Navigation Links
Singapore scientists discover how to control fate of stem cells
Date:6/24/2011

Scientists from the Genome Institute of Singapore (GIS), an institute of the Agency for Science, Technology and Research (A*STAR), in collaboration with the Cancer Science Institute of Singapore (CSI), have discovered how the body uses a single communication system to decide the fate of stem cells. The study, published in the scientific journal PLoS Genetics on 23rd June 2011, paves the way for the development of new methods of stem cell therapy with fewer side effects.

Dr Kian Leong Lee and his team of scientists studied how a single signaling system known as the Nodal/Activin pathway tells stem cells what cell type they should eventually become. The pathway is able to specify a wide range of eventual cell types, challenging the current belief that chemical signaling systems are highly specific and only control a limited number of outcomes. This discovery is a major step forward for stem cell therapies and personalised medicine; by exploiting this signaling system, scientists will be able to control the eventual fate of a stem cell by simply adjusting the chemical environment of a cell. This method of controlling stem cell differentiation also avoids modifying the genetic material of the cell, a procedure that might lead to the cells becoming cancerous.

Dr Lee, first author and post-doctoral research fellow at GIS and CSI said, "Many scientists believe that protein and chemical signaling systems have highly specific functions in biology. However, our study demonstrates that the same type of signal can be changed very dramatically to give different instructions. This finding is extremely significant because it paves the way for advanced studies in cell regeneration and tissue repair, which could ultimately lead to its use in personalized medicine, where stem cells from the same patient could be manipulated to make other types of cells that are genetically matched to the donor."

Urban Lendahl, professor of genetics and vice-chairman at the Department of Cell and Molecular Biology at the Karolinska Institutet, Sweden mentioned, "The report by Lee et al represents a truly significant advance in our understanding of how one of the key signaling mechanisms controls stem cell maintenance and differentiation. The authors show that either an increase or decrease in Nodal/Activin signaling leads to exit from the stem cell state in embryonic stem cells. They also take this a step further, by providing a very exciting molecular explanation for this observation. The finding that pSmad2 regulates distinct gene sets at different levels of Nodal/Activin signaling provides new and important insights into the molecular regulation of the stem cell state."


'/>"/>

Contact: Winnie Serah Lim
656-808-8013
Agency for Science, Technology and Research (A*STAR), Singapore
Source:Eurekalert

Related medicine news :

1. Reliv International Introduces GlucAffect(R) in the Philippines, Malaysia and Singapore
2. Singapore Performs Cutting-edge Eye Surgeries
3. Singapore Offers New Hope to Cancer Patients
4. Singapore Dentistry Goes High Tech
5. Singapore Performs Asia's First Combined Heart and Liver Transplant
6. Singapore Embraces Minimally Invasive Spinal Surgery
7. Singapore's Gynaecologists Break New Grounds
8. Hebrew University added to Singapore research program
9. Less than 1 month until start of major osteoporosis meeting in Singapore
10. Scientists Pinpoint Area of Brain That Fears Losing Money
11. Scientists Discover How HIV Is Transmitted Between Men
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2017)... ... March 24, 2017 , ... “Finding Christ Through Social Media: ... journal chronicling the writer’s path toward true communion with God. “Finding Christ Through ... is the creation of published author Lea Michelle Johnson, a follower of Christ, ...
(Date:3/24/2017)... (PRWEB) , ... March 24, 2017 , ... ... collection of inspiring stories about real people of God in congregations across the ... John Miller, a Presbyterian minister ordained in 1964 who has served congregations in ...
(Date:3/23/2017)... ... 2017 , ... A recent report from the National Council on Teacher Quality ... report suggests, based on a review of GPA and SAT/ACT requirements at 221 institutions ... U.S. It argues that this higher bar should be set by states, by the ...
(Date:3/23/2017)... New Braunfels, TX (PRWEB) , ... March 23, 2017 , ... ... a new clinic, located at 960 Gruene Road in Building 2. The clinic is ... co-owner Dr. Andrew Bennett, PT, says opening the company’s second New Braunfels location brings ...
(Date:3/23/2017)... ... 23, 2017 , ... The MBI “Hall of Fame” recognizes the contributions of those whose careers ... impact on the careers of all others involved. , On Monday, March 21st, ... MBI’s Hall of Fame. The induction took place during the World of Modular – ...
Breaking Medicine News(10 mins):
(Date:3/24/2017)... , Mar. 24, 2017 Research and Markets has ... Analysis, 2016" report to their offering. ... The IPF pipeline is very strong with a total ... & Co., Inc., Biogen and Sanofi are involved in the development of ... which one is in Phase III stage, 15 are in Phase II ...
(Date:3/24/2017)... YORK , March 24, 2017 ... and Equipment stocks, which are: Neovasc Inc. (NASDAQ: NVCN), Hologic ... Heart Inc. (NASDAQ: SSH ). These companies are ... its prior gains on Thursday, March 23 rd , 2017, ... afternoon, while shares of health care companies in the S&P ...
(Date:3/24/2017)... surveys with 9,250 insured consumers fielded from February 2015 ... help from their plans in five key areas: 1) ... help closing gaps in care, 3) better digital connections, ... real-time guidance. Meeting these needs is essential to promoting ... A Reason to Stay Engaged in Health ...
Breaking Medicine Technology: