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Singapore clinician-scientists identify new type of deadly lymphoma
Date:4/1/2013

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In addition, the team has identified a novel biomarker, known as MATK (megakaryocyte-associated tyrosine kinase), and developed a diagnostic test that enables clinicians to accurately diagnose patients suffering from this type of lymphoma. Requests for this test have come in from around the world, including China and the U.S.

"Our research has an immediate impact on the care we can provide to patients with this rare but very aggressive intestinal lymphoma," said Associate Prof Lim Soon Thye, Deputy Head and Senior Consultant, Department of Medical Oncology, NCCS, and Associate Professor at Duke-NUS. "With an accurate diagnosis, we can treat our patients better and improve overall survival." The average overall survival observed by the researchers was only seven months.

The study is a testimony to the close collaboration between scientists, pathologists and clinicians in the Singapore Lymphoma Study Group and investigators from across the region. "It underscores the importance of working with a multidisciplinary team across institutions and countries to address gaps in research in Asia," added Assoc Prof Lim, who is the senior author of the study.

Expanding on the benefit of a multi-disciplinary approach, Professor Teh Bin Tean, Professor at NCCS and Duke-NUS, said: "One of the advantages of pursuing academic medicine is that we can approach questions seen at the bedside from all angles, avoiding a silo approach. And once we have results, the different team members bring this knowledge back to their different specialties to develop diagnostic kits, identify potential drug candidates or to implement changes to clinical practice."

Next, the researchers plan to collaborate with international experts in the United States and Canada to investigate the cell of origin and explore immunological approaches to block its growth.


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Contact: Lydia Ng
lydia.ng.w.r@singhealth.com.sg
659-271-6175
SingHealth
Source:Eurekalert

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