Navigation Links
Single Genetic Factor Key to Cardiovascular System
Date:4/8/2010

Finding could lead to treatment for heart failure, aortic aneurysm, researchers say

THURSDAY, April 8 (HealthDay News) -- Reduced levels or lack of a certain genetic factor are associated with heart failure and aortic aneurysm, say U.S. researchers.

This factor -- known as Kruppel-like Factor 15 (KLF15) -- protects the heart and aorta's ability to maintain structural and functional integrity. A team from Case Western Reserve University School of Medicine in Ohio found that patients with heart failure or aortic aneurysm had reduced levels of KLF15.

Research showed that the absence of the gene, combined with stress, was linked with both deadly conditions. Lab animals that lacked the gene were more likely to develop the cardiovascular diseases.

Further investigation revealed that KLF15 uses a common molecular mechanism to provide protective effects in the heart and aorta. Drugs that target this molecular pathway can be used to treat heart failure and aortic aneurysm, the researchers discovered.

An aortic aneurysm is a bulge in the aorta, the main artery that carries blood from the heart to the rest of the body. If the aneurysm bursts, death is possible.

The report is published in the April 7 online edition of the journal Science Translational Medicine.

"This is very rare to find a singular genetic factor that governs the response of the entire cardiovascular system. Our research proves that KLF15 governs the shared diseases of the heart and blood vessels," study senior author Dr. Mukesh K. Jain, director of the Case Cardiovascular Research Institute, said in a university news release.

The findings suggest that increasing the protective effects of KLF15 in the heart and aorta may prevent the start or progression of heart failure and aortic aneurysm, the researchers said.

More information

The U.S. National Heart, Lung, and Blood Institute has more about heart failure.



-- Robert Preidt



SOURCE: Case Western Reserve University, news release, April 7, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Cooking For Bachelors Seeks Singles Cooking For Love
2. SILS -- A New Houston Weight Loss Surgery -- Single Incision Laparoscopic Surgery
3. Wayne State Researchers Report a Possible Proofreading Step in DNA Synthesis by Observing Single Molecules of DNA Polymerase
4. Julian Lennon and James Scott Cook Release New Charity Single LUCY to Raise Awareness and Funds for Lupus Research
5. East Coast Fertility Aims to Build Families One Baby at a Time by Applying Single Embryo Transfers to Donor Egg Program
6. Single Shot of H1N1 Vaccine May Be Enough for Kids
7. Single gene mutation induces endometrial cancer
8. Bone-anchored hearing aids help youth with single-sided deafness
9. Device Helps Kids With Single-Sided Deafness
10. International Collaboration: FDA and European Medicines Agency Agree to Accept a Single Orphan Drug Designation Annual Report
11. Theory of single stem cell for blood components challenged
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/24/2016)... ... ... in a crisis. Her son James, eight, was out of control. Prone to extreme mood ... something upset him, he couldn’t control his emotions,” remembers Marcy. “If there was a ... children and say he was going to kill them. If we were driving on ...
(Date:6/24/2016)... ... June 24, 2016 , ... Comfort Keepers® of San Diego, CA is excited ... To Recovery® program to drive cancer patients to and from their cancer treatments. ... highest quality of life and ongoing independence. Getting to and from medical treatments ...
(Date:6/24/2016)... York, NY (PRWEB) , ... June 24, 2016 ... ... publication Haute Living, is proud to recognize Dr. Barry M. Weintraub as a ... that “the most beautiful women in the world, and the most handsome men, ...
(Date:6/24/2016)... D.C. (PRWEB) , ... June 24, 2016 , ... ... Heroes Golf Classic Tournament held on June 20th at the Woodmont Country Club ... charity, Luke’s Wings, an organization dedicated to helping service members that have been wounded ...
(Date:6/24/2016)... , ... June 24, 2016 , ... ... management skills and infrastructure. Most providers, however, are unsure how to move forward, ... Ascend to define a path forward tailored to an organization’s specific needs. ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... June 24, 2016  Arkis BioSciences, a leading ... and more durable cerebrospinal fluid treatments, today announced ... Series-A funding is led by Innova Memphis, followed ... other private investors.  Arkis, new financing will accelerate ... the market release of its in-licensed Endexo® technology. ...
(Date:6/23/2016)... Research and Markets has announced the addition ... Chemical (Sugar, Petrochemical, Glycerin), Inorganic Chemical), Functionality (Filler, Binder, ... Forecast to 2021" report to their offering. ... excipients market is projected to reach USD 8.1 Billion ... forecast period 2016 to 2021. The ...
(Date:6/23/2016)... Capricor Therapeutics, Inc. ... company focused on the discovery, development and commercialization ... in its ongoing randomized HOPE-Duchenne clinical trial (Halt ... its 24-patient target. Capricor expects the trial to ... 2016, and to report top line data from ...
Breaking Medicine Technology: