Navigation Links
Single Genetic Factor Key to Cardiovascular System
Date:4/8/2010

Finding could lead to treatment for heart failure, aortic aneurysm, researchers say

THURSDAY, April 8 (HealthDay News) -- Reduced levels or lack of a certain genetic factor are associated with heart failure and aortic aneurysm, say U.S. researchers.

This factor -- known as Kruppel-like Factor 15 (KLF15) -- protects the heart and aorta's ability to maintain structural and functional integrity. A team from Case Western Reserve University School of Medicine in Ohio found that patients with heart failure or aortic aneurysm had reduced levels of KLF15.

Research showed that the absence of the gene, combined with stress, was linked with both deadly conditions. Lab animals that lacked the gene were more likely to develop the cardiovascular diseases.

Further investigation revealed that KLF15 uses a common molecular mechanism to provide protective effects in the heart and aorta. Drugs that target this molecular pathway can be used to treat heart failure and aortic aneurysm, the researchers discovered.

An aortic aneurysm is a bulge in the aorta, the main artery that carries blood from the heart to the rest of the body. If the aneurysm bursts, death is possible.

The report is published in the April 7 online edition of the journal Science Translational Medicine.

"This is very rare to find a singular genetic factor that governs the response of the entire cardiovascular system. Our research proves that KLF15 governs the shared diseases of the heart and blood vessels," study senior author Dr. Mukesh K. Jain, director of the Case Cardiovascular Research Institute, said in a university news release.

The findings suggest that increasing the protective effects of KLF15 in the heart and aorta may prevent the start or progression of heart failure and aortic aneurysm, the researchers said.

More information

The U.S. National Heart, Lung, and Blood Institute has more about heart failure.



-- Robert Preidt



SOURCE: Case Western Reserve University, news release, April 7, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Cooking For Bachelors Seeks Singles Cooking For Love
2. SILS -- A New Houston Weight Loss Surgery -- Single Incision Laparoscopic Surgery
3. Wayne State Researchers Report a Possible Proofreading Step in DNA Synthesis by Observing Single Molecules of DNA Polymerase
4. Julian Lennon and James Scott Cook Release New Charity Single LUCY to Raise Awareness and Funds for Lupus Research
5. East Coast Fertility Aims to Build Families One Baby at a Time by Applying Single Embryo Transfers to Donor Egg Program
6. Single Shot of H1N1 Vaccine May Be Enough for Kids
7. Single gene mutation induces endometrial cancer
8. Bone-anchored hearing aids help youth with single-sided deafness
9. Device Helps Kids With Single-Sided Deafness
10. International Collaboration: FDA and European Medicines Agency Agree to Accept a Single Orphan Drug Designation Annual Report
11. Theory of single stem cell for blood components challenged
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2017)... ... 24, 2017 , ... “End Time GPS”: a dauntless and enlightened study ... Time GPS” is the creation of published author, Wesley Gerboth, a World War II ... and space-vehicle projects. Now, at age ninety-one, he shares the Wisdom God bestowed upon ...
(Date:3/24/2017)... ... , ... “The Communion of Saints: A Pastor’s Potpourri of ... across the United States. “The Communion of Saints” is the creation of ... congregations in seven states throughout his long career of devotion to the church. ...
(Date:3/23/2017)... ... March 23, 2017 , ... In 2016 the World ... that there could be four million Zika-related cases in the Americas within the next ... of US cases reported per year skyrocketing to an estimated 329,000. Yet, Zika, Lyme ...
(Date:3/23/2017)... , ... March 23, 2017 , ... The physicians of ... in the greater Houston Area. The new location is located at 2255 E. Mossy ... in Springwoods Village. This newest location will provide patients living in the north Houston ...
(Date:3/23/2017)... New Braunfels, TX (PRWEB) , ... March 23, 2017 , ... ... a new clinic, located at 960 Gruene Road in Building 2. The clinic is ... co-owner Dr. Andrew Bennett, PT, says opening the company’s second New Braunfels location brings ...
Breaking Medicine News(10 mins):
(Date:3/24/2017)... Research and Markets has announced the addition of the "Dental Implants ... ... for Dental Implants in US$ Million. The report provides separate comprehensive analytics ... , Europe , Asia-Pacific , ... Annual estimates and forecasts are provided for the period 2015 through 2022. ...
(Date:3/24/2017)... , March 24, 2017 FinancialBuzz.com News ... ... publisher of cannabis market research, the legal cannabis market is ... through 2021, despite conflicting signals from the current presidential administration. ... that the two biggest drivers of growth in this industry ...
(Date:3/24/2017)... Research and Markets has announced the addition of the "Deep ... to their offering. ... The Deep Learning: Drug Discovery and Diagnostics Market, 2017-2035 report examines ... deep learning solutions within the healthcare domain. Primarily driven by the ... solution to generate relevant insights from medical data. ...
Breaking Medicine Technology: