Navigation Links
Single Lung Tumor Contains 50,000 Mutated Genes
Date:5/26/2010

Finding throws monkey wrench into idea of individualized therapies, experts say

WEDNESDAY, May 26 (HealthDay News) -- Malignant lung tumors may contain not one, not two, but potentially tens of thousands of genetic mutations which, together, contribute to the development of the cancer.

A sample from a lung tumor from a heavy smoker revealed 50,000 mutations, according to a report in the May 27 issue of Nature.

"People in the field have always known that we're going to end up having to deal with multiple mutations," said Dr. Hossein Borghaei, director of the Lung and Head and Neck Cancer Risk Assessment Program at Fox Chase Cancer Center in Philadelphia. "This tells us that we're not just dealing with one cell line that's gone crazy. We're dealing with multiple mutations. Every possible pathway that could possibly go wrong is probably found among all these mutations and changes."

The revelation does pose "additional difficulties" for researchers looking for targets for better treatments or even a cure for lung and other types of cancer, said study senior author Zemin Zhang, a senior scientist with Genentech Inc. in South San Francisco.

Frustrating though the findings may seem, the knowledge gleaned from this and other studies "gives investigators a starting point to go back and look and see if there is a common pathway, a common protein that a couple of different drugs could attack and perhaps slow the progression," Borghaei said.

The researchers examined cells from lung cancer samples (non-small-cell lung cancer) belonging to a 51-year-old man who had smoked 25 cigarettes a day for 15 years.

"If you look at the number of cigarettes this person has consumed over his lifetime versus the number of mutations accumulated, for every three cigarettes you have you get a new mutation," Zhang noted.

The researchers were initially surprised to hit upon so many genetic mutations -- some new and some previously known -- surprised enough to conduct additional analyses to validate the findings.

They found that many of the mutations were redundant, meaning that many of them affected components of the same pathway.

"The key to survival for cancer cells is redundancy: hit multiple pathways, mutate as much as you possibly can and then you can survive anything that comes at you," Borghaei explained.

The authors point out that this is one analysis from one patient. Other patients with lung cancer will have different mutational profiles, as will other tumor types.

And this particular tumor was smoking-related, with all of the damage conferred by cigarette carcinogens.

"In this particular case, it's smoking-related," Zhang said. "When you have a patient who has a long history of smoking, you can tell that most of the mutations are mediated by carcinogens, so we anticipate that we will observe a lot more mutations in such a [patient]."

The same is likely to be true of melanoma, because much of the damage here is caused by UV radiation, Zhang added, but the number of mutations in breast and prostate cancer, for instance, is likely to be much lower.

More information

The U.S. National Cancer Institute has more on lung cancer.



SOURCES: Zemin Zhang, Ph.D., senior scientist, Genentech Inc., South San Francisco; Hossein Borghaei, D.O., director, Lung and Head and Neck Cancer Risk Assessment Program, and assistant professor, Fox Chase Cancer Center, Philadelphia; May 27, 2010, Nature


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Cooking For Bachelors Seeks Singles Cooking For Love
2. SILS -- A New Houston Weight Loss Surgery -- Single Incision Laparoscopic Surgery
3. Wayne State Researchers Report a Possible Proofreading Step in DNA Synthesis by Observing Single Molecules of DNA Polymerase
4. Julian Lennon and James Scott Cook Release New Charity Single LUCY to Raise Awareness and Funds for Lupus Research
5. East Coast Fertility Aims to Build Families One Baby at a Time by Applying Single Embryo Transfers to Donor Egg Program
6. Single Shot of H1N1 Vaccine May Be Enough for Kids
7. Single gene mutation induces endometrial cancer
8. Bone-anchored hearing aids help youth with single-sided deafness
9. Device Helps Kids With Single-Sided Deafness
10. International Collaboration: FDA and European Medicines Agency Agree to Accept a Single Orphan Drug Designation Annual Report
11. Theory of single stem cell for blood components challenged
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... ... , ... On June 10-11, 2016, A Forever Recovery, a holistic treatment center ... Breakfast Table in Battle Creek, MI, where the rehabilitation facility is located. This annual ... the world’s leading providers of cereal and other breakfast foods. Its residents often refer ...
(Date:6/26/2016)... Charlotte, NC (PRWEB) , ... June 26, 2016 , ... Brent Kasmer, a legally blind ... able to be personalized through a fitness app. The fitness app plans to fix the ... solutions currently only offer a one size fits all type program , They ...
(Date:6/25/2016)... (PRWEB) , ... June 25, 2016 , ... Austin residents ... the American College of Mohs Surgery and to Dr. Russell Peckham for medical and ... highly effective treatment for skin cancer. The selective fellowship in Mohs Micrographic Surgery completed ...
(Date:6/25/2016)... ... June 25, 2016 , ... First Choice Emergency ... named Dr. Sesan Ogunleye, as the Medical Director of its new Mesquite-Samuell Farm facility. ... Director of our new Mesquite location,” said Dr. James M. Muzzarelli, Executive Medical Director ...
(Date:6/25/2016)... ... 25, 2016 , ... On Friday, June 10, Van Mitchell, Secretary of the ... to iHire in recognition of their exemplary accomplishments in worksite health promotion. , The ... Health & Wellness Symposium at the BWI Marriott in Linthicum Heights. iHire was one ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... Dublin ... of the " Global Markets for Spectroscopy Equipment" ... This report focuses on the global ... including its applications in various applications. The report deals ... three main industries: pharmaceutical and biotechnology, food and beverage, ...
(Date:6/24/2016)... -- The Academy of Managed Care Pharmacy (AMCP) today ... allow biopharmaceutical companies to more easily share health care ... coverage decisions, a move that addresses the growing need ... The recommendations address restrictions in the sharing of product ... a prohibition that hinders decision makers from accessing HCEI ...
(Date:6/24/2016)... and SAN CLEMENTE, Calif. , June 24, ... -based mobile pulmonary function testing company, is now able to perform ... developed by ndd Medical Technologies , Inc. ... in hospital-based labs.  Thanks to ndd,s EasyOne PRO ® , ARL ... can get any needed testing done in the comfort of her ...
Breaking Medicine Technology: