Navigation Links
Simple test accurately predicts risk of serious jaundice in newborns
Date:1/10/2008

Philadelphia, Pa., Jan. 10, 2008 A simple test can accurately identify which newborn babies are at risk for developing dangerous levels of jaundice, according to researchers at The Childrens Hospital of Philadelphia.

While neonatal jaundice, a yellowing of the skin caused by a buildup of a blood product called bilirubin, is common in newborns and usually disappears on its own, it can progress to brain damage in a small fraction of cases.

The American Academy of Pediatrics currently recommends two options, used alone or in combination, to assess an infants risk of developing severe hyperbilirubinemia: a predischarge measurement of the bilirubin level and a screening checklist of risk factors such as intended method of feeding, siblings with history of jaundice, and race.

The Children's Hospital researchers say that the predischarge bilirubin measurement, combined with the baby's gestational age, is the most accurate method for predicting whether the newborn is at risk.

Their findings are published in the January 2008 issue of the journal Pediatrics. Childrens Hospital physicians studied outcomes for 823 newborns admitted to the Hospital of the University of Pennsylvania in Philadelphia between September 2004 and October 2005.

The challenge facing every pediatrician who takes care of newborn babies is to identify those infants they send home that will develop a bilirubin level that could cause injury, said Ron Keren, M.D., M.P.H., a pediatrician at Childrens Hospital and the lead author of the study. We found that by measuring the bilirubin in every baby, and combining that information with the babys gestational age, you could accurately predict which infants are at very high risk and which ones are at very low risk.

This screening method should allow pediatricians to determine which newborns should stay in the hospital for monitoring, which may go home and return the next day for another test and which dont need any additional follow-up for jaundice. About 70 percent of babies fell into the low-risk category, while 13 percent were designated high risk and 17 percent were in the middle, said Keren.

It did a nice job of pulling out a very large group of babies you dont have to worry about and a small group of babies that need to be closely followed, Keren said.

About four million babies are born in the U.S. each year. Of those, about 60 percent will develop jaundice in the first few days of life, but only about 1 in 100,000 will develop bilirubin levels that cause brain damage, known as kernicterus.

The authors caution that the study has a few limitations, including a small sample size. Some infants in the study were treated with phototherapy, high levels of colored light used to break down the bilirubin, before meeting the criteria. Finally, about half of the study participants were born to black mothers and the researchers data indicates black infants are less prone to develop significant hyperbilirubinemia.

More research on risk-assessment strategies is needed to weigh the cost of implementing a universal program and its effectiveness for preventing severe hyperbilirubinemia against false test results, unnecessary testing and treatment, and delay in hospital discharge, said Keren.


'/>"/>

Contact: Juliann Walsh
walshj1@email.chop.edu
267-426-6054
Children's Hospital of Philadelphia
Source:Eurekalert

Related medicine news :

1. Ring In 2008 With Simple New Years Resolutions That Will Stick Year-Round
2. Simple strategy could prevent half of deadly tuberculosis infections
3. be(R) is Making Health Simple With Complimentary, Expert Online Diet, Nutrition and Exercise Advice
4. YMCA of the USA Offers Simple Tips to Give the Lifetime Gift of Health and Well-Being to Family and Friends This Holiday Season
5. Simple Tips Keep the Flu at Bay
6. LA BioMed research finds simpler way to assess breast cancer risk
7. Six Simple Steps to Protect Against and Stop the Spread of Superbugs
8. Simpler Anemia Treatment May Help Kidney Patients
9. Simplex Diabetic Supply, Inc. Secures $50 Million in Growth Equity from New Enterprise Associates
10. AUDIO from Medialink and Bayer: Simple, Focused Ways to Boost Womens Health
11. Simple, personalized interventions improve colorectal cancer screening rates
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/6/2016)... ... February 06, 2016 , ... With the FCPX LUT: Summer ... to their footage. A LUT is a Lookup Table that contains a mathematical formula ... indicated by the table. By manipulating each pixel, LUT's can change each color range ...
(Date:2/6/2016)... , ... February 06, 2016 , ... ... of eating disorder treatment helps to reduce the frequency and level of relapse. ... Recovery Phase: Re-Establishing Healthy Identity and Purpose,” will explore the critical tasks of ...
(Date:2/5/2016)... ... , ... Love is in the air at King Kullen! The local grocer ... This staple for Valentine’s Day is a must-have, and can be picked up with ... only are long-stem roses available, but also other flower bouquets, elegantly wrapped and ready ...
(Date:2/5/2016)... ... February 05, 2016 , ... Today, the Whole-Food Warrior ... that the much-anticipated feature with author Jahnavi Foster, specialist in healthy vegetarian cuisine, will ... , Each week, on his weekly Whole-Food Warrior TV show, Frank Davis highlights Whole-Food ...
(Date:2/5/2016)... ... 05, 2016 , ... The event is being held on April 7, 2016 ... Minn. Triumph Over Parkinson’s will fund nearly $100,000 for research for the care and ... Parkinson’s disease and is the architect of this informative event to raise awareness and ...
Breaking Medicine News(10 mins):
(Date:2/4/2016)... 2016  The Senior Care Pharmacy Coalition (SCPC) ... Chairman Jason Chaffetz (R-UT) and Ranking ... hearing , "Developments in the Prescription Drug Market," ... questions about abusive pharmacy benefit manager (PBM) pricing ... Ranking Member Elijah Cummings (D-MD) are diligent, serious ...
(Date:2/4/2016)... , Feb. 4, 2016  Montoya Love is recognized ... the field of Pharmaceuticals. Montoya is the Regulatory Systems ... Manufacturing and selling ... Becton Dickinson provides healthcare institutions, clinical laboratories and ... fifty countries across the globe. ...
(Date:2/4/2016)... -- Mettler-Toledo International Inc. (NYSE: MTD ) today ... the highlights: , Sales in local currency ... year.  Reported sales decreased 3% as currency reduced sales ... earnings per diluted share as reported (EPS) were $4.44, ... EPS was $4.65, an increase of 10% over the ...
Breaking Medicine Technology: