Navigation Links
Singapore scientists discover how to control fate of stem cells
Date:6/24/2011

Scientists from the Genome Institute of Singapore (GIS), an institute of the Agency for Science, Technology and Research (A*STAR), in collaboration with the Cancer Science Institute of Singapore (CSI), have discovered how the body uses a single communication system to decide the fate of stem cells. The study, published in the scientific journal PLoS Genetics on 23rd June 2011, paves the way for the development of new methods of stem cell therapy with fewer side effects.

Dr Kian Leong Lee and his team of scientists studied how a single signaling system known as the Nodal/Activin pathway tells stem cells what cell type they should eventually become. The pathway is able to specify a wide range of eventual cell types, challenging the current belief that chemical signaling systems are highly specific and only control a limited number of outcomes. This discovery is a major step forward for stem cell therapies and personalised medicine; by exploiting this signaling system, scientists will be able to control the eventual fate of a stem cell by simply adjusting the chemical environment of a cell. This method of controlling stem cell differentiation also avoids modifying the genetic material of the cell, a procedure that might lead to the cells becoming cancerous.

Dr Lee, first author and post-doctoral research fellow at GIS and CSI said, "Many scientists believe that protein and chemical signaling systems have highly specific functions in biology. However, our study demonstrates that the same type of signal can be changed very dramatically to give different instructions. This finding is extremely significant because it paves the way for advanced studies in cell regeneration and tissue repair, which could ultimately lead to its use in personalized medicine, where stem cells from the same patient could be manipulated to make other types of cells that are genetically matched to the donor."

Urban Lendahl, professor of genetics and vice-chairman at the Department of Cell and Molecular Biology at the Karolinska Institutet, Sweden mentioned, "The report by Lee et al represents a truly significant advance in our understanding of how one of the key signaling mechanisms controls stem cell maintenance and differentiation. The authors show that either an increase or decrease in Nodal/Activin signaling leads to exit from the stem cell state in embryonic stem cells. They also take this a step further, by providing a very exciting molecular explanation for this observation. The finding that pSmad2 regulates distinct gene sets at different levels of Nodal/Activin signaling provides new and important insights into the molecular regulation of the stem cell state."


'/>"/>

Contact: Winnie Serah Lim
656-808-8013
Agency for Science, Technology and Research (A*STAR), Singapore
Source:Eurekalert

Related medicine news :

1. Reliv International Introduces GlucAffect(R) in the Philippines, Malaysia and Singapore
2. Singapore Performs Cutting-edge Eye Surgeries
3. Singapore Offers New Hope to Cancer Patients
4. Singapore Dentistry Goes High Tech
5. Singapore Performs Asia's First Combined Heart and Liver Transplant
6. Singapore Embraces Minimally Invasive Spinal Surgery
7. Singapore's Gynaecologists Break New Grounds
8. Hebrew University added to Singapore research program
9. Less than 1 month until start of major osteoporosis meeting in Singapore
10. Scientists Pinpoint Area of Brain That Fears Losing Money
11. Scientists Discover How HIV Is Transmitted Between Men
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/5/2016)... ... February 05, 2016 , ... Give To Cure ... search for and donate to Give To Cure’s campaign that is crowdfunding clinical trials ... users make and share payments through a smart device. In 2015 alone, Venmo processed ...
(Date:2/5/2016)... ... February 05, 2016 , ... Pivot Point ... Best in KLAS: Software & Services for HIT Implementation Support & Staffing report ... independently ranks vendor performance by healthcare executives, managers and clinicians representing over 4,500 ...
(Date:2/5/2016)... ... February 05, 2016 , ... Dr. Justin Scott and Dr. ... Annual No Cost Dental Day to individuals in need. The event is scheduled to ... No Cost Dental Day is to provide dental care to community members in need. ...
(Date:2/5/2016)... ... February 05, 2016 , ... Dr. Ben Amini, a ... is now welcoming orthodontist, Dr. Amanda Cheng, to the practice. With the addition ... health care, including general dentistry, cosmetic treatments, periodontics, implant dentistry , endodontics, ...
(Date:2/5/2016)... ... February 05, 2016 , ... In sleep, when the ... a dream. A hallmark feature of patients with eating disorders is significant self-criticism, and ... disorder behaviors and obsessions are regarded as maladaptive means for coping with this unease, ...
Breaking Medicine News(10 mins):
(Date:2/5/2016)...  Venice,s newest laser clinic, Physicians Advanced ... kind in the area and specializes in the ... The physician-owned and operated laser clinic is taking ... with its revitalizing skin care approach, unprecedented eVisit ... technology. http://photos.prnewswire.com/prnh/20160204/329957 --> ...
(Date:2/5/2016)... , Feb. 5, 2016  Henry Schein, Inc. (NASDAQ: ... care products and services to office-based dental, animal health ... into an agreement to acquire a majority ownership interest ... and equipment in Brazil . ... in Blumenau, Brazil, Dental Cremer is the dental distribution business ...
(Date:2/4/2016)... Feb. 4, 2016  Edwards Lifesciences Corporation (NYSE: ... structural heart disease and critical care monitoring, announced today ... (ASR) agreement with Morgan Stanley & Co. LLC to ... is part of the Company,s previously authorized program to ... stock.  --> --> ...
Breaking Medicine Technology: