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Single embryo transfer is the cheapest and most effective strategy for assisted reproduction
Date:3/24/2009

n-year period, 1,510 women younger than 40 were treated at the infertility unit at Oulu University Hospital. They had a total of 2,386 cycles when fresh embryos were transferred, followed by 1,272 cycles when frozen-thawed embryos were transferred (FET). About 90% of deliveries in both periods occurred within the first four treatment cycles, suggesting that the time to delivery with eSET is no longer than that for DET.

The researchers found there was a significant difference between the DET and eSET periods in terms of effectiveness and cost. The cumulative pregnancy rate and cumulative live birth rate per egg retrieval ("ovum pick-up") and the cumulative live birth rate per woman were all higher in the eSET period. Cumulative pregnancy rate per ovum pickup was 38.2% (eSET) versus 33.1% (DET), cumulative live birth rate per ovum pickup was 28% versus 22.5%, and cumulative live birth rate per woman was 41.7% versus 36.6%. In addition, the cumulative multiple birth rate was significantly lower in the eSET period (8.9% versus 19.6% in the DET period).

Dr Zdravka Veleva, from the same team, who is responsible for the economic analysis of the study, showed that the total treatment cost per woman in the eSET period was, on average, five per cent less than in the DET period (ranging from 2-20% less). In terms of euros, the total treatment cost per woman decreased by an average of 275 euros (ranging between 164-1184 euros) from the DET to the eSET period. When the researchers calculated the incremental cost-effectiveness ratio (ICER) [2] they found that 19,889 euros was saved per live baby born at term (after 37 weeks) in the eSET period compared with the DET period.

Dr Martikainen said: "There are few IVF centres in the world with greater experience than ours of eSET over such a long period of time. This study shows that the implementation of an eSET policy, together with an effective embryo freezing programme, results in a better outcome and l
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Contact: Emma Mason
wordmason@mac.com
44-771-129-6986
European Society for Human Reproduction and Embryology
Source:Eurekalert

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