Navigation Links
Simvastatin Leads Pfizer's Lipitor in Second-Line Patient Share for the Treatment of Dyslipidemia
Date:5/13/2008

Results from the ENHANCE Trial Impacting Physician Prescribing Patterns,

According to a New Report from Decision Resources

WALTHAM, Mass., May 13 /PRNewswire/ -- Decision Resources, one of the world's leading research and advisory firms for pharmaceutical and healthcare issues, finds that simvastatin (Merck's Zocor, generics) leads Pfizer's Lipitor in second-line patient share -- 22.9 percent versus 14.7 percent. Most patients progressing to simvastatin do so after switching from Lipitor. Surveyed primary care physicians and cardiologists cite simvastatin's better reimbursement and formulary status as the primary reason to prescribe simvastatin instead of Lipitor. Nevertheless, despite the availability of generic statins, more than 75 percent of Lipitor's prescriptions stem from first-line therapy.

The report entitled Treatment Algorithms in Dyslipidemia also finds that, prior to the release of the ENHANCE trial results, Merck/Schering-Plough's Vytorin and AstraZeneca's Crestor also gained significant second-line patient shares-13.1 percent and 10.9 percent, respectively. These gains reflect physicians' efforts to boost efficacy in patients whose initial low-density lipoprotein (LDL) lowering treatment had been less than optimal; surveyed physicians perceive these agents to offer the best LDL-reducing ability. However, 47 percent of surveyed primary care physicians and 49 percent of surveyed cardiologists have changed their prescribing of Merck/Schering- Plough's Zetia and Vytorin because of data from the ENHANCE trial, which showed that the addition of Zetia to simvastatin treatment did not significantly change carotid artery thickness. The majority of surveyed physicians now prescribe Vytorin and Zetia in fewer new patients, with a smaller percentage of physicians switching patients off of these drugs.

"Cardiologists we surveyed expect to decrease their first- and second-line prescriptions for Vytorin between 2008 and 2010, and to increase their third- line use of the drug in the same time period." said Madhuri Borde, Ph.D., analyst at Decision Resources. "However, fewer surveyed primary care physicians anticipate lower use of Vytorin in first- and second-line therapy over the next two years."

About Treatment Algorithm Insight Series

Decision Resources combines in-depth primary research with the most extensive claims-based longitudinal patient-level data from PharMetrics(R) to provide exceptional insight into physicians' prescribing trends and the factors that drive therapy product choice, from diagnosis through multiple courses of treatment, for a specific disease.

For each disease examined, Decision Resources' Treatment Algorithm Insight Series provide the following:

-- Summary of U.S. medical practice based on interviews with leading

experts in the field.

-- Qualitative diagnosis/referral/treatment algorithm for the United

States.

-- Drug usage by lines of therapy (1st, 2nd, 3rd line).

-- Discussion of key freeform combinations by lines of therapy.

-- Product share (class and specific compound level) within each line of

therapy (1st, 2nd, 3rd line).

-- Progression of therapy from key 1st line products.

-- Pathway to key therapies from previous therapies.

-- Qualitative analysis of two-year forecast incorporating upcoming

launches, changes in reimbursement, etc.

About Decision Resources

Decision Resources (http://www.DecisionResources.com) is a world leader in market research publications, advisory services, and consulting designed to help clients shape strategy, allocate resources, and master their chosen markets. Decision Resources is a Decision Resources, Inc. company.

All company, brand, or product names contained in this document may be trademarks or registered trademarks of their respective holders.

For more information, contact:

Elizabeth Marshall

Decision Resources

781-296-2563

emarshall@dresources.com


'/>"/>
SOURCE Decision Resources
Copyright©2008 PR Newswire.
All rights reserved

Related medicine news :

1. Abbotts Investigational SIMCOR(R) Offers Comparable LDL Lowering to Simvastatin and Significantly Raises HDL and Lowers Triglycerides in Phase III Study
2. Nursing professor leads the way for telepsychiatry by nurses to treat postpartum depression
3. Prisoner HIV program leads to continuum of medical care after release
4. Osteotech Announces the Unexpected Passing of Audit Committee Member Leads to Receipt of Nasdaq Deficiency Letter
5. Minimally invasive pancreas surgery leads to fewer complications, study finds
6. UQ leads the way on complementary medicine research
7. Prostate cancer screening program leads to bigger fall in death rates than surrounding areas
8. When positive thinking leads to financial irresponsibility like compulsive gambling
9. Drug compound leads to death of ovarian cancer cells resistant to chemotherapy
10. Eli Manning Leads March for Babies in Manhattan
11. MRI before surgery leads to better-adapted treatment for breast cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/26/2017)... ... ... in the Garden of Eden”: retells the stories of three Bible figures in modern terms. ... Penelope Colt, mother, trader, horse farmer, artist and a former GM journeyman. Born in ... six, they moved to Dayton, Ohio, where Penny graduated high school. At sixteen, she ...
(Date:5/24/2017)... ... 24, 2017 , ... Dr. Alan I. Benvenisty, MD is dual board certified ... is known for his distinguished expertise and experience in the diagnosis and treatment of ... in treating renovascular disease and aortic aneurysm . He is known for his ...
(Date:5/24/2017)... Cortland, OH (PRWEB) , ... May 24, 2017 , ... ... in Cortland, OH, can now meet with Dr. Joseph Bedich for a consultation, ... smiles while simultaneously improving their oral health and functionality. , Dr. Bedich ...
(Date:5/24/2017)... ... May 24, 2017 , ... Medic CE , a ... Truth about Pediatric Septic Shock” hosted by the Journal of Emergency Medical Services (JEMS). ... Eastern time, will be presented by Captain Rommie Duckworth, LP, a career fire captain ...
(Date:5/24/2017)... , ... May 24, 2017 , ... ... prominent for-profit and nonprofit hospitals and health systems in the nation and help ... their institutions, led professional organizations and been instrumental in developing successful hospital and ...
Breaking Medicine News(10 mins):
(Date:5/22/2017)... Fla. , May 22, 2017  As ... as a whole continue to make the revolutionary ... becomes increasingly important for ensuring positive patient outcomes ... industry stakeholders are shifting focus away from clinical ... and effects of long-term specialty drug therapy utilization ...
(Date:5/18/2017)... N.J. , May 17, 2017  Bayer announced ... oncology portfolio will be presented at the 53 rd ... Oncology (ASCO), taking place June 2-6 in ... presented at ASCO span prostate, colorectal, liver and thyroid ... analysis from the Phase II CHRONOS-1 trial of copanlisib ...
(Date:5/15/2017)... Enterin Inc., a privately-held CNS pharmaceutical company based in ... Parkinson,s disease (PD), has enrolled the first patient in the ... multicenter study involving patients with PD and taking place at ... 9-to-12-month period. The first stage is open label and involves ... include Denver , Boca Raton ...
Breaking Medicine Technology: