ACME pharmacies across ... Disease Control and Prevention (CDC), naloxone has saved 26,463 lives nationwide ... in Delaware County were authorized to administer ...
(Date:5/3/2016)... , May 3, 2016  While you may be familiar with watching a film or TV ... known as ultra-high-definition or 8MP in the Medical Industry.  Ampronix  is a renowned authorized reseller ... technology. Photo - http://photos.prnewswire.com/prnh/20160502/362730 ... ... ...
(Date:5/3/2016)...   Diplomat Pharmacy, Inc. (NYSE: DPLO) announced today that it is celebrating Hepatitis Awareness Month ... patients who tell their personal story and encourage those at risk to get tested and ... C ... ... Diplomat Specialty Pharmacy (PRNewsFoto/Diplomat Pharmacy, Inc.) ...
Breaking Medicine Technology: