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Simpler and cheaper antibiotic prophylaxis with insertion of nutrition catheter in the stomach
Date:7/2/2010

Researchers at Karolinska Institutet recommends a new routine for protection against infection when percutaneous endoscopic gastrostomy (PEG), a tube for feeding directly through the abdominal wall, is surgically inserted in the stomach. The new routine is both simpler and cheaper than the one used today. The method, presented in the British Medical Journal, has been clinically tested on over 200 patients at the Karolinska University Hospital in Solna, Stockholm County, Sweden.

PEG is typically used for patients unable to swallow and eat in the usual way, and used when improvement in the short term is not expected, for example, in case the patient has throat cancer, esophagus cancer or got a stroke. In Sweden there are several thousand PEG operations per year, and surgery is increasing. One problem with surgery is that the risk of infection is high, which at worst can lead to death. To reduce the risk of infection, cefuroxime, a type of liquid antibiotics for use directly in the blood stream is given today, one hour before surgery.

"It is always difficult for the operating doctor to know whether the infection preventive treatment has been given on time, which could stop the whole operation process", says Dr John Blomberg, PhD Student at Karolinska Institutet and Senior Physician at Karolinska University Hospital.

"In some cases, it is impossible to insert a PEG and then the antibiotics have been given unnecessarily. When a PEG operation fails, which occurs in every ten cases, it usually depends on how the internal organs are located in relation to the abdominal wall and stomach", Dr Blomberg continues.

With the new method for protection against infection, which he and his colleagues present in the scientific journal BMJ, the patient is instead given different antibiotic drugs, a combination of sulfamethoxazole and trimethoprim, as a direct solution in PEG-catheter after surgery is completed. This routine in combinati
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Karolinska Institutet
Source:Eurekalert

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